Skip to main content

Home/ Dr. Goodyear/ Group items tagged Pain

Rss Feed Group items tagged

Filter: All | Bookmarks | Topics Simple Middle
Nathan Goodyear

Adapted ECHO-7 virus Rigvir immunotherapy (oncolytic virotherapy) prolongs survival in ... - 0 views

www.ncbi.nlm.nih.gov/...PMC4560272

RIGVIR cancer oncolytic therapy immunotherapy cancer immunotherapy

shared by Nathan Goodyear on 16 Oct 18 - No Cached
  • Rigvir is a 2 ml frozen solution
  • ECHO-7 virus strain, Picornaviridae family, Enterovirus genus, Enteric Cytopathic Human Orphan (ECHO) type 7, group IV, positive-sense single-stranded RNA virus
  • a few side effects were reported, for example subfebrile temperature (37.5°C for a couple of days), pain in the tumour area, sleepiness and diarrhoea
  • ...12 more annotations...
  • In this retrospective study, however, there was no record of any untoward side effect from Rigvir treatment or its discontinuation
  • Early observations of tumour regressions after virus infections have been published starting from the late 19th century
  • The present results show that in substage IB, IIA, IIB and IIC melanoma patients, Rigvir administration after surgery significantly (P<0.05) prolongs survival compared with patients who were managed according to current published guidelines
  • no value higher than grade 2 was recorded in Rigvir-treated patients. This is in contrast to most other cancer therapies, where grades 3 and 4 are frequently observed
  • Administration of virus induces the formation of neutralising antibodies that might potentially influence the efficiency of Rigvir
  • In 94 healthy adult participants tested, the titres were found to be low (1 : 20 to 1 : 62) 39,40. When tested in 155 adult cancer patients who had not been treated with Rigvir, neutralising antibodies against ECHO-7 were detected in ∼50% of the patients
  • the presence of ECHO-7 antibodies was shown to increase with age in children and level off to a plateau of around 75% in adults
  • Rigvir is an immunomodulator that affects both the humoral, antibody-mediated, and the cellular immune systems
  • neutralising antibodies do not affect efficacy when local or regional administration is used
  • it reduces the viability of melanoma, as well as pulmonary, gastric, pancreatic, bone, and breast cancer cell cultures
  • It is oncolytic in melanoma and rectum cancer patients
  • shown to improve the 5-year survival in rectum cancer patients
  • Nathan Goodyear on 16 Oct 18
     
    RIGVIR shown to improve survival against standard therapy in stage IB, IIA, IIB, and IIC in malignant melanoma patients in retrospective study. Side effects are minimal. Neutralizing antibodies are an area to watch that likely effects individual outcome beyond that of the type of cancer
Nathan Goodyear

Dexamethasone prevents postoperative nausea and vomiting: Benefit versus risk - Science... - 0 views

www.sciencedirect.com/...S1875459711000609

dexamethasone nausea

shared by Nathan Goodyear on 14 Aug 18 - No Cached
  • 2.5–10 mg
  • Dexamethasone is a synthetic form of adrenocorticoid, and acts mainly as a glucocorticoid receptor with almost no mineralocorticoid receptor functions
  • dexamethasone increases synthesis of endorphin in the body,14 uplifting moods and appetite
  • ...2 more annotations...
  • serotonin Type 3 receptor antagonist (ondansetron, dolasetron, and granisetron), dopamine Type 2 receptor antagonist (droperidol and metoclopramide), muscarinic cholinergic Type 1 receptor antagonist (scopolamine), and histamine Type 1 receptor antagonist (promethazine and prochlorperazine)
  • dexamethasone can effectively prevent PONV7, 8, 9 induced by epidural morphine used to reduce postoperative pain
  • Nathan Goodyear on 14 Aug 18
     
