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Nathan Goodyear

Cristina Sanchez | Complutense University of Madrid, Madrid | UCM | Department of Bioch... - 0 views

www.researchgate.net/...Cristina_Sanchez5

cancer cannabinoids THC CBD Cristina Sanchez

shared by Nathan Goodyear on 18 Sep 18 - No Cached
  • Nathan Goodyear on 18 Sep 18
     
    Cristin sanchez publications in the use of cannabinoids in cancer.
Nathan Goodyear

Broad targeting of angiogenesis for cancer prevention and therapy - 0 views

www.ncbi.nlm.nih.gov/...PMC4737670

cancer curcumin VEGF EGCG green tea melatonin quercetin Resveratrol silymarin flavonoids HIF-1alpha

shared by Nathan Goodyear on 01 Jun 18 - No Cached
  • vascular endothelial growth factor (VEGF), fibroblast growth factor-2 (FGF-2), interleukin-8 (IL-8), placental growth factor (PlGF), transforming growth factor-beta (TGFbeta), platelet derived growth factor (PDGF), angiopoietins (Angs) and others (reviewed in [4])
  • The switch may also involve down-regulation of endogenous inhibitors of angiogenesis such as endostatin, angiostatin or thrombospondin (reviewed in [5]) and has thus been regarded as the result of tipping the net balance between positive and negative regulators
  • There is a complex interrelationship between tumor hypoxia and tumor angiogenesis
  • ...17 more annotations...
  • chronic hypoxia
  • acute hypoxia
  • Environmental stress as a result of low oxygen and proper nutrient deprivation, such as glucose deprivation, are capable of inducing VEGF mRNA stabilization resulting in increased levels of the secreted ligand and angiogenic growth
  • HIFalpha subunits accumulate in the cytoplasm where they bind HIFbeta to form a heterodimer that subsequently translocates to the nucleus to activate transcription of target genes, including genes important for various processes such as metabolism (glucose transporter (GLUT)-1, hexokinase (HK)-1), cell growth (cyclin (CCN)-D1 [23]) and also angiogenesis, such as erythropoietin, VEGF and PDGF [24] (summarized in Fig. 1)
  • When oxygen levels are low (hypoxia; red arrow) PHDs cannot hydroxylate HIFalphas thereby allowing them to escape pVHL-mediated degradation. HIFalpha subunits accumulate and bind to their heterodimeric partner, HIFbeta, translocate into the nucleus and activate a cascade of hypoxic signaling first by the transcription of various target genes including microRNAs that are important for tumor promoting pathways
  • c-Src is also capable of activating HIFs by indirectly inhibiting PHD activity via the NADPH oxidase/Rac pathway.
  • mTOR can also promote stabilization and HIF transcriptional activity
  • hypoxia inducible factors (HIFs), heterodimeric transcription factors composed from alpha and beta subunits, which can be rapidly stabilized to fluidly adapt to and overcome the effects of a hypoxic environment
  • Curcumin inhibits the expression of epidermal growth factor receptor (EGFR), VEGFR-1, VEGFR-2 and VEGFR-3, and the kinase activity of Src and FAK, which are responsible for the induction of angiogenic genes as well as endothelial cell polarity and migration
  • Curcumin also reduces the MMP-2 and MMP-9 expression, along with the suppression of growth and invasion potential of tumor cells in culture and xenograft experiments
  • The expression of angiogenic biomarkers COX-2 and serum levels of VEGF were significantly reduced in the curcumin-treated group
  • Resveratrol inhibits capillary endothelial cell growth and new blood vessel growth in animals
  • interrupting cell proliferation, inducing apoptosis
  • [155] and impeding angiogenesis by suppressing VEGF expression through down-regulation of HIF-1alpha
  • resveratrol was reported to inhibit cell proliferation of human ovarian cancer cells and human osteosarcoma cells by attenuating HIF-1alpha
  • prevents cytokine-induced vascular leakage and tumor metastasis
  • The underlying molecular mechanisms include: blocking VEGF- and FGF-receptor-mediated MAPK activation, inhibiting Akt- and MAPK-driven HIF-1alpha basal expression and its induction by IGF-1, stimulating the proteasomal degradation of HIF-1alpha, inhibiting phosphatidyl inositol (PI)-3K/Akt and Ras/mitogen/extracellular signal-regulated kinase (MEK)/ERK pathways, and activation of forkhead box (FOX)O transcription factors
  • Nathan Goodyear on 01 Jun 18
     
    natural compounds to attach cancer explained.
Nathan Goodyear

[Post-operative suppression of natural killer activity] | Request PDF - 0 views

www.researchgate.net/...ion_of_natural_killer_activity

surgery NK cells cancer

shared by Nathan Goodyear on 04 Jun 18 - No Cached
  • Nathan Goodyear on 04 Jun 18
     
    Surgery found to decrease NK cell activity out to 14 days.
Nathan Goodyear

(PDF) Does the mobilization of circulating tumour cells during cancer therapy cause met... - 0 views

www.researchgate.net/...ancer_therapy_cause_metastasis

chemotherapy metastasis

shared by Nathan Goodyear on 15 Apr 20 - No Cached
  • Nathan Goodyear on 15 Apr 20
     
    Chemotherapy induced metastasis. It does happen.
Nathan Goodyear

(PDF) Artesunate Attenuates Pro-Inflammatory Cytokine Release from Macrophages by Inhib... - 0 views

www.researchgate.net/...e_TRAF6-Beclin1-PI3KC3_Pathway

artesunate cytokine storm sepsis

shared by Nathan Goodyear on 04 Apr 20 - No Cached
  • Nathan Goodyear on 04 Apr 20
     
