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Nathan Goodyear

Occupational Lead Poisoning - February 15, 1998 - American Family Physician - 0 views

www.aafp.org/...stauding.html

occupational poisoning lead

shared by Nathan Goodyear on 05 Jul 11 - No Cached
  • The freely diffusible plasma fraction is distributed extensively throughout tissues, reaching highest concentrations in bone, teeth, liver, lungs, kidneys, brain and spleen
  • Inorganic lead does not undergo any metabolic transformation or digestion in the intestines, or detoxification in the liver.5
  • With chronic exposure over a long period of time, most absorbed lead ends up in bone
  • ...4 more annotations...
  • The total bodily content of lead is called the body burden; in a steady state, about 90 percent of the body burden is bound to bone.2
  • n general, lead is excreted quite slowly from the body (with the biologic half-life estimated at 10 years). Since excretion is slow, accumulation in the body occurs easily.2
  • hronic toxicity is an insidious illness with protean manifestations.3,6 Symptoms may include arthralgias, headache, weakness, depression, loss of libido, impotence and vague gastrointestinal difficulties.
  • Late effects may include chronic renal failure, hypertension, gout and chronic encephalopathy.6
  • Nathan Goodyear on 05 Jul 11
     
    occupational lead poisoning
Nathan Goodyear

The Role of Post-Exercise Nutrient Administration on Muscle Protein Synthesis and Glycogen Synthesis - 0 views

www.ncbi.nlm.nih.gov/...PMC3761704

exercise athlete athletes recovery exercise recovery training protein carbohydrates glycogen muscle

shared by Nathan Goodyear on 10 Feb 16 - No Cached
  • Whey protein was superior to that of casein in upregulating protein synthesis
  • ability to digest more rapidly than casein protein
  • Free form amino acid ingestion acts similarly to whey by displaying a rapid and strong increase in aminoacidemia
  • ...11 more annotations...
  • it appears that protein synthesis rapidly increases for up to two hours after amino acid administration
  • The intervention of dietary protein or amino acid supplementation in conjunction with resistance training has proven to effectively increase protein synthesis rates
  • 291% increase in protein synthesis following the exercise bout, while protein degradation remained unchanged from baseline quantities
  • it has been established that post-exercise EAA supplementation stimulates protein synthesis, in conjunction with a positive protein balance, comparable to that of intravenous infusion of amino acids
  • Casein and whey protein ingestion yielded similar values of net positive protein balance, and thus an overall increase in protein synthesis
  • A later analysis revealed that soy protein increased protein synthesis in rats similar to that of whey after a treadmill exercise protocol
  • A human trial, however, concluded that milk proteins (caseins and whey) in comparison to soy promoted greater muscle protein accretion when they were ingested after regular resistance training
  • Whey hydrolysate ingested after a resistance exercise bout acutely stimulated mixed muscle protein synthesis 31% greater than soy
  • adequate amount of protein (20 g) is ingested (Tipton et al., 2009) immediately before or after a resistance exercise bout
  • The rapid phase lasts approximately 30-60 minutes and does not require the presence of insulin
  • slow phase, which can last up to several hours if carbohydrate availability is high and insulin levels remain elevated
  • Nathan Goodyear on 10 Feb 16
     
    Good review of recovery supplement strategy.
Nathan Goodyear

Effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...18272344

serrapeptase digestive enzymes inflammation pain enzymes

shared by Nathan Goodyear on 07 Jan 16 - No Cached
  • Nathan Goodyear on 07 Jan 16
     
    reduced swelling and pain post molar extraction by the use of proteolytic enzyme serrapeptase.
Nathan Goodyear

Frontiers | Management of Glioblastoma Multiforme in a Patient Treated With Ketogenic Metabolic Therapy and Modified Standard of Care: A 24-Month Follow-Up | Nutrition - 0 views

www.frontiersin.org/...full

press-pulse therapy hyperbaric ketogenic metabolic therapy cancer ketogenic diet Glioblastoma glioblastoma multiforme HBOT nutrition