    Dexamethasone for nausea
Nathan Goodyear

American Journal of Obstetrics & Gynecology Home Page - 0 views

www.ajog.org/...fulltext

"Vaginal mesh" immune system

shared by Nathan Goodyear on 31 Aug 18 - No Cached
  • M1 macrophages are characterized by the secretion of reactive oxygen species and proinflammatory cytokines and chemokines and can be identified via the cell surface marker CD86
  • M2 macrophages secrete growth factors and antiinflammatory immune modulators and can be identified by the cell surface marker CD206
  • an overzealous M2 response can also lead to excess tissue deposition and fibrosis
  • ...14 more annotations...
  • Studies of similar meshes that are used in hernia repair have demonstrated that all polypropylene meshes induce a prolonged inflammatory response at the site of implantation
  • the long-term presence of activated inflammatory cells, such as macrophages at the mesh tissue interface, can impact negatively the ability of the mesh to function as intended.
  • All M1 proinflammatory and M2 proremodeling cytokines and chemokines were increased in mesh explants as compared with nonmesh tissue (Table 3Table 3), which indicated a robust, active, and ongoing host response to polypropylene long after implantation
  • Comparison of the ratio of the M2 proremodeling cytokines (IL-10+IL-4) with the M1 proinflammatory cytokines (TNF-α+IL-12p70) revealed a decrease in mesh explants as compared with controls (P = .003), which indicated a shift towards a proinflammatory profile.
  • Mesh explants contained a higher number of total cells/×200 field when compared with controls (682.46 ± 142.61 cells vs 441.63 ± 126.13 cells; P < .001) and a lower ratio of M2:M1 macrophages (0.260 ± 0.161 cells vs 1.772 ± 1.919; P = .001), which supported an ongoing proinflammatory response.
  • the host response was proportional to the amount of material in contact with the host
  • A persistent foreign body response was observed in mesh-tissue complexes that were excised from women who required surgical excision of mesh months to years after mesh implantation
  • The host response was characterized by a predominance of macrophages with an increase in both proinflammatory and proremodeling cytokines/chemokines along with increased tissue degradation, as evidenced by increased MMP-2 and -9
  • Mesh-tissue complexes removed for mesh exposure had increased pro–MMP-9 that indicated a proinflammatory and tissue destruction–type response
  • The presence of macrophages, elevated cytokines, chemokines, and MMPs in tissue-mesh complexes that were excised from patients with exposure or pain suggests that polypropylene mesh elicits an ongoing host inflammatory response
  • In the presence of a permanent foreign body, the implant is surrounded with a fibrotic capsule because it cannot be degraded
  • For hernia meshes, if the fibers are too close (<1 mm), the fibrotic response to neighboring fibers overlaps, or “bridges,” and results in “bridging fibrosis” or encapsulation of the mesh
  • Gynemesh PS has a highly unstable geometry when loaded that resulted in pore collapse and increasing stiffness of the product
  • mesh shrinkage (50-70%) has been described to occur after transvaginal insertion of prolapse meshes
  • Nathan Goodyear on 31 Aug 18
     
    Mesh and the abnormal immune response.
zoran de

Buy Innoveda Arthrella Online - Nutritional Supplements for Osteoarthritis & Joint Pain - 0 views

www.charakusa.com/...arthrella

Nutritional Supplements Dietary Natural Treatments Herbal Health Supplement Treatment Arthritis For What is osteoarthritis Medicine the of Ayurvedic Medicines Organic

shared by zoran de on 06 Oct 16 - No Cached
  • zoran de on 06 Oct 16
     
    Arthrella is a rich combination of joint support phytochemicals. Arthrella combines the extracts of 4 herbs which offer support to the bones and the joints and help regulate healthy active joints and muscles. Arthrella helps in promoting normal structure and functioning of musculoskeletal system Social Media Site https://www.youtube.com/user/CharakPharma https://www.facebook.com/CharakPharma https://twitter.com/charak_pharma https://plus.google.com/+charakpharma https://www.linkedin.com/company/charak-pharma-pvt.-ltd. https://www.pinterest.com/OTCSupermarket/charak-pharma/ https://plus.google.com/u/0/communities/112690639266834894016 CONTACT US Charak Pharma (USA) inc 303-5th Avenue, Suite # 1007 New York, NY 10016 United States Email : enquiry@charakusa.com info@charakusa.com 91 22 33016734 Google My Business Location- http://listings.findthecompany.com/l/474216049/Charak-Pharma-Usa-Inc-in-New-York-NY Buy Innoveda Arthrella Online - Shop, Cart & checkout Page Url Shop - http://www.charakusa.com/shop/ Add to Card - http://www.charakusa.com/cart/ Proceed to Checkout- http://www.charakusa.com/checkout/
fnfdoc

