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"The main problem with the drug war is the concept that there are good drugs and bad drugs," when what's actually good or bad "is the relationship between the person and the drug, and the context in which the drug is taken."

Everything we do is for the purpose of altering consciousness. We form friendships so that we can feel certain emotions, like love, and avoid others, like loneliness. We eat specific foods to enjoy their fleeting presence on our tongues. We read for the pleasure of thinking another person's thoughts. Every waking moment-and even in our dreams-we struggle to direct the flow of sensation, emotion, and cognition toward states of consciousness that we value.Drugs are another means toward this end. Some are illegal; some are stigmatized; some are dangerous-though, perversely, these sets only partially intersect. There are drugs of extraordinary power and utility, like psilocybin (the active compound in "magic mushrooms") and lysergic acid diethylamide (LSD), which pose no apparent risk of addiction and are physically well-tolerated, and yet one can still be sent to prison for their use-while drugs like tobacco and alcohol, which have ruined countless lives, are enjoyed ad libitum in almost every society on earth. There are other points on this continuum-3,4-methylenedioxymethamphetamine (MDMA or "Ecstasy") has remarkable therapeutic potential, but it is also susceptible to abuse, and it appears to be neurotoxic.[1]One of the great responsibilities we have as a society is to educate ourselves, along with the next generation, about which substances are worth ingesting, and for what purpose, and which are not. The problem, however, is that we refer to all biologically active compounds by a single term-"drugs"-and this makes it nearly impossible to have an intelligent discussion about the psychological, medical, ethical, and legal issues surrounding their use. The poverty of our language has been only slightly eased by the introduction of terms like "psychedelics" to differentiate certain visionary compounds, which can produce extraordinary states of ecstasy and insight, from "narcotics" and other classic agents of stupefaction and abuse.

The human body…It has amazing powers to fight disease of injury. Sometimes it needs a little help in the form of drugs, but today it seems that even the most powerful drugs of the future will come from the body itself - they will be derived from proteins.

I'm having a hard time thinking this is a good idea. I'd prefer to move toward less reliance on drugs rather than more.

"In this article, we propose actions that will help society accept the benefits of enhancement, given appropriate research and evolved regulation. Prescription drugs are regulated as such not for their enhancing properties but primarily for considerations of safety and potential abuse. Still, cognitive enhancement has much to offer individuals and society, and a proper societal response will involve making enhancements available while managing their risks."

ScienceDaily (Jan. 12, 2011) - Scientists have found that the pleasurable experience of listening to music releases dopamine, a neurotransmitter in the brain important for more tangible pleasures associated with rewards such as food, drugs and sex. The new study from The Montreal Neurological Institute and Hospital -- The Neuro at McGill University also reveals that even the anticipation of pleasurable music induces dopamine release [as is the case with food, drug, and sex cues]. Published in the journal Nature Neuroscience, the results suggest why music, which has no obvious survival value, is so significant across human society.

A new study suggests that a single dose of psilocybin -- the active ingredient in "Magic Mushrooms" -- can result in improved personality traits over the long term. Researchers at the Johns Hopkins University School of Medicine found that individuals who received the drug once in a clinical setting reported a greater sense of "openness" that often lasted 14 months or longer, according to study published this week in the Journal of Psychopharmacology. The study defined openness as a personality trait that "encompasses aesthetic appreciation and sensitivity, imagination and fantasy, and broad-minded tolerance of others' viewpoints and values." It is one of five main personality traits that are shared among all cultures worldwide. Of the 51 participants, 30 had personality changes that left them feeling more open. Other personality traits (extroversion, neuroticism, agreeableness and conscientiousness) were not impacted. Only the participants who said they had a "complete mystical experience" while on the drug registered an increased sense of openness. "The mystical experience has certain qualities," lead author Katherine MacLean said. "The primary one is that you feel a certain kind of connectedness and unity with everything and everyone." Because personality traits are generally considered to remain stable throughout a persons lifetime, researchers are excited about therapeutic implications of the study. "[T]his study shows that psilocybin actually changes one domain of personality that is strongly related to traits such as imagination, feeling, abstract ideas and aesthetics, and is considered a core construct underlying creativity in general," study author Roland R. Griffiths told USA Today. "And the changes we see appear to be long-term."     

Fats in foods like potato chips and french fries make them nearly irresistible because they trigger natural marijuana-like chemicals in the body called endocannabinoids, researchers at the University of California, Irvine, have found. The researchers discovered that when rats tasted something fatty, cells in their upper gut started producing endocannabinoids, while sugars and proteins did not have this effect. How fats create, like, a buzz It starts on the tongue, where fats in food generate a signal that travels first to your brain, and then through a nerve bundle called the vagus to your intestines. There, the signal stimulates the production of endocannabinoids, which initiates a surge in cell signaling that prompts you to totally pig out - probably by initiating the release of digestive chemicals linked to hunger and satiety that compel us to eat more. And that leads to obesity, diabetes and cancer, the researchers said. But they suggest it might be possible to curb this process by obstructing endocannabinoid activity: for example, by using drugs that "clog" cannabinoid receptors. The trick: bypassing the brain to avoid creating anxiety and depression (which happens when endocannabinoid signaling is blocked in the brain). I'm guessing McDonald's won't be adding that drug to their fries. Ref.: Daniele Piomelli, et al., An endocannabinoid signal in the gut controls dietary fat intake, PNAS, 2011; in press

Research suggests that psychedelics may be better than antidepressants, which tend to dampen or suppress psychological problems without necessarily curing them.

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Ginkgo biloba, piracetam, and vinpocetine are some popular cognitive enhancers, all with varying mechanisms of action in the human brain

science daily report on durham university study into relationship between caffeine intake and proneness to hallucinations