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Nathan Goodyear

Comparisons of normal saline and lactated Ringer's resuscitation on hemodynamics, metab... - 0 views

www.ncbi.nlm.nih.gov/...PMC4029282

IV fluids lactated ringers normal saline LR NS

shared by Nathan Goodyear on 03 Jul 18 - No Cached
  • NS contains 154 mM Na+ and Cl-, with an average pH of 5.0 and osmolarity of 308 mOsm/L.
  • LR solution has an average pH of 6.5, is hypo-osmolar (272 mOsm/L), and has similar electrolytes (130 mM Na+, 109 mM Cl-, 28 mM lactate, etc.) to plasma
  • hyperchloremic acidosis
  • ...26 more annotations...
  • LR’s acid base balance is superior to that of NS’s
  • There were no significant differences between LR and NS groups in fibrinogen concentrations or platelet count
  • Total protein dropped
  • no significant differences in Hct (Table  1) or total protein between LR and NS groups
  • Bicarbonate HCO3- levels were decreased by hemorrhage but returned to pre-hemorrhage values by 3 h after LR resuscitation, whereas no return was observed with NS resuscitation
  • Na+ was increased after NS resuscitation
  • No changes in Na+ or K+ were observed
  • K+ did not change initially after NS resuscitation but was elevated at 6 h afterwards
  • Ca++ was similarly decreased
  • Cl- was elevated for 6 h after NS resuscitation, with no changes shown after LR resuscitation
  • PT was similarly prolonged by resuscitation with LR (from 11.2 ± 0.2 sec at baseline to 12.1 ± 0.2 sec at 6 h) and NS
  • Plasma aPTT was also similarly prolonged by resuscitation with LR (from 17.1 ± 0.5 sec baseline to 20.1 ± 1.2 sec at 6 h) or NS
  • NS resuscitation resulted in better oxygen delivery and oxygen delivery-to-oxygen demand ratio as an index of oxygen debt
  • NS had better tissue perfusion and oxygen metabolism than LR
  • LR resuscitation returned BE and bicarbonate to pre-hemorrhage levels within 3 h, but no return of BE or bicarbonate was observed for 6 hr with NS resuscitation
  • current blood bank guidelines state that LR should not be mixed with blood to prevent the risk of clot formation from calcium included in LR
  • LR resuscitation should not be given with blood through the same iv-line and crystalloids should be avoided in patients with blood transfusion
  • PT and aPTT were prolonged for 6 h after hemorrhage and resuscitation, suggesting a hypocoagulable states
  • potential thrombotic risk from LR resuscitation is unlikely.
  • we suspected that the blood pressure after NS resuscitation would be lower than that of LR due to its vasodilator effects
  • NS required a larger resuscitation volume and was associated with poor acid base status and elevated serum potassium in this model
  • NS required 50% more volume and was associated with a higher cardiac output and lower peripheral resistance, as compared to LR resuscitation
  • These differences are possibly due to the vasodilator effects from NS
  • an elevation of K+ was observed at 6 h post NS resuscitation, while no change of K+ was observed after LR resuscitation
  • The mechanism for the increase of K+ from NS is not fully known
  • NS is associated with vasodilator effects and the risks of metabolic acidosis and hyperkalemia
  • Nathan Goodyear on 03 Jul 18
     
    LR vs NS crystalloid.
Nathan Goodyear

Breast Cancer-Major changes in the American Joint Committee on Cancer eighth edition ca... - 0 views

onlinelibrary.wiley.com/...caac.21393

cancer breast cancer TNM staging

shared by Nathan Goodyear on 19 Jul 18 - No Cached
  • Nathan Goodyear on 19 Jul 18
     
    8th edition of AJC breast cancer staging.
Nathan Goodyear

Increasing the Effectiveness of Intravenous Vitamin C as an Anticancer Agent - ISOM - 0 views

www.isom.ca/...tamin-c-as-an-anticancer-agent

vitamin C "IV vitamin C" ozone cancer immunotherapy

shared by Nathan Goodyear on 16 May 17 - No Cached
  • Nathan Goodyear on 16 May 17
     
    Good review of ways to increase the anti-cancer efficacy of IV vitamin C.
Nathan Goodyear

Tumor markers of breast cancer: New prospectives - ScienceDirect - 0 views

www.sciencedirect.com/...S2452336416300395

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shared by Nathan Goodyear on 22 Feb 18 - No Cached
  • Nathan Goodyear on 22 Feb 18
     
    Great upto date read on breast cancer tumor markers.
Nathan Goodyear

Albumin | Professional Education - 0 views

professionaleducation.blood.ca/...albumin

albumin

shared by Nathan Goodyear on 21 Jun 18 - No Cached
  • Nathan Goodyear on 21 Jun 18
     
    albumin
Nathan Goodyear

Vitamins Against Viruses: Implausible Pro-Vaccine Publications Contrasted Against Ignor... - 0 views

isom.ca/...vitamins-against-viruses

research

shared by Nathan Goodyear on 13 Aug 19 - No Cached
  • Nathan Goodyear on 13 Aug 19
     
    I like how medical research has been presented here: post truth era.
Nathan Goodyear

High Dose IV Vitamin C and Metastatic Breast Cancer: A Case Report - ISOM - 0 views

isom.ca/...atic-breast-cancer-case-report

metastasis breast cancer High dose IV vitamin C cancer IV vitamin C vitamin C high dose vitamin C

shared by Nathan Goodyear on 09 Mar 21 - No Cached
  • Nathan Goodyear on 09 Mar 21
     
    Case study of vitamin C IV up to 75 grams IV effective in stabilizing breast cancer with mets to liver.
forestgood

Ce Uzum: A Perfect Cleansing of Blood Vessels Find out how Ce Uzum can help clear bloc... - 0 views

UZUM est un produit tres efficace ; Uzum, le complément alimentaire révolutionnaire qui nettoie efficacement les vaisseaux sanguins Les problèmes de santé cardiovasculaire sont devenus de plus en...

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started by forestgood on 05 Aug 23 no follow-up yet
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shared by erickjhonkdkk72 on 20 Jul 23 - No Cached
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indian-health

Cardiac Surgery India Your Ultimate Solution to the Secret of Your Heart Conditions - 0 views

www.apsense.com/...-of-your-heart-conditions.html

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shared by indian-health on 28 Feb 22 - No Cached
  • indian-health on 28 Feb 22
     
    Chennai is largely driven by the best cardiology hospitals in Chennai this attracts international patients as they can save as much as 70% more than in their home country.
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