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Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells b... - 0 views

www.pnas.org/1918 cancer HDM-2 PNC27 PNC-27
shared by Nathan Goodyear on 14 Aug 21 - No Cached
  • Nathan Goodyear on 14 Aug 21
     
    PNC-27 induces pore formation in cancer cell membranes via the HDM-2 binding domain.
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Anti-Cancer Tumor Cell Necrosis of Epithelial Ovarian Cancer Cell Lines Depends on High... - 0 views

pubmed.ncbi.nlm.nih.gov/33067207 ovarian cancer peptides cancer PNC27 PNC-27 HDM-2
shared by Nathan Goodyear on 14 Aug 21 - No Cached
  • Nathan Goodyear on 14 Aug 21
     
    PNC-27 binds to HDM-2 which is highly expressed on ovarian cancer cancer cell lines. The result is transmembrane pore formation and apoptosis independent cell necrosis.
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Targeting Membrane HDM-2 by PNC-27 Induces Necrosis in Leukemia Cells But Not in Normal... - 0 views

ar.iiarjournals.org/...4857.long PNC-27 cancer PNC27 p53 HDM-2 peptides
shared by Nathan Goodyear on 14 Aug 21 - No Cached
  • Nathan Goodyear on 14 Aug 21
     
    PNC-27 induces cancer cell necrosis via HDM-3 binding domain from p53, but not in non-malignant cells.
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Anti-cancer peptides from ras-p21 and p53 proteins - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/21728981 PNC27 PNC-28 peptides PNC28 cancer p53 PNC PNC-27
shared by Nathan Goodyear on 14 Aug 21 - No Cached
  • Nathan Goodyear on 14 Aug 21
     
    PNC-27 and 28, contain HDM-2-protein-binding domain sequences from the tumor suppressor p53 to induce pore formation in the membranes of a wide range of cancer cells but not any normal cells tested
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