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A new new brain imaging system that can identify a subject's simple thoughts may lead to clearer diagnoses for Alzheimer's disease or schizophrenia - as well as possibly paving the way for reading people's minds. Michael Greicius at Stanford University in California and colleagues used functional magnetic resonance imaging (fMRI) to identify patterns of brain activity associated with different mental states. He asked 14 volunteers to do one of four tasks: sing songs silently to themselves; recall the events of the day; count backwards in threes; or simply relax. Participants were given a 10-minute period during which they had to do this. For the rest of that time they were free to think about whatever they liked. The participants' brains were scanned for the entire 10 minutes, and the patterns of connectivity associated with each task were teased out by computer algorithms that compared scans from several volunteers doing the same task. This differs from previous experiments, in which the subjects were required to perform mental activities at specific times and the scans were then compared with brain activity when they were at rest. Greicius reasons his method encourages "natural" brain activity more like that which occurs in normal thought.

Apply the electrodes... Externally modulating the brain's activity can boost its performance. The easiest way to manipulate the brain is through transcranial direct current stimulation (tDCS), which involves applying electrodes directly to the head to influence neuron activity with an electric current. Roi Cohen Kadosh's team at the University of Oxford showed last year that targeting tDCS at the brain's right parietal lobe can boost a person's arithmetic ability - the effects were still apparent six months after the tDCS session (newscientist.com/article/dn19679). More recently, Richard Chi and Allan Snyder at the University of Sydney, Australia, demonstrated that tDCS can improve a person's insight. The pair applied tDCS to volunteers' anterior frontal lobes - regions known to play a role in how we perceive the world - and found the participants were three times as likely as normal to complete a problem-solving task (newscientist.com/article/dn20080). Brain stimulation can also boost a person's learning abilities, according to Agnes Flöel's team at the University of Münster in Germany. Twenty minutes of tDCS to a part of the brain called the left perisylvian area was enough to speed up and improve language learning in a group of 19 volunteers (Journal of Cognitive Neuroscience, DOI: 10.1162/jocn.2008.20098). Using the same technique to stimulate the brain's motor cortex, meanwhile, can enhance a person's ability to learn a movement-based skill (Proceedings of the National Academy of Sciences, DOI: 10.1073/pnas.0805413106).

Vera Gorbunova and Andrei Seluanov of the University of Rochester have found that human cells undergoing oxidative stress caused by environmental chemicals or routine cellular processes produce a protein (SIRT6) that stimulates cells to repair DNA double-strand breaks, thought to be associated with premature aging and cancer. The team first measured levels of SIRT6 in stressed cells, then treated a second group of stressed cells with a drug that deactivates the protein. DNA repair in the second group stopped, confirming SIRT6′s role.  The team also found that SIRT6 acts in concert with another protein, called PARP1, to make the repairs. Furthermore, the team found that increased levels of SIRT6 lead to faster DNA repair. They suspect that the protein acts as a "master regulator," coordinating stress and DNA repair activities. Ref.: Zhiyong Mao, Christopher Hine, Xiao Tian, Michael Van Meter, Matthew Au, Amita Vaidya, Andrei Seluanov, and Vera Gorbunova. SIRT6 Promotes DNA Repair Under Stress by Activating PARP1. Science 17 June 2011: 1443-1446. [DOI:10.1126/science.1202723]

Speculative connections between electric lighting, sleep deficits, and health.

I wonder if the driving force behind the sleep deficit is in fact more pervasive, and indeed global in nature: the triumph of light.

A technique for creating a new molecule that structurally and chemically replicates the active part of the widely used industrial catalyst molybdenite has been developed by researchers with the U.S.

Free Download - StanfordUniversity - January 22, 2009 - Karl Deisseroth is pioneering bold new treatments for depression and other psychiatric diseases. By sending pulses of light into the brain, Deisseroth can control neural activity with remarkable precision. In this short talk, Deisseroth gives an thoughtful and awe-inspiring overview of his Stanford University lab's groundbreaking research in "optogenetics".

