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in title, tags, annotations or urlNutritional Modulation of Insulin Resistance - 0 views
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Five branched chain and aromatic amino acids (isoleucine, leucine, valine, tyrosine, and phenylalanine) showed significant associations with future diabetes
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there is increasing evidence that longer term high-protein intake may have detrimental effects on insulin resistance [68, 117–123], diabetes risk [69], and the risk of developing cardiovascular disease
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high-protein and the high GI diets significantly increased markers of low-grade inflammation
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Branched-Chain Amino Acid Supplementation in Patients with Liver Diseases - 0 views
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the optimum amount of BCAA supplements for liver disease has not been determined,
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BCAAs not only provide substrates for protein synthesis but also accelerate the biochemical machinery, which facilitates liver regeneration, compensating for progressive liver-cell death
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rapamycin signaling in the liver, a well-demonstrated effect of BCAAs, promotes albumin synthesis in the liver
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Branched Chain Amino Acid Supplementation for Patients with Cirrhosis | Clinical Correlations - 0 views
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low level of BCAAs in patients with cirrhosis is hypothesized to be one of multiple factors responsible for development of hepatic encephalopathy
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supplementation of BCAAs is thought to facilitate ammonia detoxification by supporting synthesis of glutamine, one of the non-branched chain amino acids, in skeletal muscle and in the brain as well as diminishing the influx of AAAs across the blood-brain barrier
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oral BCAA supplementation is more useful in chronic encephalopathic patients than is parenteral BCAA supplementation in patients with acute encephalopathy
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Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells - 0 views
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Accumulating evidence suggests that niclosamide targets multiple signaling pathways such as nuclear factor-kappaB (NF-kB), Wnt/β-catenin, and Notch, most of which are closely involved with cancer stem cell proliferation
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The transcription factor NF-κB has been demonstrated to promote cancer growth, angiogenesis, escape from apoptosis, and tumorigenesis
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NF-κB is sequestered in the cytosol of resting cells through binding the inhibitory subunit IκBα
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Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation - 0 views
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More than half of cancer patients are treated with IR at some point during their treatment
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fractionation schedule is the delivery of 1.8–2.0 Gy per day, five days per week
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Nuclear DNA is the primary target of IR; it causes DNA damage (genotoxic stress) by direct DNA ionization
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(PDF) mTOR inhibition improves immune function in the elderly - 0 views
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