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Epigallocatechin-3-gallate ameliorates experimental autoimmune encephalomyelitis by alt... - 0 views

www.researchgate.net/...lance_among_CD4_T-cell_subsets EGCG epigallocatechin-3-gallate autoimmune disease MS cytokine cytokines inflammation
shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    EGCG found to reduce cytokine production in animal model of MS, experimental autoimmune encephalomyelitis.  Specifically, EGCG reduced interferon gamma, IL017, IL-6, IL-1beta, TNF-alpha and decreased Th1 and Th17 cells with an increase in Treg cells.
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http://www.expert-reviews.com/doi/pdf/10.1586/eci.11.67 - 0 views

www.expert-reviews.com/...eci.11.67 EGCG autoimmune disease inflammation
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  • Nathan Goodyear on 22 Jan 14
     
    Review finds EGCG benefits autoimmune disease.  Evidence primarily is animal due to human studies lacking.  EGCG is a suppresses T-cell production and inhibits NF-kappa B and thus inflammation.
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Journal of Investigative Dermatology - Abstract of article: Green Tea Polyphenol Epigal... - 0 views

www.nature.com/...jid2008103a.html EGCG keloid green tea epigallocatechin-3-gallate
shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    EGCG suppressed collagen production in keloid formation in this study.
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http://www.anaturalhealingcenter.com/documents/Thorne/articles/scleroderma11-3.pdf - 0 views

www.anaturalhealingcenter.com/...scleroderma11-3.pdf scleroderma vitamin E vitamin E natural therapy treatment autoimmune disease
shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    Review of the science that support natural therapies in scleroderma.
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http://www.clinexprheumatol.org/article.asp?a=496 - 0 views

www.clinexprheumatol.org/article.asp scleroderma vitamin E vitamin E autoimmune disease
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  • Nathan Goodyear on 22 Jan 14
     
    pilot study finds that topical vitamin E benefits healing of digital ulcers, reduced healing time and pain.
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Progressive systemic sclerosis and S-adenosylmethionine. - ResearchGate - 0 views

www.researchgate.net/...rosis_and_S-adenosylmethionine scleroderma SAMe S-adenosyl-L-methionine autoimmune disease
shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    This study used IV SAMe at 600 mg daily for 2 months and then followed up with 400 mg TID and found significant improvement in skin findings.
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http://ajcn.nutrition.org/content/76/5/1151S.full.pdf - 0 views

ajcn.nutrition.org/...1151S.full.pdf SAMe S-adenosyl-L-methionine
shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    Great review article on SAMe.
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Evening primrose oil (Efamol) in the treatmen... [Thromb Haemost. 1985] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...4082084 evening primrose oil Raynaud's GLA Gamma-linolenic acid
shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    patients given 6 grams of Evening primrose oil had improvement in Raynaud's symptoms in 8 weeks.
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Systemic sclerosis: environmental factors. [J Rheumatol. 2009] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...19797508 scleroderma environmental toxin toxins autoimmune disease
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  • Nathan Goodyear on 22 Jan 14
     
    Environmental toxins such as slice and organic solvents have been associated with the development of scleroderma.  Other exposures include bacterial, viral, pesticides, prescription drugs...
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Epidemiology of Systemic Sclerosis - 0 views

www.medscape.com/...758480 scleroderma silica environmental toxins toxin autoimmune disease
shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    silica exposure plays a role in the development of scleroderma
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T cells in systemic sclerosis: a reappraisal. - ResearchGate - 0 views

www.researchgate.net/...stemic_sclerosis_a_reappraisal scleroderma IL-6 autoimmune disease cytokines
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  • Nathan Goodyear on 22 Jan 14
     
    Article looks at the role of IL-6 in fibrosis in scleroderma.  The fibrosis in scleroderma appears to be a Th2 driven process.
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http://rheumatology.oxfordjournals.org/content/49/11/2024.full.pdf - 0 views

rheumatology.oxfordjournals.org/...2024.full.pdf EGCG epigallocatechin-3-gallate green tea NF-kappaB inflammation scleroderma autoimmune disease
shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    EGCG found to reduce extra cellular matrix production, fibrosis, and NF-kappaB activity in those with scleroderma.
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Modulation of Fibrosis in Systemic Sclerosis by Nitric Oxide and Antioxidants - 0 views

www.hindawi.com/...521958 scleroderma EGCG epigallocatechin-3-gallate green tea autoimmune disease oxidative stress sclerosis inflammation antioxidants
shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    Animal and human study finds protection against fibrosis with EGCG in those with scleroderma.
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Serum 25OH vitamin D concentrations are linked with various clinical aspects in patient... - 0 views

www.researchgate.net/...y_and_review_of_the_literature vitamin d vitamin D scleroderma autoimmune disease
shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    Vitamin D levels inversely associated with fibrosis in scleroderma.
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20S-hydroxyvitamin D3, noncalcemic product of CYP11A1 action on vitamin D3, exhibits po... - 0 views

europepmc.org/...23295467 scleroderma vitamin D vitamin d inflammation autoimmune disease
shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    vitamin D decreased fibrogenesis in invivo mouse model of scleroderma.
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Egr-ly awaiting a "personalized medicine" approach to treat scleroderma - 0 views

www.ncbi.nlm.nih.gov/...PMC3368023 morphea
shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    morphea
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Morphea subtypes are distinct autoimmune syndromes: A review of 245 adult and pediatric... - 0 views

www.ncbi.nlm.nih.gov/...PMC2938024 morphea autoimmune disease
shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    morphea 
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Updates on Morphea: Role of Vascular Injury and Advances in Treatment - 0 views

www.ncbi.nlm.nih.gov/...PMC3844232 morphea autoimmune disease
shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    morphea
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Interleukin-17A and interleukin-23 in morphea - 0 views

www.ncbi.nlm.nih.gov/...PMC3542501 morphea cytokines inflammation scleroderma autoimmune disease
shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    More discussion of morphea and the cytokine presentation.
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Cytokine profiles in localized scleroderma and relationship to clinical features - 0 views

www.ncbi.nlm.nih.gov/...PMC3632442 morphea autoimmune disease children scleroderma inflammation
shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Evaluation of the literature reveals a Th2 predominant cytokine profile in the biological specimens (sera, PBMCs, and tissue) of those with SSc
  • the literature available from studies in LS show that Th1, Th2, and Th17 cytokines may contribute equally to the pathogenesis of the disease
  • Classically, Th1 cells have been known to secrete IL-2, IFN-γ, and TNF-α, and are stimulated by IL-2 and IL-12
  • ...3 more annotations...
  • Th2 cells have been shown to be activated by IL-4 and produce IL-4, IL-5, IL-10 and IL-13
  • Th17 cells, a more recently identified Th cell subset that has altered the classic Th1/Th2 paradigm, produce IL-17 A/F, IL-21, and IL-22. IL-1, IL-6, IL-23, and TGF-β are now known to play important roles in the differentiation and propagation of the Th17 cell lineage
  • there is an overall notion that pro-inflammatory Th1 and Th17 associated cytokines are elevated during the early stages of scleroderma, whereas Th2 cytokines mainly correlate with disease damage and fibrosis extent
  • Nathan Goodyear on 22 Jan 14
     
    morphea
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