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Nathan Goodyear

Glutathione restores normal cell activation and cell cycle progression in cis-platinum ... - 0 views

www.ncbi.nlm.nih.gov/...PMC1977464

cis-platinum glutathione chemotherapy

shared by Nathan Goodyear on 12 Sep 11 - No Cached
  • Nathan Goodyear on 12 Sep 11
     
    glutathione useful in cis-platinum chemotherapy
Nathan Goodyear

Platinum Sensitivity in a BRCA1 Mutation Carrier with Advanced Breast Cancer - ScienceD... - 0 views

www.sciencedirect.com/...S0936655509000314

platinum breast cancer BRCA

shared by Nathan Goodyear on 14 May 21 - No Cached
  • Nathan Goodyear on 14 May 21
     
    BRCA indicates increased platinum sensitivity and decreased doxorubicin sensitivity.
Nathan Goodyear

Anemia in cancer - 0 views

annonc.oxfordjournals.org/...vii167.long

cancer anemia

shared by Nathan Goodyear on 30 Mar 15 - No Cached
  • Anemia is a frequent finding in cancer patients, occurring in >40% of cases
  • chemotherapy, the incidence of anemia may rise to 90%
  • Anemia exerts a negative influence on the quality of life
  • ...17 more annotations...
  • Anemia has also been identified as an adverse prognostic factor
  • mild (10 g/dl—normal), moderate (8–10 g/dl), severe (6.5–8 g/dl) and life threatening (<6.5 g/dl or unstable patient) anemia
  • anemia in cancer patients is often multifactorial.
  • Cancer itself can directly cause or exacerbate anemia either by suppressing hematopoiesis through bone marrow infiltration or production of cytokines that lead to iron sequestration, or by reduced red blood cell production
  • in inflammatory anemia, iron deficiency should be defined by a low transferrin saturation of <20%, ferritin levels of <100 ng/ml and a low reticulocyte hemoglobin concentration of <32 pg
  • anemia to thrombocytosis, as commonly seen in cancer patients
  • TNF-α inhibits hemoglobin production
  • treatment itself may be a major cause of anemia
  • Other cytokines, such as interleukin-6 (IL-6), IL-1 and interferon-γ, have also been shown to inhibit erythroid precursors in vitro [9], albeit to a lesser extent
  • In inflammation, from whatever cause, IL-6 induces the liver to produce hepcidin. Hepcidin decreases iron absorption from the bowel and blocks iron utilization in the bone marrow
  • Numerous in vitro studies have illustrated the central role of TNF-α in the pathogenesis of anemia
  • nephrotoxic effects of particular cytotoxic agents such as platinum salts can also lead to the persistence of anemia through reduced Epo production by the kidney
  • Currently two options are at the disposal of the clinician for the treatment of anemia in cancer patients: transfusion of packed red blood cells and the use of erythropoiesis-stimulating agents (ESAs)
  • The goal of the treatment is to relieve the symptoms of anemia such as fatigue and dyspnea.
  • Transfusion of 1 unit of packed red blood cells has been estimated to result in an increase in the hemoglobin level of 1 g/dl in a normal-sized adult
  • a higher mortality rate in patients receiving ESA treatment
  • Recent concerns regarding the risk of thromboembolism in patients treated with ESA have been corroborated by the meta-analyses conducted by Tonnelli and Bennett
  • Nathan Goodyear on 30 Mar 15
     
    Great review of anemia in Cancer:  1)  blood loss 2)  increased RBC loss 3)   decreased RBC production Cancer infiltration of marrow can reduce hematopoiesis.  Inflammatory cytokines can reduce hematopoiesis.  Inflammatory cytokines can block Fe absorption.  Chemo and radiation can cause anemia--particularily platinum based therapies.
Nathan Goodyear

Chemotherapy for Patients with BRCA1 and BRCA2-Mutated Ovarian Cancer: Same or Differen... - 0 views

ascopubs.org/...EdBook_AM.2015.35.114

chemotherapy breast cancer BRCA platinum

shared by Nathan Goodyear on 14 May 21 - No Cached
  • Nathan Goodyear on 14 May 21
     
    BRCA and increased platinum sensitivity.
Nathan Goodyear

BRCA Mutation Frequency and Patterns of Treatment Response in BRCA Mutation-Positive Wo... - 0 views

ascopubs.org/...JCO.2011.39.8545

cancer BRCA platinum chemotherapy

shared by Nathan Goodyear on 14 May 21 - No Cached
  • Nathan Goodyear on 14 May 21
     
    New research points to increased sensitivity of breast cancer BRCA with platinums; not resistance.
Nathan Goodyear

