The most
convincing evidence for beneficial effects of omega-3 PUFA is to be
found in mood disorders. A meta-analysis of trials involving patients
with major depressive disorder and bipolar disorder provided evidence
that omega-3 PUFA supplementation reduces symptoms of depression.
Furthermore, meta-regression analysis suggests that supplementation
with eicosapentaenoic acid may be more beneficial in mood disorders
than with docosahexaenoic acid,