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A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice: Cell Metabolism - 0 views

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    study of mice finds that high fat diet changes genetic expression, epigenetics, to increase lifespan of mice by 13%.
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Effects of short-term high-fat overfeeding on genome-wide DNA methylation in the skelet... - 0 views

  • short-term HFO introduces DNA methylation changes on a genome-wide scale in human skeletal muscle
  • These changes were only partly reversed after 6–8 weeks
  • The induction of DNA methylation changes after 5 days of HFO supports the growing awareness of DNA methylation as a dynamic signal that is possibly relevant to short-term day-to-day metabolic adaptations, including acute exercise
  • ...4 more annotations...
  • Diverging DNA methylation levels between elderly, but not young, genetically identical twins indicate that environmental exposures throughout life may permanently influence DNA methylation, suggesting some preservation of de novo DNA methylation in adults
  • our finding of a slow reversibility rate indicates the demethylation process may be somewhat impeded compared with the induction of methylation changes by diet, which could have implications for the preservation or build-up of CpG methylation over time
  • A slow reversibility of DNA methylation induced by carcinogenic agents has likewise been observed due to ingestion of high-fat diets in rodents
  • the relationship between DNA methylation and gene expression is not always straightforward
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    Study finds variability of methylation and some genetic expression alteration with high fat diet.  Restated, what you eat interacts with your DNA to alter genetic expression.  This has implications on initiation of therapy as well as response to therapy.
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