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BNP and NT-proBNP associated with HF and worsening HF.  Also, in the same setting, elevated BNP and NT-proBNP is found to be associated with increased cardiovascular events and mortality.

4 year study finds that 200 mg CoQ10 and 200 mg Se reduced NT-proBNP and cardiovascular mortality.  

NT-proBNP found to increase with age and is found to be associated with decreasing left ventricular contractile function.