elevated insulin in insulin resistance decreases circulating Natriuretic peptide. This provides a direct link between obesity and cardiovascular disease
STudy finds that Testosterone reduced Thromboxane A2 production and improved the TXA2:PGI2 ratio. This is in contrast to a '95 study that finds a increase in TXA2. These men all had CHD.
BNP and NT-proBNP associated with HF and worsening HF. Also, in the same setting, elevated BNP and NT-proBNP is found to be associated with increased cardiovascular events and mortality.