How To Relieve Constipation Fast | Health Blog - 0 views

www.fnfdoc.com/...relieve-constipation-fast

Constipation Pain Relieve Symptoms

shared by fnfdoc on 25 May 18 - No Cached
  • fnfdoc on 25 May 18
     
    How To Relieve Constipation Fast? About twelve percent of the population worldwide report constipation each year. It is characterized by undue effort and time to expel the stool. Here we discuss some useful home remedies to treat constipation. Sometimes it can be really stubborn and won't go away.
  • fnfdoc on 25 May 18
     
    An average human being visits the toilet six times a day and stays there for about two minutes. However, attending the call of nature is not always this easy. Sometimes, a common gastrointestinal condition called constipation occurs. It becomes difficult to expel the feces. A desire to visit the washroom is not enough to physically eliminate the feces.
trungtamnamkhoa

Learn About Male Foreskin Disease - Men's Health Clinic - 1 views

menhealth.vn/...bao-quy-dau

hormone Testosterone Men Disease Male cancer health healthy

shared by trungtamnamkhoa on 25 Jun 19 - No Cached
  • trungtamnamkhoa on 25 Jun 19
     
    Long foreskin It was a situation in which he was always so shy when he opened his eyes even though he could easily go out easily, without pain, without tightening. Even when "greeting the flag" he kept hiding the ball under the glans or just poking out. Must have to wait for the hand of "big brother" to slide down to bear the road to see the world around. When you have a clear understanding of the above concepts, the men of the race race to wonder, "Why is the foreskin of my friend not narrowed but why are my and my brother's bad luck?". The doctor asked for the correct answer, partly because of his bad luck, from birth to growing up, the foreskin was like that, "keep loving and protecting the foreskin." But it is not uncommon for other reasons to make men suffer because of foreskin: First, we have to recall the untimely and improper foreskin effects of parents when children are young. It is these overly "anxious" actions of parents that have counterproductive and narrowed down the latter. There are some autoimmune diseases, making the foreskin a fibrous day, loss of elasticity, gradually worsening, called BXO (balanitisxerotica obliterans) - a narrowed glans. This can also be interpreted as a form of glans, which can even cause narrowing of the urinary tract to lead to urinary retention. Some cases of glans and foreskin have been repeatedly infected by microbiological agents (bacteria, viruses, fungi, etc.), which can be re-infected and non-stop treatment is also available. can lead to complications of fibrosis and secondary stenosis
trungtamnamkhoa

Learn More About Foreskin Disease - Men's Health Clinic In Viet Nam - 1 views

menhealth.vn/-de-muon-thuo-cua-dang-may-rau

cancer hormone Testosterone Men health healthy Foreskin Disease

shared by trungtamnamkhoa on 25 Jun 19 - No Cached
  • trungtamnamkhoa on 25 Jun 19
     
    Semi-glans It is a situation in which the boy is still "open his eyes" but is either very difficult or painful or requires the help of slipping from the homeowner. Having opened the eyes is not necessarily good in this case because soon enough the foreskin will form a tightening ring just below, obstructing the healed blood, leading to edema, and when the penis is hard, everything even worse.
Nathan Goodyear

