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Stubborn Belly fat can make your jeans feel extra snug, many can think how to lose belly fat, but really there is something way worse about in Health2day

"For this study, the investigators bred mice lacking TRPV4 or administered a drug to deactivate it. In the absence of TRPV4, white cells turned on a set of genes that consume energy to produce heat, rather than storing the energy as excess fat. This "thermogenic" process normally occurs in brown or beige fat (commonly called "good fat"), which is found mostly in small animals and human infants to protect against cold. When the TRPV4-deficient mice were put on a high-calorie diet for several weeks, they did not become obese, and their level of fat cell inflammation and insulin resistance was lowered. "We have identified a target that, when inhibited, can activate beige adipose tissue and suppress inflammation," said Spiegelman."

Fats in foods like potato chips and french fries make them nearly irresistible because they trigger natural marijuana-like chemicals in the body called endocannabinoids, researchers at the University of California, Irvine, have found. The researchers discovered that when rats tasted something fatty, cells in their upper gut started producing endocannabinoids, while sugars and proteins did not have this effect. How fats create, like, a buzz It starts on the tongue, where fats in food generate a signal that travels first to your brain, and then through a nerve bundle called the vagus to your intestines. There, the signal stimulates the production of endocannabinoids, which initiates a surge in cell signaling that prompts you to totally pig out - probably by initiating the release of digestive chemicals linked to hunger and satiety that compel us to eat more. And that leads to obesity, diabetes and cancer, the researchers said. But they suggest it might be possible to curb this process by obstructing endocannabinoid activity: for example, by using drugs that "clog" cannabinoid receptors. The trick: bypassing the brain to avoid creating anxiety and depression (which happens when endocannabinoid signaling is blocked in the brain). I'm guessing McDonald's won't be adding that drug to their fries. Ref.: Daniele Piomelli, et al., An endocannabinoid signal in the gut controls dietary fat intake, PNAS, 2011; in press

"Note that the antimicrobial peptides are produced largely in the fat bodies-so there would be less of this sort of response in forager bees, which don't maintain their fat bodies. This makes sense, since foragers aren't expected to live for long. However, keep in mind that the bees in protein-hungry colonies are unable to develop their fat bodies fully-this one point where nutrition ties in to immunity. Surprisingly, Jay Evans found that these genes are not upregulated in bees from CCD colonies, even though the bees are full of pathogens! There are a few potential explanations for this finding that come to mind: The bee hemocytes are not recognizing the pathogens as foreign (suppression of recognition systems, perhaps by viruses?). The colonies could be protein-starved. Something is suppressing the transcription of the genes, or their translation to peptides. Note that viruses can do this very thing, which I feel may be a big clue!"

""We probably have underestimated the role our microbial flora play in modulating disease risk," says Daniel Rader, a heart disease specialist at the University of Pennsylvania School of Medicine. Rader, who was not involved in the study, says that gut bacteria may not be as big a factor in causing heart disease as diabetes or smoking, but could be important in tipping some people toward sickness. Researchers led by Stanley Hazen, a cardiologist at the Cleveland Clinic, didn't start out to study gut bacteria. In fact, says Hazen, he had "no clue - zero," that intestinal microbes were involved in heart disease. "I'd never even considered it or thought of the concept." Hazen and his colleagues compared blood plasma from healthy people to plasma from people who had had heart attacks, strokes or died to see if substances in the blood could predict who is in danger from heart disease. The researchers found 18 small molecules associated with fat buildup in the arteries. One of the best predictors turned out to be a byproduct made when gut bacteria break down a fat called choline (also known as lecithin). The more of this byproduct, called trimethylamine N-oxide or TMAO, a person or mouse has in the blood, the higher the risk of getting heart disease, the researchers found. Gut bacteria are actually middlemen in TMAO production. The microbes convert lecithin to a gas that smells like rotten fish. Then an enzyme in the liver changes the foul-smelling gas to TMAO."

HAVING a larger waistline may shrink your brain.

" Moving Beyond Belly Button Biodiversity…we will study the species living with you on your body but also in the other biomes of YOUR household. If you want to know who is hiding in your refrigerator or mating in the pillow where you rest your head, we can help you. When you look beside you in bed, you notice no more than one animal (alternative lifestyles and cats notwithstanding). For nearly all of our history, our beds and lives were shared by multitudes. Live in a mud-walled hut in the Amazon, and bats will sleep above you, spiders beside you, the dog and cat not far away, and then there are the insects beating themselves stupid against the dwindling animal-fat flame. In addition, your gut would be filled with intestinal worms, your body (and nearly everything else) covered in multitudes of unnamed microbes, and your lungs occupied by a fungus uniquely your own."

Globs of human fat removed during liposuction conceal versatile cells that are more quickly and easily coaxed to become induced pluripotent stem cells, or iPS cells, than are the skin cells most often used by researchers, according to a new study from Stanford's School of Medicine.

What happens to fat left over from a liposuction procedure? Brad Pitt might choose to turn it in to soap, but scientists at Stanford University have figured out a surprising alternative: stem cells.

"Individuals whose diet includes more salad dressing, nuts, fish, poultry and certain fruits and vegetables and fewer high-fat dairy products, red meats, organ meats and butter appear less likely to develop Alzheimer's disease, according to a report posted online today that will appear in the June print issue of Archives of Neurology, one of the JAMA/Archives journals."

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