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"Explore simultaneously in space and time with Time Machine Each Time Machine on this page captures a process in extreme detail over space and time, with billions of pixels of explorable resolution. Choose a time machine and zoom into the image while traveling backwards or forwards through time. Select a Time Warp and the time machine's authors will take you on a guided space-time tour with text annotations explaining what you are viewing. You can even learn how to create your own Time Machines and Warps."

"At JSTOR Labs, we get up each day with one goal: to shape the future of research and teaching, one project at a time. Working with partner publishers, libraries and labs, we aim to create tools for researchers, teachers and students that are immediately useful - and a little bit magical."

"We have sensitive body parts wired to the same area of the brain as rodents' fine-tuned whiskers. In people, "stimulating the fingers, lips or face in general could all have a similar effect," says UCI doctoral student Melissa Davis, co-author of the study, which appears in the June issue of PLoS ONE. "It's gender-neutral," adds co-author Ron Frostig, professor of neurobiology & behavior. He cautions that the research, funded by the National Institutes of Health, is a first step, albeit an important one.... "with the potential for maybe doing things before a victim even reaches the emergency room.""

"Previous research on rhesus macaques discovered that social rank influenced components of the stress response, brain, and immune system. With gene chip technology for measuring the expression of over 6,000 different genes, Tung, Gilad and colleagues at Yerkes, Emory University, and Johns Hopkins looked for the first time in primates at the effects of social rank on genetic function. Comparing 49 different female monkeys of different rank revealed significant changes in the expression of 987 genes, including 112 genes associated with immune system function. The result fits with data in monkeys where low rank and chronic stress lead to compromised immune function, and, more loosely, with human studies linking low socioeconomic status and high social stress to elevated disease risk."

UrtheCast (pronounced "EarthCast") is a company created around a unique vision: to provide the world's first ever, live HD video feed of Earth from space. Working in an exclusive relationship with world-famous Russian Aerospace giant RSC Energia, UrtheCast is building, launching, installing, and operating two cameras on the Russian module of the International Space Station. Starting in mid-2012, video data of the Earth collected by our cameras will be down-linked to ground stations around the planet and then displayed in near real time on the UrtheCast web platform or distributed directly to our exclusive partners and customers.

"Males and females differ in their biobehavioural response to stress, where males exhibit a heightened sympathetic response to stress compared with females. Specifically, Taylor et al. 1 propose that the classic "fight-or-flight" response to stress is adaptive for males, whilst females engage in a so-called "tend-and-befriend" response to stress. We propose that the Y-chromosome gene, SRY (sex-determining region on the Y chromosome), provides a genetic basis for the heightened sympathetic reactivity to stress and thus predominance of "fight-flight" response in males. Our idea is based on studies that demonstrate (i) the presence of SRY in brain regions and peripheral tissues abundant in catecholamines, (ii) the regulation of catecholamine synthesis and breakdown by SRY, and (iii) the role of SRY in voluntary movement and blood pressure in males"

Powerful and extensible JS data grid and explorer built on Backbone. Recline combines a data grid, Google Refine-style data transforms and visualizations all in lightweight javascript and html. Designed for standalone use or as a library to integrate into your own app. Recline builds on the powerful but lightweight Backbone framework making it extremely easy to extend and adapt and its modular design means you only have to take what you need.

Come work with us Interested in working with researchers from different disciplines within the Harvard, MIT and Broad community and an unique opportunity to participate in world-class research to make an impact on human health? Come work with us! We are looking for a computational biologists to handle data from a wide variety of experimental methods, focusing on next-gen sequencing technologies. Keep Reading...  SCDE is live The Stem Cell Discovery Engine (SCDE) is an integrated platform that allows users to consistently describe, share and compare cancer and tissue stem cell data. It is made up of an online database of curated experiments coupled to a customized instance of the Galaxy analysis engine with tools for gene list manipulation and molecular profile comparisons. The SCDE currently contains more than 50 stem cell-related experiments. Each has been manually curated and encoded using the ISA-Tab standard to ensure the quality of the data and its annotation. Keep Reading...  The Center for Health Bioinformatics at the Harvard School of Public Health provides consults to researchers for the management, integration and contextual analysis of biological high-throughput data. We are a member of the Center for Stem Cell Bioinformatics, the Environmental Statistics and Bioinformatics Core at the Harvard NIEHS Center for Environmental Health and the Genetics & Bioinformatics Consulting group for Harvard Catalyst and work closely with our colleagues in the Department of Biostatistics and the Program in Quantitative Genomics to act as a single point of contact for computational biology,

The Linked Data paradigm has therefore evolved from a practical research idea into a very promising candidate for addressing one of the biggest challenges in the area of intelligent information management: the exploitation of the Web as a platform for data and information integration in addition to document search. To translate this initial success into a world-scale disruptive reality, encompassing the Web 2.0 world and enterprise data alike, the following research challenges need to be addressed: improve coherence and quality of data published on the Web, ...