The Risk of Fluoroquinolone-induced Tendinopathy and Tendon Rupture - 0 views

www.ncbi.nlm.nih.gov/...PMC2921747

flouroquinolones ciprofloxacin levoquin tendinitis tendinopathy Tendon rupture

shared by Nathan Goodyear on 02 Aug 17 - No Cached
  • Achilles tendinitis or rupture is among the most serious side effects associated with FQ use
  • The large body of data provided by clinical reports, histopathological examination, and experimental studies provides cogent evidence supporting a direct link between FQ use and tendonitis/tendon rupture
  • Risk factors associated with FQ-induced tendon disorders include age greater than 60 years, corticosteroid therapy, renal failure, diabetes mellitus, and a history of musculoskeletal disorders
  • ...17 more annotations...
  • The average age of FQ-induced tendinopathy is 64 years, with a male-to-female ratio of 2:1, and a 27-percent incidence of bilateral involvement
  • Although more than 95 percent of cases of tendinitis/rupture secondary to FQ involve the Achilles tendon, other reported sites of tendon involvement include the quadriceps, peroneus brevis, and rotator cuff
  • FQs demonstrate a 3.8-fold greater risk for development of Achilles tendinitis/rupture
  • a large population-based case control analysis, patients treated with FQs exhibited a substantially increased risk of developing tendon disorders overall (1.7-fold), tendon rupture (1.3-fold), and ATR (4.1-fold)
  • patients taking FQs with concurrent exposure to corticosteroids were found to experience a compounding effect on the risk of tendon rupture, specifically a 46-fold greater predisposition
  • Some authors have recommended that patients with a history of Achilles tendinitis and advanced age should not be prescribed FQ antibiotics
  • Approximately 50 percent of patients will recover within 30 days, with 25 percent of patients having symptoms persistent for longer than two months
  • The mean latency period between the start of FQ treatment and occurrence of tendinopathy has been reported to be a few hours to months, with a median onset of 6 days
  • The exact pathophysiology of FQ-induced tendinopathy remains elusive
  • it is possible that FQs have a direct cytotoxic effect on enzymes found in mammalian musculoskeletal tissue
  • It has been theorized that FQs disproportionately affect human tendons that have a limited capacity for repair, such as in older patients or structural compromise (i.e., pre-existing tendinopathy or trauma)
  • histopathological findings are similar to those observed in overuse conditions in athletes
  • Treatment with a FQ should be discontinued and physical therapy initiated
  • treatment should include rest and decreasing the physical load on the tendon.
  • Approximately 85 percent of patients present in less than one month
  • Because rupture can occur even late in the course of treatment or after discontinuation of FQ use, patients receiving a FQ should be counseled to seek medical attention immediately if symptoms, such as redness, pain, swelling, and stiffness, develop
  • FQs should be used cautiously in patients with risk factors associated with tendinitis, such as advanced age, history of tendon rupture, corticosteroid use, and/or acute or chronic renal dysfunction
  • Nathan Goodyear on 02 Aug 17
     
    Great review of the link between flouroquinolones and Tendinitis and Tendon rupture.  Yes, there is a direct link.
Nathan Goodyear

http://www.fertstert.org/article/S0015-0282(16)62744-9/pdf - 0 views

www.fertstert.org/...pdf

male fertility male reproduction contraception vasectomy

shared by Nathan Goodyear on 04 Aug 17 - No Cached
  • Nathan Goodyear on 04 Aug 17
     
    good review of male reproductive physiology.  
Nathan Goodyear

Magnesium L-threonate prevents and restores memory deficits associated with n... - 0 views

www.ncbi.nlm.nih.gov/...24077207

magnesium threonate magnesium memory brain brain health

shared by Nathan Goodyear on 26 Sep 17 - No Cached
  • Nathan Goodyear on 26 Sep 17
     
    Magnesium threonate useful in reducing TNF-alpha  and improve memory in animal model.  Magnesium threonate crosses the BBB well.
chrismance

Best Strains For Anxiety - Getmarijuananearme.com - Strains for anxiety - 0 views

getmarijuananearme.com/t-cannabis-strains-for-anxiety

cancer hormones hormone Testosterone inflammation disease Obesity anxiety depression stress pain PTSD

shared by chrismance on 01 Jun 21 - No Cached
  • chrismance on 01 Jun 21
     
    An educating article about how cannabis can help with anxiety as well as many other defects
spineneuro

Лучшие хирурги нейро и позвоночника в Индии: Исцелите свою болезненную спину ... - 0 views

top-neuro-and-spine-surgeons-in-india.blogspot.com/...st-spine-surgeon-in-delhi.html

Доктор Арвинд Джайсвал лучший хирург позвоночника в Дели Д-р Арвинд Джайсвал Лучший хирург позвоночника в Индии

shared by spineneuro on 14 Aug 21 - No Cached
  • spineneuro on 14 Aug 21
     
    Доктор Арвинд Джайсвал, лучший хирург позвоночника в Дели, стремится предоставить пациентам лучшие, проверенные методы лечения их неврологических состояний.
spineneuro

الخبرات الطبية العربية الحقيقية في الهند: ابدأ رحلة جديدة من حياة خالية من ال... - 0 views

arabrealmedicalexperiences.blogspot.com/...inal-fusion-surgery-india.html

تكلفة جراحة دمج العمود الفقري جراحة دمج الفقرات الالتحام الشوكي

shared by spineneuro on 28 Apr 22 - No Cached
  • spineneuro on 28 Apr 22
     
    تكلفة جراحة دمج العمود الفقري هذه ميسورة التكلفة للغاية وذات جودة عالية عند مقارنتها بالدول المتقدمة الأخرى حيث تكلفتها أعلى بعشرة أضعاف كما هو الحال في الولايات المتحدة الأمريكية ، إذا قارنا تكلفة جراحة دمج العمود الفقري مع الدول الأخرى ، فإنها تكاد تكون جزءًا بسيطًا من التكلفة الفعلية يحصل شخص ما على نظرائه الغربيين في العالم وهذا هو السبب الأكبر ، لماذا يتجول الكثير من الناس لإجراء جراحة العمود الفقري في الهند.
spineneuro

