Plant-Based Nutritional Supplementation Attenuates LPS-Induced Low-Grade Systemic Activ... - 0 views
www.ncbi.nlm.nih.gov/...PMC7826722
TLR4 inflammation LPS metabolic endotoxemia plant-based nutrition plant-based diet plant-based
shared by Nathan Goodyear on 03 Sep 21
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consumption of this particular diet for at least a 2-month period helped to reduce the outcomes of both acute and chronic inflammation induced by LPS.
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chronic inflammation compromised both glucose and insulin tolerance, which is normally seen in certain chronic metabolic diseases
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diet enriched in fruits and vegetables (and consequently phytochemicals) was able to reverse the process and maintain and even elevate insulin sensitivity and glucose tolerance
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LPS-mediated effects are related to an increase in TLR4 levels that triggers the activation of nuclear factor-kB (NF-kB), a transcription factor that activates a cascade of inflammatory mediators [41]. These factors control the transcription of inflammatory mediators, such as IL-1β, IL-6, TNF-α, TNF-β, INF-α, INFβ, INF-γ
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Inflammation can alter insulin action and give rise to diabetes and obesity by blocking insulin receptor downstream events, impairing insulin receptor substrate 1 (IRS-1) activation and phosphatidylinositol 3-kinase-dependent (PI3K) pathways, therefore compromising insulin signaling
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systemic inflammation (generated by LPS) also increased neopterin levels in the urine and resulted in altered neuronal activity by decreasing dopamine (DA) metabolism
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an increase in neopterin levels has been recognized a sensitive biomarker for immune system activation
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Our experiments denoted that these diets were able to diminish inflammatory mediators and oxidative damage