Uric acid induces hepatic steatosis by generatio... [J Biol Chem. 2012] - PubMed - NCBI - 0 views
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Nathan Goodyear on 01 Oct 13Elevated uric acid levels up regulate fructose metabolism to triglycerides and fatty liver. This study finds that liver mitochondrial oxidative stress is also evident. This mitochondrial dysfunction also leads to compromised ATP production and fat accumulation specifically through inhibition of aconitase..