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Nathan Goodyear

Lipid-Based Diets Improve Muscarinic Neurotransmission in the Hippocampus of Transgenic... - 0 views

www.eurekaselect.com/...article

lipids fat high fat diet ketogenic diet brain alzheimer's disease brain health nutrition

shared by Nathan Goodyear on 15 Feb 16 - No Cached
  • Nathan Goodyear on 15 Feb 16
     
    Proof of concept study in Alzheimer's model finds high fat diet improves brain cholinergic synapses, targeting directly the neurotransmission deficits in Alzheimer's disease
Nathan Goodyear

Low carbohydrate diets improve atherogenic dyslipidemia even in the absence of weight loss - 0 views

www.ncbi.nlm.nih.gov/...PMC1488852

ketogenic diet low carbohydrate diet diet nutrition atherosclerosis cholesterol HDL LDL Triglycerides

shared by Nathan Goodyear on 09 Feb 18 - No Cached
mamdouh_hfz liked it
  • Nathan Goodyear on 09 Feb 18
     
    low carb diet found to benefit atherosclerosis and lipid abnormalities (Triglycerides, HDL, and LDL particle size).  Interesting enough, no significant weight loss was seen.
Nathan Goodyear

The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for ... - 0 views

nutritionandmetabolism.biomedcentral.com/...s12986-015-0009-2

cancer GKI glucose ketone index ketogenic diet nutrition

shared by Nathan Goodyear on 02 Apr 18 - No Cached
  • The ‘Glucose Ketone Index’ (GKI) was created to track the zone of metabolic management for brain tumor management
  • The GKI is a biomarker that refers to the molar ratio of circulating glucose over β-OHB, which is the major circulating ketone body.
  • We present evidence showing that the GKI can predict success for brain cancer management in humans and mice using metabolic therapies that lower blood glucose and elevate blood ketone levels
  • ...14 more annotations...
  • The GKI can be useful in determining the success of dietary therapies that shift glucose- and lactate-based metabolism to ketone-based metabolism
  • Alzheimer’s disease, Parkinson’s disease, traumatic brain injury, chronic inflammatory disease, and epilepsy
  • The zone of metabolic management is likely entered with GKI values between 1 and 2 for humans
  • Optimal management is predicted for values approaching 1.0, and blood glucose and ketone values should be measured 2–3 hours postprandial, twice a day if possible
    • Nathan Goodyear
      Nathan Goodyear on 09 May 18
       
      check GKI 2-3 hr postprandial twice daily
  • Preclinical studies have demonstrated a clear linkage between GKI and therapeutic efficacy
  • the Warburg effect (aerobic fermentation of glucose) is a common metabolic malady expressed in nearly all neoplastic cells of these and other malignant tumors
  • Aerobic fermentation (Warburg effect) is necessary to compensate for the insufficiency of mitochondrial oxidative phosphorylation in the cells of most tumors
  • Normal brain cells gradually transition from the metabolism of glucose to the metabolism of ketone bodies (primarily β-hydroxybutyrate and acetoacetate) for energy when circulating glucose levels become limiting
  • Ketone bodies bypass the glycolytic pathway in the cytoplasm and are metabolized directly to acetyl CoA in the mitochondria
  • Tumor cells are less capable than normal cells in metabolizing ketone bodies for energy due to their mitochondrial defects
  • daily activities and emotional stress can cause blood glucose levels to vary making it difficult for some people to enter the predicted zone of metabolic management
  • a clear association of the GKI to the therapeutic action of calorie restriction against distal invasion, proliferation, and angiogenesis in the VM-M3 model of glioblastoma
  • The results suggest that GKI levels that approach 1.0 are therapeutic for managing brain tumor growth
  • Therapeutic efficacy of the KD or calorie restriction is greater with lower GKI values than with higher values
  • Nathan Goodyear on 02 Apr 18
     
    The glucose ketone index shown to predict dietary metabolic success. In humans with brain cancer-- the target is 1.  The glucose and ketone (betahydroxybutyrate) should be measured 2-3 hours postprandial twice daily.
harshitatyagi

Can Keto Diet Lead You To Positive Pregnancy Results - 0 views

fortunetelleroracle.com/...itive-pregnancy-results-652446

Keto Diet Ketogenic Diet Low Carbohydrate Diet Keto Food Keto diet for weigh loss Pregnancy

shared by harshitatyagi on 24 Aug 22 - No Cached
  • harshitatyagi on 24 Aug 22
     
    A keto diet with its modification can reduce the challenges of infertility. And make the couple's fertility so they can relieve their abandoned dream of being a parent again.
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