Activation of NK cells by extracellular heat shock protein 70 through induction of NKG2... - 0 views
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Heat shock proteins (HSPs) are intracellular molecular chaperones that play essential roles in facilitating protein folding
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their ability to interact with APCs and to chaperone antigenic peptides for cross-presentation to MHC class I and class II molecules on APC
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vaccination with HSP70 was associated with increased T cell, as well as NK cell, activity in patients with CML
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HSP70 did not activate NK cells directly. Instead, HSP70 induced the expression of an NKG2D ligand MICA on DCs, which then activated NK cells in an NKG2D-dependent manner.
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DCs are the most powerful professional antigen presenting cells (APCs) that are instrumental in processing antigens and orchestrating antigen-specific adaptive immunity and tolerance
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The magnitude of the IFN-γ response was different from patient to patient and correlated with the number of functional NK cells
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In addition, 10 out of 14 patients had significantly increased IFN-γ producing cells in the peripheral blood after HSP70 vaccinations, which is again in line with increased NK cell activity as reported in our original study in these patients