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GENES that increase the risk of Alzheimer's and a blood protein that speeds up cognitive decline are radically changing our view of the devastating illness. Reported this week, both findings suggest new causes for Alzheimer's, boosting prospects for its treatment and prevention.

Fifteen years since the last discovery of its kind, scientists have finally identified a new set of genes that may contribute to Alzheimer's disease. The three new genes, known as clusterin, complement receptor 1 (CR1) and PICALM, were uncovered by two separate research groups.

"Individuals whose diet includes more salad dressing, nuts, fish, poultry and certain fruits and vegetables and fewer high-fat dairy products, red meats, organ meats and butter appear less likely to develop Alzheimer's disease, according to a report posted online today that will appear in the June print issue of Archives of Neurology, one of the JAMA/Archives journals."

The benefits of resveratrol. Does it really work to help prevent cancer and alzheimer's disease?

ScienceDaily (Apr. 13, 2011) - If mice commuted, their brains might find it progressively harder to navigate the maze of Los Angeles freeways. A new study reveals that after short-term exposure to vehicle pollution, mice showed significant brain damage -- including signs associated with memory loss and Alzheimer's disease.

A new new brain imaging system that can identify a subject's simple thoughts may lead to clearer diagnoses for Alzheimer's disease or schizophrenia - as well as possibly paving the way for reading people's minds. Michael Greicius at Stanford University in California and colleagues used functional magnetic resonance imaging (fMRI) to identify patterns of brain activity associated with different mental states. He asked 14 volunteers to do one of four tasks: sing songs silently to themselves; recall the events of the day; count backwards in threes; or simply relax. Participants were given a 10-minute period during which they had to do this. For the rest of that time they were free to think about whatever they liked. The participants' brains were scanned for the entire 10 minutes, and the patterns of connectivity associated with each task were teased out by computer algorithms that compared scans from several volunteers doing the same task. This differs from previous experiments, in which the subjects were required to perform mental activities at specific times and the scans were then compared with brain activity when they were at rest. Greicius reasons his method encourages "natural" brain activity more like that which occurs in normal thought.

Three new genes associated with Alzheimer's have been discovered, to the delight of researchers in the field. In two papers published in Nature Genetics, two teams describe how they compared the genomes of sufferers to healthy controls to identify potential gene variations leading to the disease.

UCLA and University of Pittsburgh researchers found that obese people had 8 percent less brain tissue than people with normal weight, while overweight people had 4 percent less tissue in their frontal lobes.

Until recently, the control of protein synthesis seemed straightforward and of little concern to most neuroscientists. However, the simple story of gene transcription into messenger RNA (mRNA) and subsequent translation into a protein has recently become considerably more complicated. Small RNA molecules have been discovered that can determine when and if the mRNA for a particular protein will be translated.