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An Overview of Melatonin and Breast Cancer | Natural Medicine Journal - 0 views

www.naturalmedicinejournal.com/...ew-melatonin-and-breast-cancer melatonin cancer
shared by Nathan Goodyear on 31 May 18 - No Cached
  • Overall its effect on cancer cells is oncostatic at physiological levels, or cytotoxic at higher concentrations
  • direct antioxidant, antimitotic, antiestrogenic, prodifferentiating and antimetastatic effects have been well characterized
  • hypothalamic-pituitary axis (HPA) and immune system
  • ...2 more annotations...
  • On a cellular level, melatonin acts as a selective estrogen receptor modulator (SERM) through decreased expression of estrogen receptor alpha and reduction in the ability of estrogen-estrogen receptor alpha (ERα) complex to bind to the estrogen response element (ERE) on DNA
  • Melatonin also acts as a selective estrogen enzyme modulator (SEEM), reducing the activity of aromatase in cells
  • Nathan Goodyear on 31 May 18
     
    review of melatonins activity in cancer battle.
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Sleep duration, melatonin and breast cancer among Chinese women in Singapore - 0 views

carcin.oxfordjournals.org/...1244 melatonin breast cancer risk sleep insomnia
shared by Nathan Goodyear on 23 Aug 11 - No Cached
  • Nathan Goodyear on 23 Aug 11
     
    sleep duration, melatonin and breast cancer risk.  Low melatonin and sleep < 6 hours increases breast cancer risk
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Effects of Melatonin and Its Analogues on Pancreatic Inflammation, Enzyme Secretion, an... - 0 views

www.ncbi.nlm.nih.gov/...PMC5454927 kyneurinic cancer acid melatonin metabolism melatonin metabolites melatonin
shared by Nathan Goodyear on 04 Aug 20 - No Cached
  • Nathan Goodyear on 04 Aug 20
     
    Melatonin metabolites involved in the cancer process. The Indoleamine dioxygenase pathway is the mechanism.
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-Absence of Melatonin and Insulin Resistance - 0 views

www.medaus.com/index.php melatonin insulin resistance
shared by Nathan Goodyear on 06 Apr 11 - No Cached
  • Nathan Goodyear on 06 Apr 11
     
    insulin resistance associated with absence of melatonin
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http://www.imedpub.com/articles/five-yearsurvival-with-highdose-melatonin-and--other-an... - 0 views

www.imedpub.com/...s-eligible-for-the-only-pa.pdf Melatonin cancer immunotherapy
shared by Nathan Goodyear on 16 Nov 18 - No Cached
  • Nathan Goodyear on 16 Nov 18
     
    High dose melatonin in the immune treatment of cancer. A must read.
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Prevention of interleukin-2-induced thrombocytopenia during the immunotherapy of cancer... - 0 views

www.ncbi.nlm.nih.gov/...7624582 cancer IL-2 melatonin platelets immunotherapy
shared by Nathan Goodyear on 01 Jun 18 - No Cached
  • Nathan Goodyear on 01 Jun 18
     
    Only abstract available here to general public.  Thrombocytopenia is associated with IL-2 therapy.  Melatonin found to block this effect when used in conjunction with IL-2 therapy.  Alone, Melatonin did not increase platelet levels.  The proposed mechanism is an inhibition of macrophage mediated destruction of plateletes.
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Amplification of eosinophilia by melatonin during the immunotherapy of cancer with inte... - 1 views

www.ncbi.nlm.nih.gov/...8346714 cancer melatonin IL-2 IL-5 eosinophils immunotherapy immune system
shared by Nathan Goodyear on 01 Jun 18 - No Cached
  • Nathan Goodyear on 01 Jun 18
     
    Melatonin concomitant with IL-2 found to increase eosinophils.  This occured with MLT and IL-2, not with IL-2 only.  The suggested mechanism is through IL-5 production from T helper cells.
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Light at Night, Chronodisruption, Melatonin Suppression, and Cancer Risk: A Review - 0 views

www.researchgate.net/...n-and-Cancer-Risk-A-Review.pdf Melatonin cancer
shared by Nathan Goodyear on 21 Feb 21 - No Cached
  • Nathan Goodyear on 21 Feb 21
     
    Great review and a must read. Melatonin with broad anti-cancer activity.
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Boosting immune system against cancer by melatonin: A mechanistic T viewpoint - 0 views

www.researchgate.net/...in-A-mechanistic-viewpoint.pdf immune system immunotherapy melatonin cancer
shared by Nathan Goodyear on 22 Feb 21 - No Cached
  • Nathan Goodyear on 22 Feb 21
     
