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Nathan Goodyear

Fluctuation of Peripheral Blood T, B, and NK Cells during a Menstrual Cycle of Normal Healthy Women - 0 views

www.jimmunol.org/...756.full

NK cells menstrual cycle women pregnancy fertility progesterone estrogen

shared by Nathan Goodyear on 20 Apr 12 - No Cached
  • Nathan Goodyear on 20 Apr 12
     
    NK cells play role in a woman's menstrual cycle and her fertility.
Nathan Goodyear

The CD16-CD56bright NK Cell Subset Is Resistant to Reactive Oxygen Species Produced by Activated Granulocytes and Has Higher Antioxidative Capacity Than the CD16+CD56dim Subset - 0 views

www.jimmunol.org/...4513.long

NK cells CD56

shared by Nathan Goodyear on 01 May 12 - No Cached
  • Nathan Goodyear on 01 May 12
     
    Good discussion of CD 56 (bright) and CD 56 (dim) NK cells.
Nathan Goodyear

NK Cells Expressing a Progesterone Receptor Are Susceptible to Progesterone-Induced Apoptosis - 0 views

www.jimmunol.org/...5746.full

progesterone PR receptors NK cell reproduction infertility immunity

shared by Nathan Goodyear on 14 May 12 - No Cached
  • Nathan Goodyear on 14 May 12
     
    NK cells have progesterone receptors.  This has important immunologic and reproductive impact.
Nathan Goodyear

Effect of Maitake (Grifola frondosa) D-Fraction o... [J Med Food. 2003] - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...14977447

maitake mushrooms cancer Grifola frondosa NK natural killer cells food

shared by Nathan Goodyear on 28 Apr 14 - No Cached
  • Nathan Goodyear on 28 Apr 14
     
    Maitake mushroom slows cancer progress through stimulation of NK activity.
Nathan Goodyear

Scopus - Document details - 0 views

www.scopus.com/...display.url

cancer immune system NK cells NK natural killer cells innate

shared by Nathan Goodyear on 15 Jun 14 - No Cached
  • Nathan Goodyear on 15 Jun 14
     
    Stress decreases the innate immune response.  This is critical in the battle against cancer.  Specifically, low NK activity is found in stress individuals with cancer.
Nathan Goodyear

Enhancement of cytotoxicity of NK cells by D-Fraction, a polysaccharide from Grifola frondosa - 0 views

www.spandidos-publications.com/...497

Grifola frondosa maitake mushrooms cancer NK cells IL-12

shared by Nathan Goodyear on 21 May 14 - No Cached
  • Nathan Goodyear on 21 May 14
     
    The D-Fraction from maitake mushrooms enhanced the cytotoxicity from NK cells through IL-12 signaling.
Nathan Goodyear

NK Cells: Key to Success of DC-Based Cancer Vaccines? - 0 views

www.ncbi.nlm.nih.gov/...PMC3481891

NK cells dendritic cells cancer

shared by Nathan Goodyear on 20 Oct 18 - No Cached
  • Nathan Goodyear on 20 Oct 18
     
    NK and dendritic cells: the key to future cancer success?
Nathan Goodyear

Molecular mechanisms of mistletoe plant extract-induced apoptosis in acute lymphoblastic leukemia in vivo and in vitro - ScienceDirect - 0 views

www.sciencedirect.com/...S0304383508000475

mistletoe cancer leukemia NK NK cells

shared by Nathan Goodyear on 08 Jul 18 - No Cached
  • Nathan Goodyear on 08 Jul 18
     
    Mistletoe induces apoptosis of lymphoblastic leukemic cells in in vivo study. Other studies have pointed to the increase NK activity as the primary mechanism
Nathan Goodyear

http://apjai-journal.org/wp-content/uploads/2018/04/AP-030417-0067.pdf - 0 views

apjai-journal.org/...AP-030417-0067.pdf

mistletoe cancer NK NK cells

shared by Nathan Goodyear on 08 Jul 18 - No Cached
  • Nathan Goodyear on 08 Jul 18
     
    In vitro and in vivo study finds that mistletoe increased NK cytotoxicity by 35% compared to controls.
Nathan Goodyear

Natural killer cells: In health and disease - ScienceDirect - 0 views

www.sciencedirect.com/...S1658387614001083

NK cells NK disease health immune system

shared by Nathan Goodyear on 11 Oct 17 - No Cached
  • Nathan Goodyear on 11 Oct 17
     
    Nice review of NK cells in health and then in states of disease.
Nathan Goodyear

A stimulatory role of ozone exposure on human natural killer cells. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...24063543

Ozone NK cells NK cancer

shared by Nathan Goodyear on 02 Nov 18 - No Cached
  • Nathan Goodyear on 02 Nov 18
     
    Ozone increases NK cytotoxicity i.e. activity
Nathan Goodyear

PREOPERATIVE NEUROIMMUNOTHERAPY WITH SUBCUTANEONS LOW-DOSE INTERLEUKIN-2 AND MELATONIN IN PATIENTS WITH GASTROINTESTINAL TUMORS - ITS EFFICACY IN PREVENTING SURGERY-INDUCED LYMPHOCYTOPENIA - 0 views

www.spandidos-publications.com/...597

IL-2 melatonin NK cells NK immunotherapy cancer

shared by Nathan Goodyear on 10 May 18 - No Cached
  • Nathan Goodyear on 10 May 18
     
    Study of pre-operative IL-2 and melatonin versus control found an increase in the lymphocytes, T lymphocytes, and NK cell activity.  Again, no toxicity reported.
Nathan Goodyear

