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Nathan Goodyear

Does Cimetidine Improve Prospects for Cancer Patients? - 0 views

content.karger.com/...produkte.asp

cimetidine cancer therapy

shared by Nathan Goodyear on 09 Feb 11 - No Cached
  • Most studies suggest that cimetidine may improve the outcome in cancer patients by a three-pronged mechanism involving (1) inhibition of cancer cell proliferation; (2) stimulation of the lymphocyte activity by inhibition of T cell suppressor function, and (3) inhibition of histamine’s activity as a growth factor in tumours.
  • Nathan Goodyear on 09 Feb 11
     
    cimetidine as therapy for cancer?  Yes, read review
Nathan Goodyear

British Journal of Cancer - Phase I//II study of DHA-paclitaxel in combination with car... - 0 views

www.nature.com/...6602196a.html

DHA Omega-3 Taxol paclitaxel hair loss chemotherapy

shared by Nathan Goodyear on 11 Feb 11 - No Cached
  • Preclinical studies have demonstrated increased activity, relative to paclitaxel, with the potential for an improved therapeutic ratio.
  • No alopecia was seen
  • Nathan Goodyear on 11 Feb 11
     
    DHA, omega-3,  improves effectiveness of Taxol therapy; but without HAIR LOSS
Nathan Goodyear

Gonadotropin treatment restores in vitro interleukin-1β and tumour necrosis f... - 0 views

www.ncbi.nlm.nih.gov/...PMC1808705

Testosterone inflammation LPS IL-1beta TNF-alpha low T low Testosterone hypogonadism

shared by Nathan Goodyear on 14 Apr 15 - No Cached
  • Nathan Goodyear on 14 Apr 15
     
    Inverse relationship between Testosterone and LPS, IL-1beta, and TNF-alpha.
Nathan Goodyear

Why are tumour blood vessels abnormal and why is it important to know? - 0 views

www.ncbi.nlm.nih.gov/...PMC2661770

angiogenesis Cancer

shared by Nathan Goodyear on 14 Dec 18 - No Cached
  • Nathan Goodyear on 14 Dec 18
     
    Good review of the difference in the blood vessels in cancer versus healthy cells.
Nathan Goodyear

Clinical review: Specific aspects of acute renal failure in cancer patients - 0 views

www.ncbi.nlm.nih.gov/...PMC1550893

cancer renal failure

shared by Nathan Goodyear on 13 Aug 18 - No Cached
  • uric acid crystal formation in the renal tubules secondary to hyperuricaemia
  • calcium phosphate deposition related to hyperphosphataemia
  • usually develops shortly after the initiation of cytotoxic chemotherapy
  • ...18 more annotations...
  • Non-recombinant urate oxidase (Uricozyme®)
  • recombinant urate oxidase (Rasburicase®)
  • urine alkalisation may induce calcium phosphate deposition
  • renal replacement therapy should be started on an emergency basis when hydration fails to produce a prompt metabolic improvement or when ARF develops
  • Up to 50% of patients with newly diagnosed multiple myeloma have renal failure and up to 10% require dialysis
  • renal ultrasonography remains the method of choice for investigating extra-renal obstruction
  • The relief of the obstruction, either by percutaneous nephrostomy or through a ureteral stent, is the cornerstone of treatment
  • TMA may be associated with the cancer itself, with cancer chemotherapy, or with allogeneic BMT
  • thrombotic microangiopathy (TMA)
  • it may be as high as 5%
  • Most of the cases occur in patients with solid tumours, the most common type being adenocarcinoma (stomach, breast and lung)
  • The pathophysiology of the TMA-malignancy association remains controversial, although many studies suggest an insult to the vascular endothelium
  • mitomycin C. Subsequently, TMA has been reported with many anti-cancer agents, including gemcita-bine, bleomycin, cisplatin, CCNU, cytosine arabinoside, daunorubicin, deoxycoformycin, 5-FU, azathioprine and interferon α
  • Plasma exchanges have been shown to improve prognosis in the general population of patients with TMA
  • Causative factors should be looked for and antihypertensive treatment given. Lastly, in the absence of guidelines, we believe that plasma exchange should be proposed in patients with severe cancer treatment-associated TMA
  • The most widely used protective measure is saline infusion to induce solute diuresis
  • During methotrexate infusion and elimination, fluids should be given to maintain a high urinary output and urinary alkalisation should be performed to keep the urinary pH above 7.5. Rescue with folinic acid (50 mg four times a day) should be started 24 hours after each high-dose metho-trexate infusion and serum methotrexate concentrations should be measured every day
  • cyclophosphamide and ifosfamide
  • Nathan Goodyear on 13 Aug 18
     
