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in title, tags, annotations or urlHigh Progesterone Receptor Expression in Prostate Cancer Is Associated with Clinical Failure - 0 views
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Currently, there is a general agreement of PGR presence in the stromal cells of PCa
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expressed in both stromal and tumor cells of the PCa tissue
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In univariate analysis, a high density level of PGR in both TE and TS was associated with CF
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STudy finds that increased Progesterone receptor expression on epithelial and stromal cells is associated with increased clinical failure of therapy. Several proposed mechanisms: 88% homologous with androgen receptor suggesting cross-stimulation and via progesterone induced increased androgen receptor gene stimulation i.e. epigenetics.
Broad targeting of angiogenesis for cancer prevention and therapy - 0 views
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vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2), interleukin-8 (IL-8), placental growth factor (PlGF), transforming growth factor-beta (TGFbeta), platelet derived growth factor (PDGF), angiopoietins (Angs) and others (reviewed in [4])
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The switch may also involve down-regulation of endogenous inhibitors of angiogenesis such as endostatin, angiostatin or thrombospondin (reviewed in [5]) and has thus been regarded as the result of tipping the net balance between positive and negative regulators
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There is a complex interrelationship between tumor hypoxia and tumor angiogenesis
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