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Nathan Goodyear

Re-emergence of dendritic cell vaccines for cancer treatment - 0 views

www.cell.com/...S2405-8033(17)30240-6

"Dendritic cell vaccine" dendritic cells

shared by Nathan Goodyear on 24 Oct 18 - No Cached
  • Nathan Goodyear on 24 Oct 18
     
    Great, updated review on the future of immunotherapy, here and now.
Nathan Goodyear

https://pdfs.semanticscholar.org/3f03/58787b2bfb3f9614df62f3c545e689fbccd4.pdf?_ga=2.15... - 0 views

pdfs.semanticscholar.org/...3f9614df62f3c545e689fbccd4.pdf

Picibanil dendritic cells cancer immunotherapy

shared by Nathan Goodyear on 01 Mar 19 - No Cached
hoangkimchi liked it
  • Nathan Goodyear on 01 Mar 19
     
    Picibanil augments Dendritic cell activation and signaling.
Nathan Goodyear

Clinical use of dendritic cells for cancer therapy - The Lancet Oncology - 0 views

www.thelancet.com/...fulltext

immune system dendritic cells dendritic cell vaccines cancer immunology

shared by Nathan Goodyear on 19 Jul 19 - No Cached
  • Nathan Goodyear on 19 Jul 19
     
    To be read
Nathan Goodyear

Re-emergence of Dendritic Cell Vaccines for Cancer Treatment - 0 views

www.ncbi.nlm.nih.gov/...PMC5823288

system dendritic cells cancer immunology immune dendritic cell vaccines

shared by Nathan Goodyear on 19 Jul 19 - No Cached
  • Nathan Goodyear on 19 Jul 19
     
    To be read
Nathan Goodyear

Towards superior dendritic-cell vaccines for cancer therapy - 0 views

www.nature.com/...s41551-018-0250-x

dendritic cell vaccines immune system dendritic cells immunology cancer

shared by Nathan Goodyear on 19 Jul 19 - No Cached
  • Nathan Goodyear on 19 Jul 19
     
    To be read
Nathan Goodyear

Dendritic Cell-Based Cancer Vaccines - 0 views

www.jimmunol.org/...443.long

cancer dendritic cells dendritic cell vaccines immunology immune system

shared by Nathan Goodyear on 19 Jul 19 - No Cached
  • Nathan Goodyear on 19 Jul 19
     
    To be read
Nathan Goodyear

How imiquimod licenses plasmacytoid dendritic cells to kill tumors - 0 views

www.ncbi.nlm.nih.gov/...PMC3525638

Cancer dendritic cell vaccines dendritic cells imiquimod

shared by Nathan Goodyear on 06 Aug 19 - No Cached
  • Nathan Goodyear on 06 Aug 19
     
    To be read
Nathan Goodyear

Methionine enkephalin (MENK) improved the functions of bone marrow-derived dendritic ce... - 0 views

www.ncbi.nlm.nih.gov/...PMC3579904

cancer MET-enkephalin MET-5

shared by Nathan Goodyear on 15 Aug 21 - No Cached
  • Nathan Goodyear on 15 Aug 21
     
    MET-enkephalin acts as an immunomodulator via dendritic cell and CD8 activity
Nathan Goodyear

Low-dose mistletoe lectin-I reduces melanoma growth and spread in a scid mouse xenograf... - 0 views

www.ncbi.nlm.nih.gov/...PMC2359693

cancer mistletoe dendritic cells lectins

shared by Nathan Goodyear on 16 Oct 20 - No Cached
  • Nathan Goodyear on 16 Oct 20
     
    Mistletoe Lectin 1 induced tumor regression in mouse xenograft study. Of note in this study, there was an increase in intratumoral dendrites found. In this xenograft study, it is suggested that mistletoe via Lectins 1 induced increased innate immunity in the local tumor microenvironment.
Nathan Goodyear

VEGF receptor inhibitors block the ability of metronomically dosed cyclophosphamide to ... - 0 views

www.ncbi.nlm.nih.gov/...PMC3294103

low-dose chemotherapy glioblastoma multiforme VEGF glioblastoma cancer metronomic chemotherapy

shared by Nathan Goodyear on 11 Nov 20 - No Cached
  • Nathan Goodyear on 11 Nov 20
     
    CPA administered on an intermittent, every 6-day metronomic schedule stimulates tumor recruitment of macrophages, natural killer (NK) cells, and dendritic cells with regression of large established tumors, as seen in several implanted glioma models; also of note, VEGF inhibition inhibited this effect.
Nathan Goodyear

IL-2: The First Effective Immunotherapy for Human Cancer | The Journal of Immunology - 0 views

www.jimmunol.org/...5451

cancer IL-2 Treg immune system immunology

shared by Nathan Goodyear on 17 Apr 18 - No Cached
  • IL-2 is a 15.5-kDa cytokine secreted predominately by Ag-simulated CD4+ T cells, but it can also be produced by CD8+ cells, NK cells, and activated dendritic cells
  • IL-2 is the predominant factor responsible for the maintenance of CD4+ regulatory T cells
  • A generalized capillary leak syndrome was induced by IL-2 in vivo that resulted in interstitial pulmonary infiltrates and substantial weight gain in patients
  • ...4 more annotations...
  • The side effects were transient and returned to baseline following treatment
  • Tumors do not express IL-2 receptors and thus the antitumor activity was the result of IL-2 stimulation of immune cell
  • Patients with metastatic melanoma or metastatic renal cell cancer were uniquely responsive to high-dose IL-2 administration, and except for patients with advanced non-Hodgkin’s lymphomas (35) only rare responses were seen in patients with other tumor types
  • The underlying toxicity of IL-2 results from a capillary leak that leads to fluid extravasation into visceral organs that can compromise their function
  • Nathan Goodyear on 17 Apr 18
     
    Great review of the history of IL-2 in the treatment of cancer.  IL-2 stimulates the immune system to attack cancer.  Don't reinvent the wheel; use what is already present and available.
Nathan Goodyear

Thymosin alpha 1: A comprehensive review of the literature - 0 views

www.ncbi.nlm.nih.gov/...PMC7747025

peptides cancer thymosin alpha-1 TA-1

shared by Nathan Goodyear on 15 Aug 21 - No Cached
  • Nathan Goodyear on 15 Aug 21
     
    Awesome review article on TA-1 and its broad immunomodulatory effects, i.e. increase IL-1, IFN-gamma, increase dendritic cell activity, inhibition of tumor growth…
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