"BRCAness" syndrome in ovarian cancer: a case-control study describing the clinical fea... - 0 views

pubmed.ncbi.nlm.nih.gov/18955455

platinum cancer chemotherapy BRCA

shared by Nathan Goodyear on 14 May 21 - No Cached
  • Nathan Goodyear on 14 May 21
     
    Improved survival with platinum chemotherapy with BRCA.
Nathan Goodyear

The Role of BRCA Status on the Prognosis of Patients with Epithelial Ovarian Cancer: A ... - 0 views

www.ncbi.nlm.nih.gov/...PMC4006804

platinums BRCA chemotherapy cancer

shared by Nathan Goodyear on 14 May 21 - No Cached
  • Nathan Goodyear on 14 May 21
     
    INcreased chemosensitivity, OS, of BRCA + with chemotherapy; particular platinums.
Nathan Goodyear

Factors of the ovarian cancer resistance to combined chemotherapy with platinum prepara... - 1 views

link.springer.com/...BF02445197

factors ovarian cancer resistance combined chemotherapy platinum glutathione

shared by Nathan Goodyear on 30 Jan 13 - No Cached
  • Nathan Goodyear on 30 Jan 13
     
    glutathione and ovarian cancer
Nathan Goodyear

A phase II study of chemoneuroimmunotherapy with platinum, subcutaneous low-dose interl... - 0 views

www.ncbi.nlm.nih.gov/...12073777

Melanoma chemotherapy IL-2 melatonin Cancer

shared by Nathan Goodyear on 16 Nov 18 - No Cached
  • Nathan Goodyear on 16 Nov 18
     
    Low dose cisplatin, low dose IL-2 and high dose melatonin as effective as first line therapy in the treatment of melanoma
Nathan Goodyear

Orthogonal self-assembly of an organoplatinum(II) metallacycle and cucurbit[8]uril that... - 0 views

www.pnas.org/8087

curcumin cancer platinum

shared by Nathan Goodyear on 07 Aug 18 - No Cached
  • Nathan Goodyear on 07 Aug 18
     
    cucurcumin complexed with palatinum to improve solubility and delivery of the curcumin to cancer cells. Only abstract available here.
Nathan Goodyear

Oncotarget | Preclinical evaluation of a nanoformulated antihelminthic, niclosamide, in... - 0 views

www.oncotarget.com/index.php

Niclosamide cancer ovarian cancer

shared by Nathan Goodyear on 16 Apr 18 - No Cached
  • Ovarian cancer is the most lethal gynecologic malignancy in the world
  • paclitaxel represents a breakthrough in the treatment of ovarian cancer, the overall 5-year survival rate of patients with stage III disease is still approximately 40%
  • Targeting cancer stem cells is an emerging concept in cancer therapy
  • ...8 more annotations...
  • Ovarian cancer stem cells play an important role in chemoresistance and cancer recurrence
  • Furthermore, recent studies indicate that niclosamide exhibits anticancer effects against various human cancer cells by acting on multiple cell signaling pathways and inducing mitochondrial uncoupling [16–21]
  • has low systemic bioavailability (~10%) when administered orally, which is beneficial for treating local parasitic infections of the intestines while minimizing systemic exposure
  • The nano-NI demonstrated significantly higher inhibitory effects on sphere formation than the original niclosamide did
  • the nano-NI formulation decreased the metabolic activity of ovarian cancer cells and caused a metabolic shift from oxidative phosphorylation to glycolysis
  • This toxicity evaluation showed that oral nano-NI had no toxic effect on either group of mice in terms of weight, plasma albumin levels, and blood cell counts, and revealed no adverse effects on vital organ function in the rodents, which suggests that nano-NI is safe for animals
  • niclosamide inhibits tumor cell growth by interrupting multiple pathways (Wnt, Notch, STAT3, NF-κB, and mTORc1) and the generation of reactive oxygen species in several cancer cells
  • The current standard therapy for ovarian cancer includes taxanes and platinum-based chemotherapy after cytoreductive surgery. Among treated patients, nearly 70 to 80% will experience disease recurrence
  • Nathan Goodyear on 16 Apr 18
     
    nano-Niclosamide more effective than traditional Niclosamide in in vitro and in vivo ovarian cancer.
Nathan Goodyear

Prolonged stabilization of platinum-refractory ovarian cance... : Medicine - 0 views

journals.lww.com/...articleviewer.aspx

ascites Intra-peritoneal mistletoe ovarian cancer cancer

shared by Nathan Goodyear on 07 Apr 21 - No Cached
  • Nathan Goodyear on 07 Apr 21
     
    Mistletoe injected intraperitoneal 3 x weekly to reduce ascites.
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