    cancer and renal failure
Nathan Goodyear

Modulating the therapeutic response of tumours to dietary serine and glycine starvation... - 1 views

www.nature.com/...nature22056

amino acids cancer

shared by Nathan Goodyear on 15 Mar 19 - No Cached
hoangkimchi liked it
  • Nathan Goodyear on 15 Mar 19
     
    cell culture study finds that restriction of serine and glycine inhibit cancer proliferation
Nathan Goodyear

Cytotoxicity of ascorbate, lipoic acid, and other antioxidants in hollow fibre in vitro... - 0 views

www.ncbi.nlm.nih.gov/...PMC2363673

"Vitamin C" "alpha Lipoic acid" cancer ascorbic acid

shared by Nathan Goodyear on 26 Apr 19 - No Cached
  • Nathan Goodyear on 26 Apr 19
     
    Lipoic acid synergistically enhanced ascorbate cytotoxicity
Nathan Goodyear

Hyperbaric oxygen as an adjunctive therapy in treatment of malignancies, including brai... - 0 views

www.ncbi.nlm.nih.gov/...PMC4971045

HBOT hyperbaric oxygen therapy cancer radiation chemotherapy brain

shared by Nathan Goodyear on 09 Mar 18 - No Cached
  • Nathan Goodyear on 09 Mar 18
     
    great review of HBOT in cancer therapies
Nathan Goodyear

Enhancement of chemotherapy by manipulation of tumour pH | British Journal of Cancer - 0 views

www.nature.com/6690455

Cancer pH acid tumor cancer chemotherapy

shared by Nathan Goodyear on 19 Nov 18 - No Cached
  • Nathan Goodyear on 19 Nov 18
     
    Study from 1999 confirms the extracellular acid pH increases resistance to chemotherapy in in vivo study
Nathan Goodyear

Tumour-Associated Macrophages (TAMs) in Colon Cancer and How to Reeducate Them - 0 views

www.hindawi.com/...2368249

Tumor associate macrophages cancer M2 macrophages TAM M1 macrophages

shared by Nathan Goodyear on 07 Aug 19 - No Cached
  • Nathan Goodyear on 07 Aug 19
     
    Great review of TAMs and the benefit to the TME.
Nathan Goodyear

(PDF) Does the mobilization of circulating tumour cells during cancer therapy cause met... - 0 views

www.researchgate.net/...ancer_therapy_cause_metastasis

chemotherapy metastasis

shared by Nathan Goodyear on 15 Apr 20 - No Cached
  • Nathan Goodyear on 15 Apr 20
     
    Chemotherapy induced metastasis. It does happen.
Nathan Goodyear

Acidity promotes tumour progression by altering macrophage phenotype in prostate cancer... - 0 views

www.nature.com/...s41416-019-0542-2

prostate cancer tumor microenvironment TME M2 macrophages acidic pH

shared by Nathan Goodyear on 19 Apr 20 - No Cached
  • Nathan Goodyear on 19 Apr 20
     
    The acidic pH of the TME induces M2 polarization.
Nathan Goodyear

The combination of artesunate and carboplatin exerts a synergistic anti-tumour effect o... - 0 views

www.ncbi.nlm.nih.gov/...32072678

cancer chemotherapy artesunate lung cancer

shared by Nathan Goodyear on 12 Apr 20 - No Cached
  • Nathan Goodyear on 12 Apr 20
     
    Artesunate and carboplatin chemotherapy shows synergistic anti-cancer effects.
Nathan Goodyear