WikiLeaks is again publishing a trove of documents, in this case classified U.S. State Department diplomatic cables. The whistle-blower website will gradually be releasing more than 250,000 of these documents in the coming months so that they can be analyzed and gain the attention they deserve. The cables are internal, written communications among U.S. embassies around the world and also to the U.S. State Department. WikiLeaks described the leak as "the largest set of confidential documents ever to be released into the public domain [giving] an unprecedented insight into U.S. government foreign activities."

To know what the most important virtue of our age is we need to have at least a basic understanding of our age. Our era is becoming increasingly characterized by uncertainty. Fortunately or unfortunately, more than a cursory elucidation of our situation is beyond the scope of this essay. There are geopolitical, economic, technological and environmental trends worth mentioning. When the more philosophical portion of this  discourse arrives I will argue that the virtue of wisdom underlies the meaningfulness and efficacy of all other virtues, and this in broad strokes is primarily due to (1) the aforementioned instability in our surroundings ; (2) the relationship between the deontological and virtue; and (3) the nature of agency itself.  Whether uncertainty itself can provide an ethical foundation for us to elaborate on will be a separate question, and finally I speculate on where wisdom leads us in the context of a philosophy that is politically active and not doomed to irrelevance to and by the larger population.

The new device would also allow "power proportional computing." For example, Web server farms, such as those used by Google, consume an enormous amount of power - even when there are low levels of user activity - in part because the server farms can't turn off the power without affecting their main memory.

"In nineteenth‐century America, there was no such person as a "professional scientist." There were professionals and there were scientists, but they were very different. Professionals were men of science who engaged in commercial relations with private enterprises and took fees for their services. Scientists were men of science who rejected such commercial work and feared the corrupting influences of cash and capitalism. Professionals portrayed themselves as active and useful members of an entrepreneurial polity, while scientists styled themselves as crusading reformers, promoters of a purer science and a more research‐oriented university. It was this new ideology, embodied in these new institutions, that spurred these reformers to adopt a special name for themselves-"scientists." One object of this essay, then, is to explain the peculiar Gilded Age, American origins of that ubiquitous term. A larger goal is to explore the different social roles of the professional and the scientist. By attending to the particular vocabulary employed at the time, this essay tries to make clear why a "professional scientist" would have been a contradiction in terms for both the professional and the scientist in nineteenth‐century America. "

The important debate on global warming under UN auspices provides but a partial picture of climate change; in addition to the devastating impacts of greenhouse gas emissions on the ozone layer, the World's climate can now be modified as part of a new generation of sophisticated "non-lethal weapons." Both the Americans and the Russians have developed capabilities to manipulate the World's climate. In the US, the technology is being perfected under the High-frequency Active Aural Research Program (HAARP) as part of the ("Star Wars") Strategic Defence Initiative (SDI). Recent scientific evidence suggests that HAARP is fully operational and has the ability of potentially triggering floods, droughts, hurricanes and earthquakes.

"And what if science becomes - or has become - lower-yield? Is that a reason to reconsider funding policies? Rationally, looking at the cost-benefit may already have effects on resource and funding allocations. Is it unreasonable to assume that science will continue to produce large, demonstrable advances and insights of the size and importance of the major breakthroughs?"

I think the comments under the linked article sufficiently refute it.

