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Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes | PNAS - 0 views

www.pnas.org/1918

cancer HDM-2 PNC27 PNC-27

shared by Nathan Goodyear on 14 Aug 21 - No Cached

Nathan Goodyear on 14 Aug 21

PNC-27 induces pore formation in cancer cell membranes via the HDM-2 binding domain.

<div class="cArrow"> </div><div class="cContentInner">PNC-27 induces pore formation in cancer cell membranes via the HDM-2 binding domain. </div>

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Anti-Cancer Tumor Cell Necrosis of Epithelial Ovarian Cancer Cell Lines Depends on High Expression of HDM-2 Protein in Their Membranes - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/33067207

ovarian cancer peptides cancer PNC27 PNC-27 HDM-2

shared by Nathan Goodyear on 14 Aug 21 - No Cached

Nathan Goodyear on 14 Aug 21

PNC-27 binds to HDM-2 which is highly expressed on ovarian cancer cancer cell lines. The result is transmembrane pore formation and apoptosis independent cell necrosis.

<div class="cArrow"> </div><div class="cContentInner">PNC-27 binds to HDM-2 which is highly expressed on ovarian cancer cancer cell lines. The result is transmembrane pore formation and apoptosis independent cell necrosis. </div>

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Targeting Membrane HDM-2 by PNC-27 Induces Necrosis in Leukemia Cells But Not in Normal Hematopoietic Cells | Anticancer Research - 0 views

ar.iiarjournals.org/...4857.long

PNC-27 cancer PNC27 p53 HDM-2 peptides

shared by Nathan Goodyear on 14 Aug 21 - No Cached

Nathan Goodyear on 14 Aug 21

PNC-27 induces cancer cell necrosis via HDM-3 binding domain from p53, but not in non-malignant cells.

<div class="cArrow"> </div><div class="cContentInner">PNC-27 induces cancer cell necrosis via HDM-3 binding domain from p53, but not in non-malignant cells. </div>

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Anticancer peptide PNC-27 adopts an HDM-2-binding conformation and kills cancer cells by binding to HDM-2 in their membranes - 0 views

www.ncbi.nlm.nih.gov/...PMC2836618

cancer PNC-27 HDM-2 PNC27

shared by Nathan Goodyear on 14 Jul 21 - No Cached

Anti-cancer peptides from ras-p21 and p53 proteins - PubMed - 0 views

pubmed.ncbi.nlm.nih.gov/21728981

PNC27 PNC-28 peptides PNC28 cancer p53 PNC PNC-27

shared by Nathan Goodyear on 14 Aug 21 - No Cached

Nathan Goodyear on 14 Aug 21

PNC-27 and 28, contain HDM-2-protein-binding domain sequences from the tumor suppressor p53 to induce pore formation in the membranes of a wide range of cancer cells but not any normal cells tested

<div class="cArrow"> </div><div class="cContentInner">PNC-27 and 28, contain HDM-2-protein-binding domain sequences from the tumor suppressor p53 to induce pore formation in the membranes of a wide range of cancer cells but not any normal cells tested</div>

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The Anti-Cancer Peptide, PNC-27, Induces Tumor Cell Necrosis of a Poorly Differentiated Non-Solid Tissue Human Leukemia Cell Line that Depends on Expression of HDM-2 in the Plasma Membrane of these Cells - 0 views

www.annclinlabsci.org/...241.long

cancer peptides PNC27 PNC-27

shared by Nathan Goodyear on 14 Aug 21 - No Cached

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