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Nathan Goodyear

Inhibition of breast cancer cell migration by activation of cAMP signaling - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/26022351

phosphodiesterase inhibitors breast cancer phosphodiesterase 5 inhibitors cyclic AMP PDE5 inhibitors cAMP

shared by Nathan Goodyear on 08 Mar 21 - No Cached
  • Nathan Goodyear on 08 Mar 21
     
    Increase in cAMP found to inhibit breast cancer motility and migration. Here, they used cAMP analogs, forskolin and PDE inhibitors.
arunaraayala

Nigeria Air Strike on Refugee Camp Kills 52 - 0 views

www.localitynews.com/trike-on-refugee-camp-kills-52

ICRC MSF NIGERIA AIR STRIKE RANN UNICEF world news

shared by arunaraayala on 18 Jan 17 - No Cached
  • arunaraayala on 18 Jan 17
     
    Nigerian air force killed at least 52 people and injured 120 people in an air strike on a refugee camp in the northeast of the country Tuesday.
Nathan Goodyear

The Role of Cyclic Nucleotide Signaling Pathways in Cancer: Targets for Prevention and Treatment - 0 views

www.ncbi.nlm.nih.gov/...PMC3980602

Cancer cAMP cGMP

shared by Nathan Goodyear on 28 Oct 18 - No Cached
  • Nathan Goodyear on 28 Oct 18
     
    Great article on the cAMP:cGMP implication in cancer; particularly a low cAMP and increased cGMP
Nathan Goodyear

Phosphodiesterase 4D Inhibitors Limit Prostate Cancer Growth Potential - 0 views

www.ncbi.nlm.nih.gov/...PMC4312503

cyclic AMP prostate cancer cAMP phosphodiesterase inhibitors

shared by Nathan Goodyear on 08 Mar 21 - No Cached
  • Nathan Goodyear on 08 Mar 21
     
    PDE inhibitors increase cAMP and useful to inhibit invasion and mobility of prostate cancer.
Nathan Goodyear

Effect of hyperthermia on epididymal cyclic AMP levels in diabetic non-diabetic and hypophysectomized rats - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/196989

hyperthermia cAMP cyclic AMP

shared by Nathan Goodyear on 14 Feb 21 - No Cached
  • Nathan Goodyear on 14 Feb 21
     
    Hyperthermia increases cAMP
Nathan Goodyear

Effect of hyperthemia in combination with vitamin E and cyclic amp on neuroblastoma cells in culture - ScienceDirect - 0 views

www.sciencedirect.com/...0024320584903746

cAMP cancer vitamin E hyperthermia

shared by Nathan Goodyear on 14 Feb 21 - No Cached
  • Nathan Goodyear on 14 Feb 21
     
    Study finds that the additions of vitamin E and cAMP increases the efficacy of hyperthermia.
Nathan Goodyear

Cyclic AMP regulates the migration and invasion potential of human pancreatic cancer cells - 0 views

www.ncbi.nlm.nih.gov/...PMC4087083

cyclic AMP cAMP cancer

shared by Nathan Goodyear on 14 Feb 21 - No Cached
  • Nathan Goodyear on 14 Feb 21
     
    An increase in cAMP inhibits pancreatic cell invasions and migration in cell study.
Nathan Goodyear

Heat treatment induces an increase in intracellular cyclic AMP content in human epidermoid A-431 cells. - 0 views

www.ncbi.nlm.nih.gov/...PMC1151059

cAMP hyperthermia

shared by Nathan Goodyear on 14 Feb 21 - No Cached
  • Nathan Goodyear on 14 Feb 21
     
    Hyperthermia increases cAMP.
Nathan Goodyear

Cells | Free Full-Text | Targeting Cyclic AMP Signalling in Hepatocellular Carcinoma | HTML - 0 views

www.mdpi.com/...htm

cancer cyclic AMP cAMP

shared by Nathan Goodyear on 14 Feb 21 - No Cached
  • Nathan Goodyear on 14 Feb 21
     
    Telling quote from this article, "...confirm that cAMP suppression may be a critical mediator of tumorigenic mechanisms."
Nathan Goodyear

