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star yu

Calambres Musculares Constantes para Niños con Síndrome Nefrótico - 0 views

www.enfermedad-renal.com/...2162.html

Calambres Musculares Constantes

shared by star yu on 06 Apr 15 - No Cached
  • star yu on 06 Apr 15
     
    Calambres musculares constantes, especialmente en las piernas son síntoma común en los niños con síndrome nefrótico
Nathan Goodyear

Endocrinology of the Aging Male - 0 views

www.ncbi.nlm.nih.gov/...PMC3073592

aging male hormone hormones

shared by Nathan Goodyear on 30 Apr 13 - No Cached
  • All steps beyond the formation of pregnenolone take place in the smooth endoplasmic reticulum
  • Cytochrome P450 enzyme, CYP11A is located on the inner mitochondrial membrane and catalyses the rate limiting step of pregnenolone synthesis
  • Estrogen and related steroids, thyroid hormone and insulin increase SHBG levels.
  • ...21 more annotations...
  • SHBG decreases in response to androgens, and in the presence of hypothyroidism, and insulin resistance.
  • Plasma SHBG levels tend to increase with increasing age
  • The apparent metabolic clearance rate of testosterone is decreased in elderly as compared to younger men
  • Testosterone circulates predominantly bound to the plasma proteins SHBG and albumin, with high and low affinity respectively
  • Testosterone is secreted in a pulsatile fashion
  • Current clinical guidelines suggest at least two measurements
  • In adult men, there is a well-documented diurnal variation (particularly in younger subjects) in testosterone levels, which are highest in the early morning and progressively decline throughout the day to a nadir in the evening
  • In older men, the diurnal variation is blunted
  • it is standard practice for samples to be obtained between 0800 and 1100 h.
  • Testosterone and DHEA decline, whereas LH, FSH, and SHBG rise
  • DHT remains constant despite the decline of its precursor testosterone
  • Longitudinal studies show an average annual decline of 1–2% total testosterone levels, with decline in free testosterone more rapid because of increases in SHBG with aging
  • Massachusetts Male Aging Study (MMAS) data show DHEA, DHEAS, and Ae declining at 2–3% per year
  • DHT showed no cross-sectional age trend
  • Androstanediol glucuronide (AAG) declined cross-sectionally with age in the MMAS sample, at 0.6% per year
  • The EMAS data show that, consistent with the longitudinal findings of MMAS (Figure 1), the core hormonal pattern with increasing age is suggestive of incipient primary testicular dysfunction with maintained total testosterone and progressively blunted free testosterone associated with higher LH
    • Nathan Goodyear
      Nathan Goodyear on 01 May 13
       
      This author proves the point in the review of these two studies, that TT may remain constant in aging men, however, FT drops.
  • obesity impairs hypothalamic/pituitary function
  • Androgen deprivation in men with prostate cancer has been associated with increased insulin resistance, worse glycemic control, and a significant increase in risk of incident diabetes
  • Low serum testosterone is associated with the development of metabolic syndrome 116, 117 and type 2 diabetes. 118 SHBG has been inversely correlated with type 2 diabetes
  • Improvement in insulin sensitivity with testosterone treatment has been reported in healthy 121 and diabetic 122 adult men
  • In studies conducted in men with central adiposity, testosterone has been shown to inhibit lipoprotein lipase activity in abdominal adipose tissue leading to decreased triglyceride uptake in central fat depots. 123
  • Nathan Goodyear on 30 Apr 13
     
    great review of hormone changes associated with aging in men.
Smile Reef

Enjoying Halloween Treats While Ensuring Children's Dental Health - Smile Reef Pediatri... - 0 views

smilereef.com/...suring-childrens-dental-health

dental dentist dentistry

shared by Smile Reef on 01 Nov 12 - No Cached
  • Smile Reef on 01 Nov 12
     
    Every child loves Halloween. It's always a fun time to go out in costume and get treats. If they are lucky they are bound to take home a bag full of candy. That is always good for the kids, but bad for their dental health. Taking care of children's dental health can already be a challenge for some without the constant temptation of sweets.
wheelchairindia9

