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"Thomson Reuters Cortellis™, your advanced source for timely and accurate Life Sciences information. From drug discovery data to patent reports, the latest global regulatory documentation changes to submission guides, Cortellis can give you the confidence to make the best business decisions, faster."

Many newly diagnosed prostate cancers present as low Gleason score tumors that require no treatment intervention. Distinguishing the many indolent tumors from the minority of lethal ones remains a major clinical challenge. We now show that low Gleason score prostate tumors can be distinguished as indolent and aggressive subgroups on the basis of their expression of genes associated with aging and senescence. Using gene set enrichment analysis, we identified a 19-gene signature enriched in indolent prostate tumors. We then further classified this signature with a decision tree learning model to identify three genes-FGFR1, PMP22, and CDKN1A-that together accurately predicted outcome of low Gleason score tumors. Validation of this three-gene panel on independent cohorts confirmed its independent prognostic value as well as its ability to improve prognosis with currently used clinical nomograms. Furthermore, protein expression of this three-gene panel in biopsy samples distinguished Gleason 6 patients who failed surveillance over a 10-year period. We propose that this signature may be incorporated into prognostic assays for monitoring patients on active surveillance to facilitate appropriate courses of treatment.

"An accurate and colorful discription of a gout attack was elegantly written in 1683 by Dr. Thomas Sydenham who was himself a sufferer of gout: The victim goes to bed and sleeps in good health. About 2 o'clock in the morning, he is awakened by a severe pain in the great toe; more rarely in the heel, ankle or instep. This pain is like that of a dislocation, and yet the parts feel as if cold water were poured over them. Then follows chills and shiver and a little fever. The pain which at first moderate becomes more intense. With its intensity the chills and shivers increase. After a time this comes to a full height, accommodating itself to the bones and ligaments of the tarsus and metatarsus. Now it is a violent stretching and tearing of the ligaments- now it is a gnawing pain and now a pressure and tightening. So exquisite and lively meanwhile is the feeling of the part affected, that it cannot bear the weight of bedclothes nor the jar of a person walking in the room. "

"Researchers at MIT's McGovern Institute for Brain Research have developed a new mathematical model to describe how the human brain visually identifies objects. The model accurately predicts human performance on certain visual-perception tasks, which suggests that it's a good indication of what actually happens in the brain, and it could also help improve computer object-recognition systems."

A major extinction event is under way - but predicting which species will survive could be harder than we thought. That's the conclusion of one of the most accurate analyses ever of diversity in the marine animal fossil record.

According to a new study in Current Directions in Psychological Science, a journal of the Association for Psychological Science, regular gamers are fast and accurate information processors, not only during game play, but in real-life situations as well.

"When one diagnoses a cancer patient, it's important to gather as much information about that person as possible. But who would have thought an accurate diagnosis would depend on throwing some of that information away?"

A new study by MIT shows that babies can perform sophisticated analyses of how the physical world should behave. The scientists developed a computational model of infant cognition that accurately predicts infants' surprise at events that violate their conception of the physical world. The model, which simulates a type of intelligence known as pure reasoning, calculates the probability of a particular event, given what it knows about how objects behave. The close correlation between the model's predictions and the infants' actual responses to such events suggests that infants reason in a similar way, says Josh Tenenbaum, associate professor of cognitive science and computation at MIT.

ScienceDaily (July 28, 2011) - The human brain is the most complex of all organs, containing billions of neurons with their corresponding projections, all woven together in a highly complex, three-dimensional web. To date, mapping this vast network posed a practically insurmountable challenge to scientists. Now, however, a research team from the Heidelberg-based Max Planck Institute for Medical Research has developed a method for tackling the mammoth task. Using two new computer programs, KNOSSOS and RESCOP, a group of over 70 students mapped a network of more than 100 neurons -- and they did so faster and more accurately than with previous methods.

The Bolshoi simulation is the most accurate cosmological simulation of the evolution of the large-scale structure of the universe yet made ("bolshoi" is the Russian word for "great" or "grand").  The first two of a series of research papers describing Bolshoi and its implications have been accepted for publication in the Astrophysical Journal. The first data release of Bolshoi outputs, including output from Bolshoi and also the BigBolshoi or MultiDark simulation of a volume 64 times bigger than Bolshoi, has just been made publicly available to the world's astronomers and astrophysicists.

ScienceDaily (June 28, 2011) - A recent study from scientists at the Salk Institute for Biological Studies suggests that a strawberry a day (or more accurately, 37 of them) could keep not just one doctor away, but an entire fleet of them, including the neurologist, the endocrinologist, and maybe even the oncologist.

The Virtual Learning Resources Center (VLRC) has thousands of websites in its index and readily available to search. VLRC tries to always keep their 10,000+ pages as up to date as possible to ensure that students are receiving the most accurate information.

"Lunyr is an Ethereum-based decentralized crowdsourced encyclopedia which rewards users with app tokens for peer-reviewing and contributing information. We aim to be the starting point of the internet for finding reliable, accurate information. Our long-term vision is to develop a knowledge base API that developers can use to create next generation decentralized applications in Artificial Intelligence, Virtual Reality, Augmented Reality, and more."

"The same technology could potentially be used for bladder and multiple myeloma cancers, which also shed identifiable markers in urine. "Our goal is a device the size of a home pregnancy test priced around $10. Other prostate cancer tests coming to market cost up to $4,000 each. The UC Irvine team made price a key design factor of their work..The UC Irvine team developed a new type of sensor: They added nanoscale protein receptors to tiny, pencil-like viruses called phages that live only within bacteria. Double wrapping the phages with additional receptors greatly increases the capture and transmission of cancer molecule signals."

When you are going out of cash and necessitate paying off your surprising pending financial fixed cost at this situation, you should think applying with saving account payday loans. It is accurate alternative choice of pecuniary arrangement that presents speedy finances at the most toughest monetary phase during emergency time.

Developing a sound regulatory strategy, in-depth understanding of the country or region-specific regulatory requirements for specific product categories, along with accurate interpretations, implications, and applicability of such regulations, are instrumental in achieving a global outreach for medical products. Whether the product is a medical device, diagnostics, biologics, or a pharmaceutical drug, a careful consideration of the regulatory strategy early on is crucial for securing timely clearances or approvals.