Cutting Edge: IL-12 Induces CD4+CD25− T Cell Activation in the Presence of T Regulatory Cells | The Journal of Immunology - 0 views

www.jimmunol.org/...641.full

immunotherapy TH1 IL-2 NK NK cells dendritic cells

shared by Nathan Goodyear on 10 May 18 - No Cached
  • Whereas IL-12 instigates Th1 immune responses, CD4+CD25+ regulatory T cells (Treg)3 actively restrain them
  • Following engagement of their TCR, Treg suppress the proliferation of conventional CD4+CD25− T responder cells in vitro
  • Furthermore, they inhibit the development of CD4+ T cell responses against alloantigens, tumor, microbial, and self-Ags in vivo.
  • ...1 more annotation...
  • Treg act to prevent spontaneous autoimmunity and to limit collateral damage to healthy tissues during adaptive immunity. However, these cells also have the potential to sabotage protective antimicrobial responses
  • Nathan Goodyear on 10 May 18
     
    Great T cell activiation review: Il-2 stimulates NK cells primarily release from TH1 cells and T cytotoxic lymphocytes are under the control of IL-12 released primarily from dendritic cells.  Inflammatory cytokines in the presence of Treg to stimulate CD4+CD25- T cell activation.
Nathan Goodyear

Improved leukemia-free survival after postconsolidation immunotherapy with histamine dihydrochloride and interleukin-2 in acute myeloid leukemia: results of a randomized phase 3 trial | Blood Journal - 0 views

www.bloodjournal.org/...88

AML acute myeloid leukemia leukemia IL-2 histamine

shared by Nathan Goodyear on 12 May 18 - No Cached
  • several independent lines of evidence suggest that cytotoxic effector cells such as T cells and natural killer (NK) cells participate in protecting patients with AML against relapse
  • A plethora of mechanisms have been proposed to account for the dysfunctional antileukemic lymphocytes in AML, including the production of T-cell- and NK-cell-inhibitory factors by AML blasts,48 a deficient expression of NK-cell receptors on leukemic cells,49 inhibition of antileukemic lymphocytes by mononuclear phagocytes,4 and an impaired stimulatory interaction between the CD28 antigen expressed by T cells and contact antigens on AML blasts
  • This trial met the primary endpoint and thus showed a significantly improved LFS for patients receiving HDC/IL-2 as compared with the current standard of care
  • ...2 more annotations...
  • T cells and NK cells with antileukemic activity can be recovered from most patients with AML in remission not receiving a transplant,
  • The present study evaluated an approach to immunotherapy in AML in which IL-2 is supplemented with histamine dihydrochloride (HDC) to enhance the function of cytotoxic antileukemic lymphocytes
  • Nathan Goodyear on 12 May 18
     
    IL-2 plus histamine in patients with AML complete remission improves leukemia free survival.
Nathan Goodyear

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2186695/pdf/je15561823.pdf - 0 views

www.ncbi.nlm.nih.gov/...je15561823.pdf

IL-2 cancer NK NK cells cytotoxic T cells immunotherapy

shared by Nathan Goodyear on 10 May 18 - No Cached
  • Nathan Goodyear on 10 May 18
     
    Great review of the IL-2 stimulated NK and cytotoxic activity against cancer.  
Nathan Goodyear

Induction of interferon and activation of NK cells and macrophages in mice by oral administration of Ge-132, an organic germanium compound. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...2581116

Germanium NK cells immune system interferon

shared by Nathan Goodyear on 30 May 18 - No Cached
  • Nathan Goodyear on 30 May 18
     
    Orally administered Germanium, at 300 mg/kg) found to increase NK activity and activation of macrophages via Interferon in mouse animal model.
Nathan Goodyear

Effect of germanium, poly-trans-[2-carboxyethyl] germasesquioxane on natural killer (NK) activity in dogs. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...12237519

cancer germanium NK cells

shared by Nathan Goodyear on 30 May 18 - No Cached
  • Nathan Goodyear on 30 May 18
     
    Germanium found to augment NK cell activity both normal dogs and dogs with adenocarcinoma.
Nathan Goodyear

[Augmentation of NK activity in peripheral blood lymphocytes of cancer patients by intermittent GE-132 administration]. - PubMed - NCBI - 0 views

www.ncbi.nlm.nih.gov/...6732257

NK cells cancer germanium

shared by Nathan Goodyear on 04 Jun 18 - No Cached
  • Nathan Goodyear on 04 Jun 18
     
    only abstract available here.  Germanium, via a intermittent oral dose, found to be effective therapy in the augementation of NK activity.
Nathan Goodyear

Human CD56bright NK Cells: An Update | The Journal of Immunology - 0 views

www.jimmunol.org/...2923

NK cells natural killer cells CD16_56 cancer disease immunology

shared by Nathan Goodyear on 28 Sep 18 - No Cached
Amol kashikar liked it
  • Nathan Goodyear on 28 Sep 18
     
    Awesome review on CD16/56 NK cells in disease, particularly cancer.
Nathan Goodyear

Artemisinin sensitizes tumor cells to NK cell-mediated cytolysis - ScienceDirect - 0 views

www.sciencedirect.com/...S0006291X20301637

cancer artemisinin NK cells

shared by Nathan Goodyear on 22 Aug 20 - No Cached
  • Nathan Goodyear on 22 Aug 20
     
    Artemisinin increases tumor cell sensitivity to NK cell killing activity.
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