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chanon chiarnpattanodom

Genes an Important Factor in Urinary Incontinence - 1 views

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    Scientists have studied how much is urinary incontinence controlled by genetics, rather than the environment by observing twins. 
Kantham Hongdusit

Niceness, Generosity May Have A Genetic Component - 0 views

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    Psychologists from the Buffalo University and University of California have conducted a survey to find out if DNA can affect how a person perceives the world. They conclude that there is a specific gene, which has not yet been identified, that controls the receptors of oxytocin and vasopressin, hormones that display "niceness".
nidthamsirisup

Stem Cell Treatment Spurs Cartilage Growth - Science News - 0 views

  • A small molecule dubbed kartogenin encourages stem cells to take on the characteristics of cells that make cartilage, a new study shows
  • And treatment with kartogenin allowed many mice with arthritis-like cartilage damage in a knee to regain the ability to use the joint without pain.
  • Kartogenin steers the stem cells to wake up and take on cartilage-making duties. This is an essential step in the cartilage repair that falls behind in people with osteoarthritis, the most common kind of arthritis, which develops from injury or long-term joint use.
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  • The molecule turned on genes that make cartilage components called aggrecan and type II collagen. Tests of mice with cartilage damage similar to osteoarthritis showed that kartogenin injections lowered levels of a protein called cartilage oligomeric matrix protein. People with osteoarthritis have an excess of the protein, which is considered a marker of disease severity.
  • kartogenin inhibits a protein called filamin A in the mesenchymal stem cells
chanon chiarnpattanodom

A new class of obesity genes encodes leukocyte adhesion receptors - 0 views

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    Obesity is controlled by a number of factors, mainly 2 factors genetics and the environment. Here they use 2 groups + 1 control group mice to compare obesity.
Paige Prescott

Human Genome Project Science - 7 views

  • The human genome contains 3164.7 million chemical nucleotide bases (A, C, T, and G).
  • The average gene consists of 3000 bases, but sizes vary greatly, with the largest known human gene being dystrophin at 2.4 million bases.
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    check out when the last time this page was updated.  What information has changed in the last 4 years?
Paige Prescott

DNA The Code of Life | The Language of Life | deCODEme - 4 views

  • Genes are especially important segments of DNA that directly influence one or more traits. They are relatively small segments of chromosomes, where the sequence of DNA nucleotides encodes a recipe for making a protein. Small differences in the sequence of DNA nucleotides of a particular gene can lead to differences in the structure and behavior of the proteins they encode. It is these differences, in turn, that account for the variable characteristics of the people around you.
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    deCodeMe is a private company that sells DNA technology
Pop karnchanapimonkul

Study Identifies Genetic Regulators Hijacked By Avian And Swine Flu Viruses - 0 views

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    Genes and Swine Flu
Kaoko Miyazaki

Long Intergenic Noncoding RNAs: New Links in Cancer Progression - 1 views

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    The newly discovered and currently being researched lincRNAs are seen to be one of the causes of cancer. The function of lincRNAs to control gene expression by regulating the number of histones according to specific chromatin, may cause cancer when done wrong or are altered in some way. The epigenetic alterations that occur when this function is done wrong may lead to the disease and the inheritance of it. Which could be hypothesized as to why people with a history of cancer (and other diseases) within their families have higher likelihood to being diagnosed with the disease. But because lincRNA is a very recent discovery and only less than 1% of it has has been characterized in the human body, evidence of this is still being researched, tested and studied.
orasa sukmark

Shot of Young Stem Cells Makes Rapidly Aging Mice Live Much Longer and Healthier - Gate... - 1 views

  • animals that got the stem/progenitor cells improved their health and lived two to three times longer than expected,
  • "Our experiments showed that mice that have progeria, a disorder of premature aging, were healthier and lived longer after an injection of stem cells from young, healthy animals," Dr. Niedernhofer said. "That tells us that stem cell dysfunction is a cause of the changes we see with aging."
  • "Typically the progeria mice die at around 21 to 28 days of age, but the treated animals lived far longer -- some even lived beyond 66 days. They also were in better general health."
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  • we injected stem/progenitor cells from young, healthy mice into the abdomens of 17-day-old progeria mice,
  • As the progeria mice age, they lose muscle mass in their hind limbs, hunch over, tremble, and move slowly and awkwardly. Affected mice that got a shot of stem cells just before showing the first signs of aging were more like normal mice, and they grew almost as large.
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    the experiment from the University of Pittsburgh shows that the mice can be stronger live longer after they were injected with stem cells from young healthy animals.
Nickyz P.