shared by Nathan Goodyear on 01 Apr 18 - No Cached
  • The SOC for GBM was modified in this patient to initiate KMT prior to surgical resection, to eliminate steroid medication, and to include HBOT as part of the therapy
  • the greatest therapeutic benefit for patients (near 1.0)
  • The observed reduction in blood glucose in our patient would reduce lactic acid fermentation in the tumor cells, while the elevation of ketone bodies would fuel normal cells thus protecting them from hypoglycemia and oxidative stress
  • ...30 more annotations...
  • Previous studies showed that GBM survival and tumor growth was correlated with blood glucose levels
  • Evidence indicates that glioma cells cannot effectively use ketone bodies for energy due to defects in the number, structure, and function of their mitochondria
  • The accuracy of the GKI as a predictor for therapeutic efficacy, however, is better when ketone bodies are measured from the blood than when measured from the urine
  • A reduction of glucose-driven lactic acid fermentation would not only increase tumor cell apoptosis, but would also reduce inflammation and edema in the tumor microenvironment thus reducing tumor cell angiogenesis and invasion
  • Besides serving as a metabolic fuel for GBM, glutamine is also an essential metabolite for normal immune cells
  • therapies that inhibit glutamine availability and utilization must be strategically employed to avoid inadvertent impairment of immune cell functions
  • we used the non-toxic green tea extract, EGCG, and chloroquine in an attempt to limit glutamine availability to the tumor cells
  • EGCG is thought to target the glutamate dehydrogenase activity that facilitates glutamine metabolism in GBM cells
  • Chloroquine, on the other hand, will inhibit lysosomal digestion thus restricting fermentable amino acids and carbohydrates from phagocytosed materials in the tumor microenvironment
  • HBOT to increase oxidative stress in the tumor cells
  • As glucose and glutamine fermentation protect tumor cells from oxidative stress, reduced availability of these metabolites under ketosis could enhance the therapeutic action of HBOT, as we recently described
  • Prior to subtotal tumor resection and standard of care (SOC), the patient conducted a 72-h water-only fast
  • Following the fast, the patient initiated a vitamin/mineral-supplemented ketogenic diet (KD) for 21 days that delivered 900 kcal/day
  • KD (increased to 1,500 kcal/day at day 22
  • the patient received metformin (1,000 mg/day), methylfolate (1,000 mg/day), chloroquine phosphate (150 mg/day), epigallocatechin gallate (400 mg/day), and hyperbaric oxygen therapy (HBOT) (60 min/session, 5 sessions/week at 2.5 ATA)
  • Biomarkers showed reduced blood glucose and elevated levels of urinary ketones with evidence of reduced metabolic activity (choline/N-acetylaspartate ratio) and normalized levels of insulin, triglycerides, and vitamin D
  • This is the first report of confirmed GBM treated with a modified SOC together with KMT and HBOT, and other targeted metabolic therapies
  • Glioblastoma multiforme (GBM) is the most common and malignant of the primary adult brain cancers
  • less than 20% of younger adults generally survive beyond 24 months
  • glucose and glutamine are the primary fuels that drive the rapid growth of most tumors including GBM
  • Glucose drives tumor growth through aerobic fermentation (Warburg effect), while glutamine drives tumor growth through glutaminolysis
  • The fermentation waste products of these molecules, i.e., lactic acid and succinic acid, respectively, acidify the tumor microenvironment thus contributing further to tumor progression
  • Glucose and glutamine metabolism is also responsible for the high antioxidant capacity of the tumor cells thus making them resistant to chemo- and radiotherapies
  • The reliance on glucose and glutamine for tumor cell malignancy comes largely from the documented defects in the number, structure, and function of mitochondria and mitochondrial-associated membranes
  • These abnormalities cause the neoplastic GBM cells to rely more heavily on substrate level phosphorylation than on oxidative phosphorylation for energy
  • dexamethasone not only increases blood glucose levels but also increases glutamine levels through its induction of glutamine synthetase activity
    • Nathan Goodyear
      Nathan Goodyear on 21 May 18
       
      use mannitol instead
  • Calorie restriction and restricted KD are anti-angiogenic, anti-inflammatory, anti-invasive, and also kill tumor cells through a proapoptotic mechanism
  • Evidence also shows that therapeutic ketosis can act synergistically with several drugs and procedures to enhance cancer management improving both progression free and overall survival
  • hyperbaric oxygen therapy (HBOT) increases oxidative stress on tumor cells especially when used alongside therapies that reduce blood glucose and raise blood ketones
  • The glutamine dehydrogenase inhibitor, epigallocatechin gallate (EGCG) is also proposed to target glutamine metabolism
  • Nathan Goodyear on 01 Apr 18
     
    Case study of Glioblastoma treated with ketogenic metabolic therapy as an adjuct to modified standard therapy.
Nathan Goodyear

The role of ferroptosis in digestive system cancer - 0 views

www.ncbi.nlm.nih.gov/...PMC6676710

cancer apoptosis artesunate ferropoptosis

shared by Nathan Goodyear on 23 Aug 19 - No Cached
  • Nathan Goodyear on 23 Aug 19
     
    Artesunate induces ferropoptosis and apoptosis.
Nathan Goodyear

Bile Acid Metabolism and Signaling - 0 views

www.ncbi.nlm.nih.gov/...PMC4422175

bile acids bile gallbladder liver digestion

shared by Nathan Goodyear on 19 Apr 17 - No Cached
  • Nathan Goodyear on 19 Apr 17
     
    good review of bile acid metabolism
Nathan Goodyear

M2 to M1; macrophage reprogramming can be done! - 0 views

acir.org/...hage-reprogramming-can-be-done

M1 macrophages M2 macrophages M1 M2

shared by Nathan Goodyear on 05 Oct 20 - No Cached
  • Nathan Goodyear on 05 Oct 20
     
    M2 to M1 polarization is possible.
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