The vast majority (88%) did not screen cardiac patients for TDS.
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shared by Nathan Goodyear on 03 Mar 14
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Testosterone deficiency syndrome and cardiovascular health: An assessment of beliefs, k... - 0 views
www.ncbi.nlm.nih.gov/...PMC3929476
low T Testosterone cardiovascular disease physicians men male hormone hormones
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Testosterone deficiency has a prevalence of 7% in the general population, rising to 20% in elderly males
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Males with CAD have lower testosterone levels than those with normal coronary angiograms of the same age,5 suggesting that the prevalence of testosterone deficiency is much higher in the CAD population
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Men with hypertension, another established risk factor for CAD, have lower testosterone compared to normotensive men
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Recent meta-analyses showed that testosterone levels are generally lower among patients with metabolic syndrome, regardless of the various definitions of metabolic syndrome that are used
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Testosterone (total and bioavailable) and sex-hormone binding globulin (SHBG) are inversely associated with the prevalence of metabolic syndrome in men between the ages of 40 and 80, and this association persists across racial and ethnic backgrounds
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Low testosterone levels have been related to increased insulin resistance and cardiovascular mortality,12 even in the absence of overt type 2 diabetes mellitus.
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testosterone levels (total and bioavailable) in middle-aged men are inversely correlated with insulin resistance
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The Massachusetts Male Aging Study (MMAS) demonstrated that low levels of testosterone and SHBG are independent risk factors for the development of type 2 diabetes,
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There is an inverse linear correlation between body mass index (BMI) and wait-to-hip ratio with testosterone and insulin-like growth factor-1 levels.
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Testosterone supplementation for 1 year in hypogonadal men has been shown to cause a significant improvement in body weight, BMI, waist size, lipid profile, and C-reactive protein levels
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TRT for 3 months in hypogonadal men with type 2 diabetes significantly improved fasting insulin sensitivity, fasting blood glucose and glycated hemoglobin.
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Testosterone replacement can improve angina symptoms and delay the onset of cardiac ischemia, likely through a coronary vasodilator mechanism
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ADT is associated with an increased risk of cardiovascular events, including myocardial infarction and cardiovascular mortality.
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ADT significantly increases fat mass, decreases lean body mass,29,30 increases fasting plasma insulin and decreases insulin sensitivity31 and increases serum cholesterol and triglyceride levels
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Startling study on the knowledge of Testosterone and cardiovascular disease in general practitioners and cardiologists in Canada. Eight-eight percent did not screen patients with cardiovascular disease for low Testosterone. A whopping 67% of physicians did not know that low T was a risk factor for cardiovascular disease, yet 62% believed Testosterone would increase exercise tolerance. The lack of knowledge displayed by physicians today is staggering and is an indictment of the governing bodies. This was a survey conducted in Canada so there are obvious limitations to the strength/conclusion of this study.
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shared by Nathan Goodyear on 13 May 14
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Testosterone deficiency is associated with ... [Eur J Endocrinol. 2013] - PubMed - NCBI - 0 views
www.ncbi.nlm.nih.gov/...23999642
low Testosterone T therapy TRT hypogonadism mortality type II diabetes diabetes men male hormone hormones
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So many studies point to Testosterone is just an association with CVD and CAD. This study finds that Testosterone therapy in those with low T and type II diabetes have a reduction in mortality 8.4% versus 19.2% in those untreated. This study also found an increase in mortality in those with low Testosterone versus those with normal Testosterone. This was a 6 year f/u of 581 men.
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Testosterone Replacement in Hypogonadal Men With Type 2 Diabetes and/or Metabolic Syndr... - 0 views
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CONCLUSIONS Over a 6-month period, transdermal TRT was associated with beneficial effects on insulin resistance, total and LDL-cholesterol, Lpa, and sexual health in hypogonadal men with type 2 diabetes and/or MetS.
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shared by Nathan Goodyear on 02 Mar 15
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Testosterone and metabolic syndrome Cunningham GR - Asian J Androl - 0 views
www.ajandrology.com/article.asp
Testosterone metabolic syndrome MetS TT total Testosterone SHBG men male hormone hormones Estradiol insulin resistance
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The relationship of low testosterone to MetS often is considered to be bidirectional; however, the relationships probably are not direct
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Many of the components of the MetS are recognized risk factors for the development of cardiovascular disease (CVD)
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Multiple cross-sectional studies have found low TT and low sex hormone binding globulin (SHBG) levels in Caucasian and African-American men with the MetS, irrespective of age
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Estradiol levels are increased in men with the MetS, and they are positively correlated with the number of abnormal components of the MetS.
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Although it is known that estrogen will increase SHBG levels, apparently the hyperinsulinism associated with obesity has a greater effect on SHBG levels
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Inflammatory cytokines are thought to have a direct effect on the pituitary to reduce LH secretion [15] and also a direct effect on Leydig cell secretion of testosterone
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Men in the lowest quartiles of serum TT, calculated free testosterone (cFT) and SHBG at baseline had the highest odds ratios for developing the MetS or DM during the 11 years follow-up
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More recently, investigators conducting population-based studies have reported that only SHBG is associated with future development of the MetS
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Additional evidence that low TT increases the risk of MetS comes from androgen deprivation treatment of prostate cancer
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Low TT and low bioavailable testosterone (bT) were each significantly associated with elevated 20 years risk of CVD mortality in an older population in which cause-specific mortality was age, adiposity, and lifestyle-adjusted.
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combination of low bT and ATP III-defined MetS is associated with increased cardiovascular mortality in men aged 40 years and above
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in elderly men, testosterone may weakly protect against CVD. Alternatively, low TT may indicate poor general health
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Muraleedharan and Jones [27] concluded that there is convincing evidence that low T is a biomarker for disease severity and mortality.
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It is widely recognized that testosterone treatment can reduce fat mass and increase lean body mass; however, until recently most reports have not been associated with much weight loss
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Changes in body composition and weight loss are considered potential mechanisms by which testosterone treatment improves insulin sensitivity and glucose control in patients with diabetes. Effects on inflammatory cytokines [38] and changes in oxidative metabolism [39] also have been reported to improve glucose metabolism.
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Testosterone replacement therapy has been reported to improve some or all of the components of the MetS.
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shared by Nathan Goodyear on 30 Jul 17
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Association Between Testosterone Replacement Therapy and the Incidence of DVT... - 0 views
www.ncbi.nlm.nih.gov/...27179907
low Testosterone Testosterone testosterone replacement therapy TRT DVT PE
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