Group items tagged

# The primary intention of creating aTags is not the categorization of the document, but the representation of the key facts inside the document. Key facts in the biomedical domain might be, for example, "Protein A interacts with protein B" or "Overexpression of protein A in tissue B is the cause of disease C". # An aTag is comprised of a set of associated entities. The size of the set is arbitrary, but will typically lie between 2 and 5 entities. For example, the fact "Protein A binds to protein B" can be represented with an aTag comprising of the three entities "Protein A", "Molecular interaction" and "Protein B". Similarly, the fact "Overexpression of protein A in tissue B is the cause of disease C" can be represented with an aTag comprising of the four entities "Overexpression", "Protein A", "Tissue B" and "Disease C". # Each document or database entry can be described with an arbitrary number of such aTags. Each aTag can be associated with the relevant portions of text or data in a fine granularity. # The entities in an aTag are not simple strings, but resources that are part of ontologies and RDF/OWL-enabled databases. For example, "Protein A" and "Protein B" are resources that are defined in the UniProt database, whereas "Molecular Interaction" is a class in the branch of biological processes of the Gene Ontology. They are identified with their URIs.

The Open Protein Structure Annotation Network (TOPSAN) is a wiki designed to collect, share and distribute information about protein three-dimensional structures, and to advance it towards knowledge about functions and roles of these proteins in their respective organisms. TOPSAN will serve as a portal for the scientific community to learn about protein structures and also to contribute their expertise in annotating protein function.

Human Proteinpedia is a community portal for sharing and integration of human protein data. It allows research laboratories to contribute and maintain protein annotations. Human Protein Reference Database (HPRD) integrates data, that is deposited in Human Proteinpedia along with the existing literature curated information in the context of an individual protein. All the public data contributed to Human Proteinpedia can be queried, viewed and downloaded.

The collaborative, 3D encyclopedia of proteins and other molecules.

The Distributed Annotation System (DAS) defines a communication protocol used to exchange biological annotations. It is motivated by the idea that such annotations should not be provided by single centralized databases, but should instead be spread over multiple sites. Data distribution, performed by DAS servers, is separated from visualization, which is done by DAS clients. DAS is a client-server system in which a single client integrates information from multiple servers. It allows a single machine to gather up sequence annotation information from multiple distant web sites, collate the information, and display it to the user in a single view. Little coordination is needed among the various information providers. DAS is heavily used in the genome bioinformatics community. Over the last years we have also seen growing acceptance in the protein sequence and structure communities.

"The value of any individual piece of knowledge is about the value of any individual piece of lego," Wilbanks said in a keynote address to the Open Access and Research Conference held in Brisbane last week. "It's not that much until you put it together with other legos." He says the ability to connect knowledge brings scientific revolutions. For example Watson and Crick's breakthrough on the structure of DNA involved them reading all the scientific papers on nucleotide bonding and encoding it in the form of a physical model, says Wilbanks. But this kind of "human scale" analysis is no longer feasible in an age when automated laboratory processes generate vast amounts of information faster than the human mind can process it. "For example, we have 45,000 papers about one protein or one gene," says Wilbanks. He says a scientist might once have analysed the impact of one drug on one gene, but now pipetting robots are capable of analysing 25,000 genes at a time. "Most of the research says the smartest of us can handle five or six independent variables at once - not 25,000," he says

The RCSB PDB provides a variety of tools and resources for studying the structures of biological macromolecules and their relationships to sequence, function, and disease.

A Resource for Comparative Grass Genomics

Here are the peer reviewed results from Folding@home