Hernia Belt - 0 views

www.wheelchairindia.com/...Tynor-Hernia-Belt

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shared by wheelchairindia9 on 02 Apr 16 - No Cached
  • wheelchairindia9 on 02 Apr 16
     
    Tynor Hernia Belt Hernia belt offers a gentle and constant relief from reducible inguinal hernia by providing adjustable and comfortable pressure to the hernia. On wearing the belt the occurrence of herniation gets eliminated. Tynor hernia belt is available in skin color, can be worn inconspicuously under clothing. Moulded foam pads. Adjustable leg and abdominal strap. Soft and skin friendly materials. Controlled pressure. Tynor Hernia Belt Features Anatomic pads Presses the inguinal aperture at the appropriate angle, enhances the effectiveness. Molded out of special grade ethafoam Appropriate hardness, light weight, smooth and comfortable. Grey color product Can be worn inconspaciously under cloth, aesthetically pleasing. Soft and dermophilic materials No rash no allergy, very comfortable, improve compliance. Adjustable pelvic and leg straps One size fits a large population, controlled & customized pressure possible. Tynor Hernia Belt Measurements Measure circumference around the waist 2 inches below the navel.
Nathan Goodyear

Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Me... - 0 views

press.endocrine.org/...jcem.86.2.7219

low t low Testosterone Testosterone SHBG FAI free androgen index male hormone hormones aging obesity

shared by Nathan Goodyear on 30 Mar 15 - No Cached
  • NUMEROUS CROSS-SECTIONAL INVESTIGATIONS have demonstrated lower concentrations of circulating testosterone (T) and/or free T in older men
  • Two small-scale longitudinal investigations have observed decreases, with aging, in total T
  • T levels decline at a more or less constant rate, with age, in men, with no period of accelerated decline
  • ...15 more annotations...
  • aging in men is associated with decreases in bone mineral density (BMD) (18, 19), lean body and muscle mass
  • strength (22, 23) and aerobic capacity (24), as well as with increases in total and abdominal body fat, low-density lipoprotein cholesterol, and/or low-density lipoprotein/high-density lipoprotein cholesterol ratios (25, 26, 27, 28), all of which also occur in nonelderly hypogonadal men
  • Most (1, 5, 6, 7, 8, 9), but not all (10, 11, 12), cross-sectional studies have demonstrated a decrease, with age, in total T in men
    • Nathan Goodyear
      Nathan Goodyear on 30 Mar 15
       
      FAI: 100 x total Testosterone nmol/L/SHBG nmol/L
    • Nathan Goodyear
      Nathan Goodyear on 30 Mar 15
       
      These numbers do point to an increase in ng/dl decline in Total Testosterone with increasing age (decade group)
  • total T, but not free T index, tended to decrease with greater BMI is consistent with prior studies showing that obesity is associated with decreases in both SHBG and total T, with an unchanged T-to-SHBG ratio
  • The conventional definition for T levels is statistical (values more than 2 sd below the mean), rather than functional. Such a definition does not reflect clinical realities, such as the existence of characteristic individual set points for circulating hormone levels, below which one, but not another, individual may develop metabolic changes of hormone deficiency; nor does it address the concept of reserve capacity, the possibility that persons with hormone levels 2 sd below the population mean still may have adequate hormone concentrations to meet their metabolic needs.
    • Nathan Goodyear
      Nathan Goodyear on 30 Mar 15
       
      good explanation of problems with just using a number to define low T
  • both T and free T index (a calculated value related to free or bioavailable T) decreased progressively at a rate that did not vary significantly with age, from the third to the ninth decades.
  • contrasts with other studies showing diminished free, as well as total, T in with increasing total (48) or abdominal (49) obesity in men.
  • Our analysis of date-adjusted T and free T index levels, by decade, showed that relatively high numbers of older men in this generally healthy population had at least one hypogonadal value (defined as below the 2.5th percentile for young men)
  • The issue of how properly to define hypogonadism, or indeed any hormone deficiency, remains problematic
  • The decrease in free T index was somewhat steeper than that of total T, owing to a trend for an increase in SHBG with age
  • LH for gonadal function
  • It would clearly be better to define the lower limit of normal for a hormone as: the blood level at which metabolic and/or clinical sequelae of hormone deficiency begin to appear, or the level below which definite benefits can be demonstrated for hormone supplementation for a significant proportion of the population
  • an effect of aging to lower both total and bioavailable circulating T levels at a relatively constant rate, independent of obesity, illness, medications, cigarette smoking, or alcohol intake
  • Nathan Goodyear on 30 Mar 15
     