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer - 0 views

www.ncbi.nlm.nih.gov/...PMC2567082

cancer dichloroacetate dichloracetic acid DCA

shared by Nathan Goodyear on 07 Nov 18 - No Cached
  • The generic drug dichloroacetate is an orally available small molecule that, by inhibiting the pyruvate dehydrogenase kinase, increases the flux of pyruvate into the mitochondria, promoting glucose oxidation over glycolysis
  • The most important reason for the poor performance of cancer drugs is the remarkable heterogeneity and adaptability of cancer cells. The molecular characteristics of histologically identical cancers are often dissimilar and molecular heterogeneity frequently exists within a single tumour.
  • Because GO is far more efficient in generating ATP compared with GLY (producing 36 vs 2 ATP per glucose
  • ...9 more annotations...
  • molecule), cancer cells upregulate glucose receptors and significantly increase glucose uptake in an attempt to ‘catch up
  • early carcinogenesis often occurs in a hypoxic microenvironment, the transformed cells have to rely on anaerobic GLY for energy production.
  • Hypoxia-inducible factor (HIF) is activated in hypoxic conditions
  • evidence suggests that transformation to a glycolytic phenotype offers resistance to apoptosis
  • non-small cell lung cancer, breast cancer and glioblastoma
  • Dichloroacetate activated the pyruvate dehydrogenase, which resulted in increased delivery of pyruvate into the mitochondria
  • DCA increased GO and depolarised the mitochondria, returning the membrane potential towards the levels of the non-cancer cells, without affecting the mitochondria of non-cancerous cells
  • induction of apoptosis by DCA in non-small cell lung cancer, breast cancer and glioblastoma cell lines
  • DCA was shown to induce apoptosis in endometrial (Wong et al, 2008) and prostate (Cao et al, 2008) cancer cells
  • Nathan Goodyear on 07 Nov 18
     
    DCA as targeted therapy in cancer.
Nathan Goodyear

Intravenously administered vitamin C as cancer therapy: three cases - 0 views

www.ncbi.nlm.nih.gov/...PMC1405876

IV vitamin C vitamin C cancer

shared by Nathan Goodyear on 24 Apr 17 - No Cached
  • peak plasma concentrations obtained intravenously are estimated to reach 14 000 μmol/L, and concentrations above 2000 μmol/L may persist for several hours
  • Emerging in vitro data show that extracellular ascorbic acid selectively kills some cancer but no normal cells by generating hydrogen peroxide
  • Death is mediated exclusively by extracellular ascorbate, at pharmacologic concentrations that can be achieved only by intravenous administration
  • ...6 more annotations...
  • Vitamin C may serve as a pro-drug for hydrogen peroxide delivery to extravascular tissues, but without the presence of hydrogen peroxide in blood
  • not all cancer cells were killed by ascorbic acid in vitro
  • Intravascular hemolysis was reported after massive vitamin C administration in people with glucose-6-phosphate dehydrogenase deficiency
  • Administration of high-dose vitamin C to patients with systemic iron overload may increase iron absorption and represents a contraindication
  • Ascorbic acid is metabolized to oxalate, and 2 cases of acute oxalate nephropathy were reported in patients with pre-existing renal insufficiency given massive intravenous doses of vitamin C
  • Rare cases of acute tumour hemorrhage and necrosis were reported in patients with advanced cancer within a few days of starting high-dose intravenous vitamin C therapy, although this was not independently verified by pathologic review
  • Nathan Goodyear on 24 Apr 17
     
    IV vitamin C associated with prolonged survival in 3 patients with different cancers.  Peak serum levels reached 14,000 micromol/L, which levels above the 1,000 micro mol/L (cancer cell cytotoxic threshold) were maintained for hours
Nathan Goodyear

Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of a... - 0 views

www.sciencedirect.com/...S0891584916304087

hypoxia VEGF HIF-1alpha vitamin C HIF-1 cancer GLUT

shared by Nathan Goodyear on 01 Apr 21 - No Cached
  • Nathan Goodyear on 01 Apr 21
     
    Very nice mouse study. They reduced hypoxia signialing, HIF-1alpha, via daily vitamin C administration. Also a very interesting point, that the vitamin C had a much longer half life within the tumor than normal tissue-up to 48 hours compared to 30 minutes in normal. So, that begs the question, what does higher dose do? In this study they also saw a reduction in angiogenesis and tumor growth.
Nathan Goodyear

A vascular niche and a VEGF-Nrp1 loop regulate the initiation and stemness of skin tumo... - 0 views

www.nature.com/...nature10525

cancer stem cells VEGF angiogenesis stem

shared by Nathan Goodyear on 23 Apr 21 - No Cached
  • Nathan Goodyear on 23 Apr 21
     
    Not specifically focused on CSC, but anti-angiogenic therapies via blockade of VEGF inhibit stem ness.
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