    Another incredible read on the mechanism behind the action of melatonin. From the immune stimulating of NK, T lymphocytes...to the decrease int he Tregs and cancer associated fibroblasts in the TME.
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Melatonin Reprograms Glucose Metabolism in Cancer Cell Mitochondria - 0 views

seriesscience.com/atonin-reprograms-mitochondria Warburg effect Melatonin cancer
shared by Nathan Goodyear on 04 Aug 20 - No Cached
  • Nathan Goodyear on 04 Aug 20
     
    melatonin deficiency favors Warburg effect
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Melatonin enhances hyperthermia-induced apoptotic cell death in human leukemia cells - ... - 0 views

scholars.uthscsa.edu/...uced-apoptotic-cell-death-in-h hyperthermia melatonin apoptosis cancer leukemia
shared by Nathan Goodyear on 13 Oct 20 - No Cached
  • Nathan Goodyear on 13 Oct 20
     
    Melatonin and hyperthermia synergistic in stimulation of apoptosis.
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Melatonin inhibits both ER alpha activation and... [J Pineal Res. 2006] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...16635015 Cadmium CD estrogen receptor alpha estrogen receptor estrogen receptor melatonin hormones ER alpha
shared by Nathan Goodyear on 19 Jan 13 - No Cached
  • Nathan Goodyear on 19 Jan 13
     
    Several interesting points about this article.  Cadmium is a non-carcinogen.  Cadmium acts through estrogen receptors.  Cd acts as an estrogen.  Second, melatonin inhibits ER alpha, which promotes inflammation and growth signaling.
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An Overview of Melatonin and Breast Cancer - Natural Medicine Journal: The Official Jou... - 0 views

www.naturalmedicinejournal.com/article_content.asp cancer melatonin hormone hormones
shared by Nathan Goodyear on 19 Jan 13 - No Cached
  • Nathan Goodyear on 19 Jan 13
     
    Great review on the anti-cancer properties of melatonin.  Well referenced.
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JAMA Network | JAMA | Melatonin Secretion and the Incidence of Type 2 DiabetesMelatonin... - 0 views

jama.jamanetwork.com/article.aspx melatonin diabetes type II diabetes DM
shared by Nathan Goodyear on 09 Apr 13 - No Cached
  • Nathan Goodyear on 09 Apr 13
     
    lower melatonin secretion linked to increased diabetes risk
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Melatonin and the Immune System in Aging - 0 views

content.karger.com/...produkte.asp melatonin EPCs endothelial progenitor cells hormone hormones aging
shared by Nathan Goodyear on 11 Jul 12 - No Cached
  • Nathan Goodyear on 11 Jul 12
     
    melatonin stimulates increased production of EPCs
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Effect of melatonin on normal and... [Clin Exp Rheumatol. 1996 Sep-Oct] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...8913650 melatonin fibrosis scleroderma autoimmune disease
shared by Nathan Goodyear on 22 Jan 14 - No Cached
  • Nathan Goodyear on 22 Jan 14
     
    Melatonin inhibits fibrosis.
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[Melatonin and metabolic syndrome: is there an asso... [Ter Arkh. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...23227512 metabolic syndrome melatonin
shared by Nathan Goodyear on 01 Sep 13 - No Cached
  • Nathan Goodyear on 01 Sep 13
     
    Association between melatonin and metabolic syndrome
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PLOS ONE: Effect of Melatonin on Tumor Growth and Angiogenesis in Xenograft Model of Br... - 0 views

www.plosone.org/...10.1371%2Fjournal.pone.0085311 breast cancer melatonin hormone hormones
shared by Nathan Goodyear on 31 Jan 14 - No Cached
  • Nathan Goodyear on 31 Jan 14
     
    In vivo study finds melatonin reduced tumor growth, proliferation, and inhibited angiogenesis in breast cancer model.
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Beneficial effects of melatonin on obesity and lipid profile in young Zucker diabetic f... - 0 views

onlinelibrary.wiley.com/...abstract obesity weight loss melatonin LDL HDL
shared by Nathan Goodyear on 27 May 11 - No Cached
  • Nathan Goodyear on 27 May 11
     
    melatonin appears to help in weight loss and improve LDL and HDL cholesterol levels
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Beneficial effects of melatonin on obesity and lip... [J Pineal Res. 2011] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...21087312 obesity melatonin weight loss
shared by Nathan Goodyear on 05 May 11 - No Cached
  • Nathan Goodyear on 05 May 11
     
    Melatonin beneficial for weight loss in diabetic rat model 
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