    Article highlights the problems with the definition of low T.  This article finds consistent decline in Total Testosterone and FAI with increasing age groups, with a significant portion of men > 60 meeting the required levels for "low T".  This study found a decrease in total T and FAI at a consistent rate independent of variables, such as BMI.    This study did find a decrease in SHBG and total T with obesity; in contrast to other studies.
star yu

La Terapia con Células Madre es un Tratamiento Alternativo la Diálisis para l... - 0 views

www.hospitalrenal.com/...1343.html

función renaltratamientola diálisisla terapia con células madrelos efectos secundarios

shared by star yu on 27 Mar 16 - No Cached
  • star yu on 27 Mar 16
     
    Los pacientes con CKD no quieren tomar la diálisis, eso es un problema constante. Los pacientes nesecitan saber un asunto que la terapia con células madre es un tratamiento alternativo la diálisis ahora. No se preocupan de esta terapia es eficaz o no. En esta artículo, le daremos una respuesta acerca de esta terapia.
  • star yu on 28 Mar 16
     
    Los pacientes con CKD no quieren tomar la diálisis, eso es un problema constante. Los pacientes nesecitan saber un asunto que la terapia con células madre es un tratamiento alternativo la diálisis ahora. No se preocupan de esta terapia es eficaz o no. En esta artículo, le daremos una respuesta acerca de esta terapia.
indiacardiacsurg

New Vacuum Stabilizer System for CABGG Surgery Procedure Introduced in India - 0 views

www.briefingwire.com/...-procedure-introduced-in-india

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shared by indiacardiacsurg on 29 Nov 21 - No Cached
  • indiacardiacsurg on 29 Nov 21
     
    India's best CABG surgeons perform hundreds of open-heart surgeries every year. The talent and experience of the team afford the foundation for constant excellent patient outcomes, including lower than expected mortality rates in several surgical categories. CABG surgery in India International Helpline Number : +91-9370586696 Email id:enquiry@indiacardiacsurgerysite.com
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https://www.fitspresso-co.com/ - 0 views

www.fitspresso-co.com

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shared by fitspresso on 27 Sep 23 - No Cached
  • fitspresso on 27 Sep 23
     
    FitSpresso™ | Official Site fitspresso-co.com FitSpresso Only $39/Bottle Limited Time Offer! FitSpresso Special Deal + Special 51% Discount Save $660 + 180 Days Money Back Guarantee FitSpresso Herpesyl Five Star A dietary product formulated to assist users in reducing weight can increase other advantages that can support overall health. This product can assist users in getting closer to the desirable body weight. Regular Price: 149/per bottle Only for: $39/per bottle Buy Now What IsFitSpresso? FitSpresso is promoted as a natural supplement that comes in the form of diet pills, and it can aid in rapid and efficient weight loss, similar to many other supplements. The term "natural supplements refers to a nutritional supplement that is made entirely of natural, chemical-free materials. You can utilize these organic ingredients to aid in natural weight loss. It can speed up your body's metabolism and assist with other crucial processes. All parts of our bodies are impacted by weight increase, and not only do we need to deal with the increased weight, but we also need to deal with the numerous problems and illnesses that come along with it. This refers to the risk of developing chronic cardiac conditions, low blood pressure, and, in some circumstances, problems with blood sugar. However, FitSpresso even with its bright and bold claims, can help you efficiently manage your weight and completely avoid these extra uncomfortable problems. FitSpresso is a supplement that comes in the form of a pill, which makes it tasty, simple to swallow, and handy. According to the manufacturer, these diet tablets are GMO-free and toxic-free, making them edible. This is why we have things such as weight loss supplements. Thanks to modern advancements, we can just take a dietary supplement pill to bring about significant weight loss in a completely healthy and natural manner. Not only this, but dietary supplements can also support healthy blood sugar levels and help with
Nathan Goodyear