"Hundreds of species of bacteria call the human gut their home. This gut "microbiome" influences our physiology and health in ways that scientists are only beginning to understand. Now, a new study suggests that gut bacteria can even mess with the mind, altering brain chemistry and changing mood and behavior. In recent years, researchers have become increasingly interested in how gut bacteria might influence the brain and behavior, says John Cryan, a neuroscientist at University College Cork in Ireland. So far, most of the work has focused on how pathogenic bugs influence the brain by releasing toxins or stimulating the immune system, Cryan says. One recent study suggested that even benign bacteria can alter the brain and behavior, but until now there has been very little work in this area, Cryan says."

"There is a biological story with information. I have been repeating that in a natural environment, a stressor is information. So too much information would be too much stress, exceeding the threshold of antifragility. In medicine, we are discovering the healing powers of fasting, as the avoidance of too much hormonal rushes that come with the ingestion of food. Hormones convey information to the different parts of our system and too much of it confuses our biology. Here again, as with the story of the news received at too high a frequency, too much information becomes harmful. And in Chapter x (on ethics) I will show how too much data (particularly when sterile) causes statistics to be completely meaningless. Now let's add the psychological to this: we are not made to understand the point, so we overreact emotionally to noise. The best solution is to only look at very large changes in data or conditions, never small ones"

"I simply cannot believe that John Cook of Skeptical Science and psychologist Stephan Lewandowsky managed, in just 8 pages, to create something as magnificent as their new Debunking Handbook. It is packed not only with wonderful graphics, but also with a clear explanation of why many attempts to defeat misinformation fail, and what steps must be taken to do a better job. The core issue, of course, is one that I've written much about-too many scientists assume that that facts win out on their own, but that isn't actually true"

""Experiments with amoebae that usually live as individuals but must also join with others to form multicellular bodies to complete their life cycles showed that cooperation depends on kinship. If amoebae occur in well-mixed cosmopolitan groups, then cheaters will always be able to thrive by freeloading on their cooperative neighbors. But if groups derive from a single cell, cheaters will usually occur in all-cheater groups and will have no cooperators to exploit. A multicellular body like the human body is an incredibly cooperative thing," Queller says, "and sociobiologists have learned that really cooperative things are hard to evolve because of the potential for cheating. "It's the single-cell bottleneck that generates high relatedness among the cells that, in turn, allows them to cooperate, " he says."

"The results are indeed worthy of attention, with Prof Taylor's team finding that in an early stage clinical trial of 11 people who were put on a diet of just 600 calories As written about in Dr Ben Goldacre's latest Bad Science column, producing a pattern from experimental data to come to a conclusion can be a 'magical' experience, but medicine is an 'imperfect art'. "We all know one atom of experience isn't enough to spot a pattern." writes Goldacre, "But when you put lots of experiences together and process that data, you get new knowledge.""

William Gunn The Top 10 papers in Biological Sciences by Mendeley readership. With the Mendeley for Life Scientists webinar coming up on Thursday, I thought I would take a look at the readership stats for Biological Sciences. Biological Sciences has long been our biggest discipline, and having done my doctoral work in the Life Sciences, I knew this would be interesting. Overall, researchers in bioinformatics contributed most strongly to the most read papers, along with the older disciplines of micro- and molecular biology. Regardless of discipline, however, it's clear that the days of toiling away in isolation to thoroughly study one gene are over. Today, it's all about huge consortia and massive data. Here's what I found

A recent article in Scientific American questioned whether research on stem cell lines derived from unfertilized eggs was too tightly regulated by the federal government. Now that technology allows the creation of stem cells without fertilization, there is no question that federal laws and guidelines are overly restrictive, causing a detrimental effect on valuable scientific inquiry.

""It seems to me that our three basic needs, for food and security and love, are so mixed and mingled and entwined that we cannot straightly think of one without the others." - M.F.K. Fisher Human beings are notoriously terrible at knowing when we're no longer hungry. Instead of listening to our stomach - a very stretchy container - we rely on all sorts of external cues, from the circumference of the dinner plate to the dining habits of those around us. If the serving size is twice as large (and American serving sizes have grown 40 percent in the last 25 years), we'll still polish it off. And then we'll go have dessert."

"Bacterial signaling controlling biofilm formation and pathogenicity Opportunistic bacterial pathogens cause a variety of infectious diseases. Their ability to sense and respond to different microenvironments, particularly during the transition from a free-living to an indwelling pathogenic lifestyle, is largely dependent on a variety of adaptational strategies (Hall-Stoodley et al., 2004). Examples include phenotypic variation, biofilm formation, resistance to antibiotic treatments and virulence gene expression, suggested to be interlinked phenotypes largely dependent on bacterial signaling and changes in their transcription profiles "

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"However, anthropological datasets show enormous complexity in how and why men and women behave the ways that they do [vi]. Studies in human biology and anthropology regularly demonstrate a dynamic flexibility and complex biocultural context for all human behavior, and this is especially true for gender.... No matter how much some want it to be true, it is just not that simple; there are no clear cut and easy answers to why we do what we do, and why men and women sometimes have problems getting along. To ignore the enormous wealth of data on how men and women are similar AND different and to try to tackle this enormously complex reality via one-dimensional approaches is just poor science."