calorie restriction, though not malnutrition, is associated with longevity as determined by increased telomerase reverse transcriptase and a reduction in aged related diseases. Granted this was a mouse model.
Estradiol inhibited EPC aging in this study. What is interesting, is that this was accomplished through telomerase activity and thus increasing telomere length.
Androgen deprivation therapy reduces Telomerase activity in androgen dependent prostate cancer cell lines. Conversely, Testosterone increases Telomerase activity. In these cell lines Telomerase activity is positively associated with prostate cancer.