    To be read
Nathan Goodyear

Antimalarial artesunate protects sepsis model mice against heat-killed Escherichia coli... - 0 views

www.researchgate.net/...ription_factor_NF-B_activation

inflammation artesunate LPS TLR-4 TLR4

shared by Nathan Goodyear on 17 Apr 20 - No Cached
  • Nathan Goodyear on 17 Apr 20
     
    Artesunate inhibits TLR-4 expression to block LPS induced pro-inflammatory response.
Nathan Goodyear

Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by... - 0 views

www.researchgate.net/...r_by_a_dual_COX-2sEH_inhibitor

chemotherapy COX2 ovarian cancer COX-2 cytokine storm

shared by Nathan Goodyear on 06 Apr 20 - No Cached
  • Nathan Goodyear on 06 Apr 20
     
    COX2 inhibition used to counter chemotherapy induced cytokine storm metastasis.
healthwiseindian

Diet tips for healthy weight loss - 0 views

www.slideshare.net/HealthWiseIndian

Weight loss motivation healthy weight loss tips Diet for weight loss diet plan for weight loss diet chart for weight loss how to lose weight weight loss tips weight loss healthy eating how to reduce weight healthy diet healthy food diet plans eating healt

shared by healthwiseindian on 02 Nov 17 - No Cached
  • healthwiseindian on 02 Nov 17
     
    Weight loss is an important topic of worry. Not all kinds of dieting practices are helpful in achieving a healthy weight loss. Follow the advice of Dr. Binita who has compiled a comprehensive study about weight loss. At Healthwise Indian, we help in giving health guidance to people in order to improve their lifestyle.
Nathan Goodyear

Vitamin C inhibits NO-induced stabilization of HIF-1alpha in HUVECs | Request PDF - 0 views

www.researchgate.net/...zation_of_HIF-1alpha_in_HUVECs

Hypoxia-inducible Factor 1 HIF-1alpha vitamin C nitric oxide HIF-1 NO

shared by Nathan Goodyear on 01 Apr 21 - No Cached
  • Nathan Goodyear on 01 Apr 21
     
    Only abstract available. NO increases accumulation of HIF-1alpha and Loading of the cells with vitamin C counteracted NO-induced HIF-1alpha accumulation. It is the HIF-1alpha and HIF-1beta combination that will change genetic expression (epigenetics)
Nathan Goodyear

(PDF) Hyperthermia Sensitizes Glioma Stem Cells to Radiation by Inhibiting AKT - 0 views

www.researchgate.net/...to_Radiation_by_Inhibiting_AKT

Akt Hyperthermia radiation

shared by Nathan Goodyear on 02 Apr 21 - No Cached
  • Nathan Goodyear on 02 Apr 21
     
    Hyperthermia increases radio sensitivity of cancer through inhibition of Akt.
Nathan Goodyear

Improved liver function after high dose intravenous vitamin C and Helxior SC injections... - 0 views

www.researchgate.net/...chemotherapy-and-radiation.pdf

metastasis high dose vitamin C IV vitamin C High dose IV vitamin C hepatocellular carcinoma cancer hepatocellular cancer vitamin C

shared by Nathan Goodyear on 09 Mar 21 - No Cached
  • Nathan Goodyear on 09 Mar 21
     
    HDIVC plus mistletoe SQ improved and stabilized a patient with advanced hepatocellular carcinoma.
Nathan Goodyear

Metronomic Chemotherapy in Non-Small-Cell Lung Cancer | Request PDF - 0 views

www.researchgate.net/..._in_Non-Small-Cell_Lung_Cancer

low-dose low-dose chemotherapy metronomic chemotherapy LDMC lung cancer

shared by Nathan Goodyear on 29 Apr 21 - No Cached
  • Nathan Goodyear on 29 Apr 21
     
    LDMC effect in lung cancer via its Antiangiogenic and anti immunosuppressive effects.
Nathan Goodyear

Low triiodothyronine syndrome as a predictor of poor outcomes in patients undergoing br... - 0 views

www.researchgate.net/...in_tumor_surgery_A_pilot_study

T3 non-thyroidal illness syndrome euthyroid sick syndrome brain tumor cancer surgery

shared by Nathan Goodyear on 15 Mar 21 - No Cached
  • Nathan Goodyear on 15 Mar 21
     
    Low T3 poor predictor pre-surgery for those with brain tumor.
Nathan Goodyear

Natural products as important tyrosine kinase inhibitors - 0 views

dacemirror.ggws.net/...yin2019.pdf

natural therapy cancer tyrosine kinase natural therapies natural medicine tyrosine kinase inhibitors

shared by Nathan Goodyear on 16 Mar 21 - No Cached
  • Nathan Goodyear on 16 Mar 21
     
    Good review of some natural products that have been shown to inhibit tyrosine kinase activity.
Nathan Goodyear

Curcumin Attenuates Cr(VI)-Induced Ascites and Changes in the Activity of Aconitase and... - 0 views

www.researchgate.net/...tent_in_Rat_Liver_Mitochondria

ascites curcumin cancer

shared by Nathan Goodyear on 07 Apr 21 - No Cached
  • Nathan Goodyear on 07 Apr 21
     
    Curcumin decreased ascites formation
Nathan Goodyear

Reducing malignant ascites accumulation by repeated intraperitoneal administrations of ... - 0 views

www.researchgate.net/...ions_of_a_Viscum_album_extract

Intra-peritoneal ascites cancer mistletoe

shared by Nathan Goodyear on 07 Apr 21 - No Cached
  • Nathan Goodyear on 07 Apr 21
     
    Intra-peritoneal v. Mali used to treat malignant ascites.
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