Communication between genomic and non-genomic signaling events coordinate steroid hormo... - 0 views
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steroid hormones typically interact with their cognate receptor in the cytoplasm for AR, glucocorticoid receptor (GR) and PR, but may also bind receptor in the nucleus as appears to often be the case for ERα and ERβ
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This ligand binding results in a conformational change in the cytoplasmic NRs that leads to the dissociation of HSPs, translocation of the ligand-bound receptor to the nucleus
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In the nucleus, the ligand-bound receptor dimerizes and then binds to DNA at specific HREs to regulate gene transcription
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Repurposing Drugs in Oncology (ReDO)-chloroquine and hydroxychloroquine as anti-cancer ... - 0 views
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HCQ, doses for long-term use range between 200 and 400 mg per day.
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Short-term administration of CQ or HCQ rarely causes severe side effects
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Short-term administration of CQ or HCQ rarely causes severe side effects
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Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therape... - 0 views
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