Phosphodiesterase-5 inhibitors use and risk for mortality and metastases among male patients with colorectal cancer - 0 views

www.ncbi.nlm.nih.gov/...PMC7314744

phosphodiesterase inhibitors PDE5 cAMP cancer

shared by Nathan Goodyear on 15 Feb 21 - No Cached
  • Nathan Goodyear on 15 Feb 21
     
    PDE5 shown to prevent metastasis in cancer. The mechanism is through an increase in cAMP levels.
Nathan Goodyear

Targeting cancer with phosphodiesterase inhibitors: Expert Opinion on Investigational Drugs: Vol 19, No 1 - 1 views

www.tandfonline.com/...13543780903485642

phosphodiesterase inhibitors PDE5 inhibitors cAMP PDE PDE5 cancer

shared by Nathan Goodyear on 15 Feb 21 - No Cached
  • Nathan Goodyear on 15 Feb 21
     
    Only abstract available here, but PDE inhibition, particularly PDE5 is associated with increase in cAMP in the TME.
Nathan Goodyear

Testosterone and metabolic syndrome: The link - 0 views

www.ncbi.nlm.nih.gov/...PMC3354945

low T testosterone MetS metabolic syndrome men male

shared by Nathan Goodyear on 05 Nov 12 - No Cached
  • Nathan Goodyear on 05 Nov 12
     
    good discussion on whether low T is the cause of MetS or is the result of MetS.  I am of the camp that believes that low T is required for MetS to develop in men.
Nathan Goodyear

ERα/E2 signaling suppresses the expressi... [Mol Cell Endocrinol. 2012] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...22683664

ER alpha ER-alpha Estradiol Nur77 low T Testosterone

shared by Nathan Goodyear on 15 Feb 14 - No Cached
  • Nathan Goodyear on 15 Feb 14
     
    Another support point for Estrogen as a cause of low Testosterone.  This animal study points to signaling of Estradiol through ER alpha.  This study found high expression of ER alpha and subsequent signaling by E2 decreased cAMP and Nur77 transcription factor.  Nur77 increases steroid synthesis.  This was confirmed with ER alpha knockout mice.
healthwiseindian

Health Protection Guide Camp - 0 views

www.healthwiseindian.com/...n-health-protection-guide-camp

Health Workshop HealthCamp FreeHealthCamp HealthyIndore

shared by healthwiseindian on 08 Nov 17 - No Cached
  • healthwiseindian on 08 Nov 17
     
    Free Registration The Health Workshop will focus on Diabetes, Obesity, Cancer and other health issues that affect our lifestyle. The Health Checkup shall be taken up by Dr. Binita Priyambada
Nathan Goodyear

Inhibitors of phosphodiesterase as cancer therapeutics - ScienceDirect - 0 views

www.sciencedirect.com/...S0223523418302897

invasion cancer metastasis angiogenesis phosphodiesterase inhibitors PDE inhibitors PDE5 inhibitors

shared by Nathan Goodyear on 08 Mar 21 - No Cached
  • Nathan Goodyear on 08 Mar 21
     
    PDE inhibit various stages of oncogenic transformation, growth, and metastasis through increase in cAMP.
Nathan Goodyear

Chemoresistant KM12C Colon Cancer Cells Are Addicted to Low Cyclic AMP Levels in a Phosphodiesterase 4-Regulated Compartment via Effects on Phosphoinositide 3-Kinase | Cancer Research - 0 views

cancerres.aacrjournals.org/...5248

phosphodiesterase colorectal cancer chemoresistance PDE phosphodiesterase inhibitors

shared by Nathan Goodyear on 16 Feb 21 - No Cached
  • Nathan Goodyear on 16 Feb 21
     
    PDE inhibition increases cAMP to restore chemosensitivity in this cell study.
Nathan Goodyear

Phosphodiesterase, cAMP, and cGMP - 0 views

ars.els-cdn.com/...-S0024320519303996-ga1_lrg.jpg

angiogenesis PDE phosphodiesterase cancer proliferation cGMP apoptosis cAMP cyclic AMP

shared by Nathan Goodyear on 16 Feb 21 - No Cached
  • Nathan Goodyear on 16 Feb 21
     
    Not a study, but just a nice descriptive slide.
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