d-chiro-inositol levels shown to be low in diabetics. Thus, d-chiro-inositol would prove to be helpful in diabetes management. D-chiro-inositol is a secondary messenger in insulin signaling
Myo-inositol and D-chiro-inositol improve metabolic function in women with PCOS. Myo-inositol appears to have better effects on metabolic profile and D-chiro-inositol on reduced androgen effects.
women with the polycystic ovary syndrome, D-chiro-inositol reduces circulating insulin, decreases serum androgens, and ameliorates some of the metabolic abnormalities (increased blood pressure and hypertriglyceridemia) of syndrome X.
Chiro-inositol increases the action of insulin in patients with the polycystic ovary syndrome, thereby improving ovulatory function and decreasing serum androgen concentrations, blood pressure, and plasma triglyceride concentrations.
The metabolism of DCI is associated with insulin sensitivity and resistance, supporting the concept that second messengers have a role in responses to and resistance to insulin.