স্পাইনাল ফিউশন ইন্ডিয়ার জন্য শীর্ষ হাসপাতাল আপনার পিঠের ব্যথা চিরতরে ঠিক করবে - 0 views

healthtourtoindiafrombangladesh.blogspot.com/...ix-your-back-pain-forever.html

স্পাইনাল ফিউশন সার্জারি খরচ ভারতে ভারতে স্পাইনাল ফিউশন সার্জারি স্পাইনাল ফিউশন সার্জারি

shared by spineneuro on 21 Dec 21 - No Cached
  • spineneuro on 21 Dec 21
     
    স্পাইনাল ফিউশন সার্জারি খরচ ভারতে সাশ্রয়ী মূল্যে সঞ্চালিত হয়, সর্বোত্তম উপলব্ধ চিকিত্সা প্রযুক্তি সহ। মেরুদণ্ডের ফিউশন অস্ত্রোপচারের জন্য ভারতে বেশিরভাগ পশ্চিমা দেশগুলিতে তাদের সমকক্ষের তুলনায় শুধুমাত্র একটি ভগ্নাংশ খরচ হয়। অনুগ্রহ করে আমাদের সাথে যোগাযোগ করুন আমাদের এখানে কল করুন: +91-9325887033 অথবা enquiry@spineandneurosurgeryhospitalindia.com এ আমাদের মেইল করুন
spineneuro

French to India Medical Travel: Les meilleurs hôpitaux pour Spinal Fusion Ind... - 0 views

frenchtoindiamedicaltravel.blogspot.com/...ix-your-back-pain-forever.html

Coût de la chirurgie de fusion vertébrale en Inde Chirurgie de fusion vertébrale meilleurs hôpitaux pour la fusion vertébrale Inde

shared by spineneuro on 15 Dec 21 - No Cached
  • spineneuro on 15 Dec 21
     
    Coût de la chirurgie de fusion vertébrale L'Inde est réalisée à des coûts abordables, avec la meilleure technologie de traitement disponible. Le coût de la chirurgie de fusion vertébrale en Inde ne représente qu'une fraction de celui de leurs homologues dans la plupart des pays occidentaux. Contactez-nous Appelez-nous au : +91-9325887033 Ou écrivez-nous à enquiry@spineandneurosurgeryhospitalindia.com
spineneuro

বাংলাদেশ স্বাস্থ্য নিউজ আপডেট - সংবাদ মাধ্যম: স্পাইনাল ফিউশন সার্জারি ইন্ডিয়... - 0 views

bangladeshhealthnews.blogspot.com/...inal-fusion-surgery-india.html

স্পাইনাল ফিউশন সার্জারির খরচ স্পাইনাল ফিউশন সার্জারি মেরুদণ্ডের সংমিশ্রণ

shared by spineneuro on 18 Apr 22 - No Cached
  • spineneuro on 18 Apr 22
     
    এই মেরুদন্ডের ফিউশন সার্জারির খরচ অন্যান্য উন্নত দেশগুলির সাথে তুলনা করলে উচ্চ মানের সাথে খুব সাশ্রয়ী হয় যেখানে এটি মার্কিন যুক্তরাষ্ট্রের তুলনায় 10 গুণ বেশি খরচ করে।
spineneuro

الخبرات الطبية العربية الحقيقية في الهند: ابدأ رحلة جديدة من حياة خالية من ال... - 0 views

arabrealmedicalexperiences.blogspot.com/...inal-fusion-surgery-india.html

تكلفة جراحة دمج العمود الفقري جراحة دمج الفقرات التعافي من جراحة دمج الفقرات

shared by spineneuro on 22 Apr 22 - No Cached
  • spineneuro on 22 Apr 22
     
    عادة ما تكون تكلفة جراحة دمج العمود الفقري أقل بنسبة 25-50٪ من تكلفة العلاج المكافئ في الغرب. تكاليف جراحة دمج العمود الفقري منخفضة التكلفة وجزءًا بسيطًا مما تدفعه عادةً في الدول الغربية المتقدمة.
« First ‹ Previous 181 - 200 of 205 Next ›
Showing 20▼ items per page