"For this study, the investigators bred mice lacking TRPV4 or administered a drug to deactivate it. In the absence of TRPV4, white cells turned on a set of genes that consume energy to produce heat, rather than storing the energy as excess fat. This "thermogenic" process normally occurs in brown or beige fat (commonly called "good fat"), which is found mostly in small animals and human infants to protect against cold.
When the TRPV4-deficient mice were put on a high-calorie diet for several weeks, they did not become obese, and their level of fat cell inflammation and insulin resistance was lowered.
"We have identified a target that, when inhibited, can activate beige adipose tissue and suppress inflammation," said Spiegelman."
"For me, the picture that emerges is one in which chronic inflammation caused by poor oral health sets the stage for more serious illness. (See my earlier post for more info about the connection between inflammation and cancer.) I think further research will probably turn up some surprising connections between oral bacteria and cancer, but we don't have to wait for additional research to begin taking oral hygiene seriously as a potential way to head off cancer and CVD."
Chiu now suspects that ALS is initiated by some still unknown agent or event. Then, as nerve cells begin to sicken and die, the nervous system tries to right itself by making microglia behave like wound-healers, secreting IGF-1 and other factors in an attempt to preserve motor neurons. "If the immune system has evolved in a way to help heal motor neurons," Chiu says.
Foods such as pomegranates, red grapes, pears, mushrooms, lentils, soybeans and green peas contain natural compounds which can activate autophagy, helping to prevent inflammation and gut diseases.
Dr Simon Archer and his team at Surrey University were particularly interested in looking at the genes that were switched on or off in our volunteers by changes in the amount that we had made them sleep.
"We found that overall there were around 500 genes that were affected," Archer explained. "Some which were going up, and some which were going down."
What they discovered is that when the volunteers cut back from seven-and-a-half to six-and-a-half hours' sleep a night, genes that are associated with processes like inflammation, immune response and response to stress became more active. The team also saw increases in the activity of genes associated with diabetes and risk of cancer. The reverse happened when the volunteers added an hour of sleep.
So the clear message from this experiment was that if you are getting less than seven hours' sleep a night and can alter your sleep habits, even just a little bit, it could make you healthier
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