Plasma lipoproteins: composition, structure and biochemistry - 0 views

lipidlibrary.aocs.org/...index.htm

apolipoproteins cholesterol VLDL chylomicrons LDL HDL lipoproteins biochemistry

shared by Nathan Goodyear on 21 May 13 - No Cached
  • triacylglycerols
  • The most abundant lipid constituents are triacylglycerols, free cholesterol, cholesterol esters and phospholipids (phosphatidylcholine and sphingomyelin especially ), though fat-soluble vitamins and anti-oxidants are also transported in this way
  • the lipoprotein aggregates should be described in terms of the different protein components or apoproteins (or 'apolipoproteins'
  • ...8 more annotations...
  • Density is determined largely by the relative concentrations of triacylglycerols and proteins and by the diameters of the broadly spherical particles
  • these classes can be further refined by improved separation procedures, and intermediate-density lipoproteins (IDL) and subdivisions of the HDL (e.g. HDL1, HDL2, HDL3 and so forth
  • the main groups are classified as chylomicrons (CM), very-low-density lipoproteins (VLDL), low-density lipoproteins (LDL) and high-density lipoproteins (HDL), based on the relative densities of the aggregates on ultracentrifugation
  • the various lipid components should not be considered as absolute, as they are in a state of constant flux
  • Apo A1 is the main protein component of HDL
  • Apo A2 is the second most important HDL apolipoprotein
  • Lipoproteins are spherical (VLDL, LDL, HDL) to discoidal (nascent HDL) in shape with a core of non-polar lipids, triacylglycerols and cholesterol esters, and a surface monolayer, ~20Å thick, consisting of apoproteins, phospholipids and non-esterified cholesterol, which serves to present a hydrophobic face to the aqueous phase
  • The lipoproteins can be categorised simplistically according to their two main metabolic functions. The principal role of the chylomicrons and VLDL is to transport triacylglycerols ‘forward’ as a source of fatty acids from the intestines or liver to the peripheral tissues. In contrast, the HDL remove excess cholesterol from peripheral tissues and deliver it to the liver for excretion in bile in the form of bile acids (‘reverse cholesterol transport’). While these functions are considered separately here for convenience, it should be recognised that the processes are highly complex and inter-related, and they involve transfer of apoproteins, enzymes and lipid constituents among the heterogeneous mix of all the lipoprotein fractions.
  • Nathan Goodyear on 21 May 13
     
    Awesome review of apolipoproteins, their function, and their metabolism.
Nathan Goodyear

Understanding lipoproteins as transporters of cholesterol and other lipids - 0 views

advan.physiology.org/...105.full

lipoproteins apolipoproteins cholesterol atherosclerosis CVD CAD

shared by Nathan Goodyear on 03 Jul 13 - No Cached
  • the density of each lipoprotein is clearly in a constant state of flux
  • Two lipoprotein fractions are primarily involved in transport of lipid to peripheral tissues, very low density lipoproteins (VLDL) from the liver and chylomicrons from the intestinal tract
  • As lipid is removed from these two fractions, the density of each fraction increases, thereby transforming VLDL into intermediate-density lipoprotein (IDL) and ultimately LDL, and chylomicrons into chylomicron remnants
  • ...5 more annotations...
  • LDL-cholesterol has been described, and overly simplified, as “bad cholesterol” and HDL-cholesterol as “good cholesterol.”
  • HDL, is primarily involved in returning lipid, largely cholesterol, to the liver in a process called reverse cholesterol transport
  • Two primary subfractions of HDL have been classified as the higher-density HDL3, and the less dense, more lipid-filled HDL2
  • Recent investigations are also suggesting that smaller, denser lipoproteins are associated with increased risk of atherosclerotic development
  • lipoproteins as transporters of lipid
  • Nathan Goodyear on 03 Jul 13
     
    Brief, but good review of lipoproteins and apoliproteins.
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