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""We probably have underestimated the role our microbial flora play in modulating disease risk," says Daniel Rader, a heart disease specialist at the University of Pennsylvania School of Medicine. Rader, who was not involved in the study, says that gut bacteria may not be as big a factor in causing heart disease as diabetes or smoking, but could be important in tipping some people toward sickness. Researchers led by Stanley Hazen, a cardiologist at the Cleveland Clinic, didn't start out to study gut bacteria. In fact, says Hazen, he had "no clue - zero," that intestinal microbes were involved in heart disease. "I'd never even considered it or thought of the concept." Hazen and his colleagues compared blood plasma from healthy people to plasma from people who had had heart attacks, strokes or died to see if substances in the blood could predict who is in danger from heart disease. The researchers found 18 small molecules associated with fat buildup in the arteries. One of the best predictors turned out to be a byproduct made when gut bacteria break down a fat called choline (also known as lecithin). The more of this byproduct, called trimethylamine N-oxide or TMAO, a person or mouse has in the blood, the higher the risk of getting heart disease, the researchers found. Gut bacteria are actually middlemen in TMAO production. The microbes convert lecithin to a gas that smells like rotten fish. Then an enzyme in the liver changes the foul-smelling gas to TMAO."

"For 20 years, researchers have reported a potential link between gum disease and atherosclerotic heart disease from hardening of the arteries or stroke. "The message sent out by some in health-care professions, that heart attack and stroke are directly linked to gum disease, can distort the facts, alarm patients and perhaps shift the focus on prevention away from well-known risk factors for these diseases," said Dr. Peter Lockhart, a professor and chair of oral medicine at the Carolinas Medical Center in Charlotte, N.C. Lockhart wrote the heart group's new position statement in the journal Circulation. The statement was prepared after a three-year analysis of about 600 studies by an expert panel led by a dentist and a cardiologist."

Genomes aren't orderly and neat; they're exceedingly messy and complex, filled with "noise" from which subtle signals are difficult to filter. A disease can arise from one or two mutations, or from the cumulative action of hundreds. This means finding genome mutations responsible for diseases is both incredibly difficult and also often fruitless: The variation in individual genomes is so large that nearly every single potential disease-causing mutation typically turns out to be benign.

Genetic research permits the genetic diagnosis of susceptibilities of hereditary diseases. We know that the close members of a family may share many of their genes. By linking to a family in genetic research, scientists can study which genetic variances are shared by the family members who have the disease but not found in the rest of the family.

"Middle aged and elderly people with high levels of vitamin D could reduce their chances of developing heart disease or diabetes by 43%, according to researchers at the University of Warwick."

A chemistry professor at Harvard University is trying to shrink a medical laboratory onto a piece of paper that's the size of a fingerprint and costs about a penny.

http://www.ox.ac.uk/media/news_stories/2010/101207.html Peter Rothwell: In this new work, scientists from Oxford, Edinburgh, London and Japan used data on over 670 deaths from cancer in a range of randomised trials involving over 25,000 people. These trials compared daily use of aspirin against no aspirin and were done originally to look for any preventative effect against heart disease. The results, published in the Lancet, showed that aspirin reduced death due to any cancer by around 20% during the trials. But the benefits of aspirin only became apparent after taking the drug for 5 years or more, suggesting aspirin works by slowing or preventing the early stages of the disease so that the effect is only seen much later. After 5 years of taking aspirin, the data from patients in the trials showed that death rates were 34% less for all cancers and as much as 54% less for gastrointestinal cancers, such as oesophagus, stomach, bowel, pancreas and liver cancers.

"Leah Pyter: Well basically what we know is that patients with cancer have a higher likelihood of also developing depression at some point in their disease progression, so whether that occurred before and is predisposing them to cancer, or it's due to the tumours themselves, or other aspects of having the disease, we don't know. We were only studying right now whether the cancer itself can cause depression. Chris Smith: How could a tumour trigger depression, because a tumour can occur anywhere in the body, therefore at the remote sites in the brain, so how could it trigger changes in brain activity? Leah Pyter: Sure, well what we hypothesized was that the tumours themselves can produce cytokines which has been shown before. Chris Smith: These are inflammatory chemicals that drive the immune system? Leah Pyter: Right, exactly! And there is also a pile of research on how cytokines can access the brain specifically regions of the brain that are associated with depression and anxiety and emotional behaviours, and they can access the brain both tumourally through the blood, or neurally through the vegas nerves. "

ScienceDaily (Dec. 3, 2010) - Personalized medicine centers on being able to predict the risk of disease or response to a drug based on a person's genetic makeup. But a study by scientists at Washington University School of Medicine in St. Louis suggests that, for most common diseases, genes alone only tell part of the story.

Cancer has been one disease that has been haunting mankind since a very long time. Cancer is considered to be one of the most complex diseases that can affect any part of the body.

The dreadful disease brain cancer affects the part of the brain cell and slowly spreads to the whole part and turns to be a deadly tumor. Due to this the individual who falls as a prey to the disease will face several health issues while fighting with the destructive cell.

Common beans (Phaseolus vulgaris L.) are the most important legume staple food in Kenya coming second to maize. In Central Highlands of Kenya, the 0.4-0.5ton ha-1 output is below the genetic yield potential of 1.5-2ton ha-1 partly due pests and diseases. Plant parasitic nematodes (PPN) have been reported to cause yield losses of up to 60% on beans. Though bean production is important in the Central highlands of Kenya, information on PPN associated with the beans in the region is lacking. This study was therefore undertaken to establish the diversity of PPN associated with common beans and to assess the root knot nematode damage on beans in the region. The study covered 50 farms (32 in Kirinyaga and 18 in Embu Counties) distributed in eight localities namely Kibirigwi (L1), Makutano (L2), Kagio (L3), Mwea (L4) and Kutus (L5) in Kirinyaga County and Nembure (L6), Manyatta (L7) and Runyenjes (L8) in Embu County and covering three Agro Ecological Zones (AEZs); UM2 (L1, L2, L3 & L4), UM3 (L5, L7 & L8) and UM4 (L6) AEZs. Manyatta (L7) and Nembure (L6), had the highest and second highest gall indices, respectively, while Kibirigwi (L1), Makutano (L2) and Mwea (L4) had some of the lowest gall indices. The most common PPN in bean roots were Meloidogyne spp. Pratylenchus spp. and Scutellonema spp. with a frequency of 94.38%, 78.25% and 59.13%, respectively. This further confirm the importance of these nematodes in bean production systems. Upper Midland 3 (UM3) AEZs and UM4 had higher nematode population densities and diversity than UM2. Disease severity and nematode composition and distribution were notably low in the irrigated areas Kibirigwi, Kagio and Mwea compared to rain-fed areas such as Makutano, Nembure and Manyatta.

"Dr Zbinden said that while the discovery of the bacterium is no cause for alarm, it is important that it is recognised and the risk is quantified. "This bacterium seems to have a natural potential to cause severe disease and so it's important that clinicians and microbiologists are aware of it"

Three new genes associated with Alzheimer's have been discovered, to the delight of researchers in the field. In two papers published in Nature Genetics, two teams describe how they compared the genomes of sufferers to healthy controls to identify potential gene variations leading to the disease.

Fifteen years since the last discovery of its kind, scientists have finally identified a new set of genes that may contribute to Alzheimer's disease. The three new genes, known as clusterin, complement receptor 1 (CR1) and PICALM, were uncovered by two separate research groups.