We Need More Research On Genetically Altered Salmon Says FDA Advisory Panel - 1 views

  • A panel of experts that advises the US Food and Drug Administration (FDA) decided on Monday more research was needed before it could vote on whether to recommend approval to allow genetically modified salmon to be bred for human consumption in the US.
  • To make the genetically modified Atlantic salmon, they take the growth gene from the Pacific chinook salmon and insert it into the DNA of newly fertilized Atlantic salmon eggs. However, this of itself is not enough to keep the salmon growing all year round: to keep the growth gene permanently "switched on", the AquaBounty scientists also add a small piece of DNA from another fish called the ocean pout.
Changul Louis Yeum

Study Says DNA's Power to Predict Illness Is Limited - 0 views

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    The answer, according to a new study of twins, is, for the most part, "no." While sequencing the entire DNA of individuals is proving fantastically useful in understanding diseases and finding new treatments, it is not a method that will, for the most part, predict a person's medical future.
Paige Prescott

Old Cancer Drugs Offer New Tricks - Science News - 0 views

  • Drugs that alter some chemical tags on DNA make cancer cells behave more like normal cells
  • And the drugs seem to make cancer cells more susceptible to chemotherapy and attacks from the immune system.
  • drugs called azacitidine and decitabine, when used in low doses, change gene activity in leukemia and breast cancer cells in the lab. If DNA is a cell’s hard drive, then chemical tags attached to the DNA or DNA-packaging proteins called histones serve as software packages to tell the hard drive how to function. This type of chemical programming is called epigenetics.
Nitchakan Chaiprukmalakan

Biotechdaily - Low MicroRNA Activity Characterizes Inflamed Lung Tissues - 0 views

  • A recent study examined the interaction between a specific microRNA (miRNA) and the activity of the inflammatory cytokine interleukin 13 (IL-13).
  • In the current study, investigators at the Cincinnati Children's Hospital Medical Center (Ohio, USA) examined the effect that stimulation of IL-13 activity has on microRNAs, particularly miR-375
  • They reported in the March 28, 2012, online edition of the journal Mucosal Immunology that IL-13 induced changes in epithelial gene and protein expression including the consistent downregulation of miR-375 in IL-13 stimulated human esophageal squamous and bronchial epithelial cells.
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  • Analysis of miR-375 levels in a human disease characterized by IL-13 overproduction - the allergic disorder eosinophilic esophagitis (EE) - revealed downregulation of miR-375 in EE patient samples compared with control patients. Low levels of miR-375 expression levels indicated disease activity.
  • “MiR-375 is proof of principle that microRNAs are involved in fine-tuning IL-13-mediated responses, which opens up a set of new possibilities for novel therapeutic targets for treatment of allergic disease.”
  • “The identification of a microRNA that regulates IL-13-induced changes and inflammatory pathways is a significant advancement for the understanding and future treatment of allergic disease,
Oranicha Jumreornvong

EBSCOhost: The orchid children - 0 views

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    Features Are you an orchid or a dandelion? Are you a sensitive flower or a hardier type? It may all be down to an intriguing set of genes, as David Dobbs finds out WHY are some children better at sharing than others? One attempt to find out uses what you could call the "Bamba test".
Oranicha Jumreornvong

EBSCOhost: What Makes Each Brain Unique - 0 views

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    NEUROSCIENCE How can identical twins grow up with different personalities? "Jumping genes" move around in neurons and alter the way they work YOUR BRAIN IS SPECIAL. So is mine. Differences arise at every level of the organ's astonishingly intricate architecture; the human brain contains 100 billion neurons, which come in thousands of types and collectively form an estimate of more than 100 trillion interconnections.
Nitchakan Chaiprukmalakan

Biotechdaily - Human Mitochondrial Mutations Repaired by New Technique - 2 views

  • researchers have identified a generic approach to correct mutations in human mitochondrial DNA by targeting corrective RNAs,
  • In adults, many aging disorders have been associated with defects of mitochondrial function, including diabetes, Parkinson’s disease, cancer, heart disease, stroke, and Alzheimer’s disease.
  • The introduction of nucleus-encoded small RNAs into mitochondria is critical for the replication, transcription, and translation of the mitochondrial genome,
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  • The study defined a new role for a protein called polynucleotide phosphorylase (PNPASE) in regulating the import of RNA into mitochondria. Reducing the expression--or output--of PNPASE decreased RNA import, which impaired the processing of mitochondrial genome-encoded RNAs. Reduced RNA processing inhibited the translation of proteins required to maintain the mitochondrial electron transport chain that consumes oxygen during cell respiration to produce energy. With reduced PNPASE, unprocessed mitochondrial-encoded RNAs accumulated, protein translation was inhibited, and energy production was compromised, leading to stalled cell growth.
  • Geng Wang developed a strategy to target and import specific RNA molecules encoded in the nucleus into the mitochondria and, once there, to express proteins needed to repair mitochondrial gene mutations.
  • First, the researchers had to find a way to stabilize the reparative RNA so that it was moved out of the nucleus and then localized to the mitochondrial outer membrane. This was accomplished by modifying an export sequence to direct the RNA to the mitochondrion. Once the RNA was in the area of the transport machinery on the mitochondrial surface, then a second transport sequence was required to direct the RNA into the targeted organelle. With these two modifications, a wide range of RNAs were targeted to and imported into the mitochondria, where they worked to repair defects in mitochondrial respiration and energy production in two different cell line models of human mitochondrial disease.
    • Nitchakan Chaiprukmalakan
       
      This article shows the importance of the RNAs in making proteins for the mitochondria to work efficiently.  The article summarizes a method in repairing the mitochondria that is still being worked on.
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    Mutations in the mitochondrial genome inflicts diseases
adisa narula

The Top 10 Everything of 2009 - TIME - 1 views

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    The decoding of the human genome nearly a decade ago fueled expectations that an understanding of all human hereditary influences was within sight. But the connections between genes and, say, disease turned out to be far more complicated than imagined.
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