mouse study finds that long-term cipro can lead to biochemical disruption of the testicles resulting in infertility, effected sperm counts, and decreased Testosterone.
New study suggests global epigenetics is the cause behind fluoroquinolone mechanism of the Tendinopathies. Specifically, they suggest that Iron chelation by the fluoroquinolones supresses the expression of P4HA1 and LH1 to lead to weakend collagen. They also described decreased epigenetic changes in collagen hydroxylation and suppression of HIF-1alpha as mechanisms contributing to the tendinopathies as well.