Social media present risks and benefits to children but parents who try to secretly monitor their kids' activities online are wasting their time, says Larry D. Rosen, Ph.D., professor of psychology at California State University, Dominguez Hills. Rosen identifies potential adverse effects of social media, including: Teens who use Facebook more often show more narcissistic tendencies, while young adults who have a strong Facebook presence show more signs of other psychological disorders, including antisocial behaviors, mania, and aggressive tendencies. Daily overuse of media and technology has a negative effect on the health of all children, especially preteens and teenagers, by making them more prone to anxiety, depression, and other psychological disorders, and making them more susceptible to future health problems. Facebook can be distracting and can negatively impact learning. Studies found that middle school, high school and college students who checked Facebook at least once during a 15-minute study period achieved lower grades. Rosen says new research has also found positive influences linked to social networking, including: Young adults who spend more time on Facebook are better at showing "virtual empathy" to their online friends. Online social networking can help introverted adolescents learn how to socialize. Social networking can provide tools for teaching in compelling ways that engage young students. "If you feel that you have to use some sort of computer program to surreptitiously monitor your child's social networking, you are wasting your time. Your child will find a workaround in a matter of minutes," he says. "You have to start talking about appropriate technology use early and often and build trust, so that when there is a problem, whether it is being bullied or seeing a disturbing image, your child will talk to you about it." Ref.: Larry D. Rosen, Poke Me: How Social Networks Can Both Help and Harm Our Kids, 2011; 119th Annua

With its expansive range and unprecedented potential for anonymity, (the Internet gives voice to our deepest urges and most uninhibited thoughts. Inspired by the wealth of unfettered expression available online, neuroscientists Ogi Ogas and Sai Gaddam, who met as Ph.D. candidates at Boston University, began plumbing a few chosen search engines (including Dogpile and AOL) to create the world's largest experiment in sexuality in 2009. Quietly tapping into a billion Web searches, they explored the private activities of more than 100 million men and women around the world. The result is the first large-scale scientific examination of human sexuality in more than half a century, since biologist Alfred Kinsey famously interviewed more than 18,000 middle-class Caucasians about their sexual behavior and published the Kinsey reports in 1948 and 1953. Building on the work of Kinsey, neuroscientists have long made the case that male and female sexuality exist on different planes. But like Kinsey himself, they have been hampered by the dubious reliability of self-reports of sexual behavior and preferences as well as by small sample sizes. That is where the Internet comes in. By accessing raw data from Web searches and employing the help of Alexa-a company that measures Web traffic and publishes a list of the million most popular sites in the world-Ogas and Gaddam shine a light on hidden desire, a quirky realm of lust, fetish, and kink that, like the far side of the moon, has barely been glimpsed. Here is a sampling of their fascinating results, selected from their book, A Billion Wicked Thoughts.

About the High Frequency Active Auroral Research Program.

More than 50 severely disabled people in Second Life have been trying out a sophisticated new brain-computer interface (BCI) that lets users freely explore Second Life's virtual world and control their real-world environment. The system was developed by medical engineering company G.Tec of Schiedlberg, Austria as part of a pan-European project called Smart Homes for All. It's the first time the latest BCI technology has been combined with smart-home technology and online gaming. To activate a command, the user focuses their attention on the corresponding icon on a screen. Electroencephalograph (EEG) caps pick up brain signals, which are translated into commands to navigate and communicate within Second Life and Twitter. It can also be used to open and close doors, answer the phone, and control the TV, lights, thermostat, and intercom. G.Tec's system has been tested at the Santa Lucia Foundation Hospital in Rome, Italy.

Microsoft has posted an awesome new concept video with some ubercool new interfaces that could be here in five to ten years, estimates Kurt DelBene, President, Microsoft Office Division. That sounds a bit conservative. "All of the ideas in the video are based on real technology," he said. "Some of the capabilities, such as speech recognition, real time collaboration, and data visualization, already exist today. Others are not yet available in specific products, but represent active research and development happening at Microsoft and other companies." "Other companies" … hmm, some of the concepts look a bit like Nokia's visionary Morph concept tech  (see the video at the bottom of this post and our 2010 news item).

From proof-of-concept to post-marketing surveillance services, you can depend on our PV experts to efficiently work through the entire scope of Pharmacovigilance activities. We offer a high level of expertise and assist in meeting the highest standards of applicable national and global regulations. The experts at ACL Digital can easily customize safety monitoring services to suit your specific business requirements. Most biopharmaceutical companies have distinct and demanding clinical safety requirements as per the directions of regulatory agencies. You can depend on our PV specialists who plan safety and pharmacovigilance services accordingly that fit the needs of both your product and study - we adhere and adapt to your processes and are flexible enough to do it the right way.