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Dennis OConnor

COVID-19 Racial Health Disparities Stress Patient Trust Pitfalls - 0 views

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    Recommended by DeAunne Denmark MD Phd. "New data showed black patients have less trust in COVID-19 mitigation, underscoring decades of racial health disparities and limited patient trust."
Dennis OConnor

The epic battle against coronavirus misinformation and conspiracy theories - 0 views

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    Recommended by Tyler Orion: "For researchers who track how information spreads, COVID-19 is an experimental subject like no other. "This is an opportunity to see how the whole world pays attention to a topic," says Renée diResta at the Stanford Internet Observatory in California. She and many others have been scrambling to track and analyse the disparate falsehoods floating around - both 'misinformation', which is wrong but not deliberately misleading, and 'disinformation', which refers to organized falsehoods that are intended to deceive. "
Dennis OConnor

Vicky A. Newman Memorial (Full) March 15, 2020 - YouTube - 0 views

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    "Vicky Newman's memorial was held in the midst of the coronavirus epidemic on 03-15-1986"
Dennis OConnor

The CDC and States Are Misreporting COVID-19 Test Data - The Atlantic - 0 views

  • A negative test result means something different for each test. If somebody tests negative on a viral test, a doctor can be relatively confident that they are not sick right now; if somebody tests negative on an antibody test, they have probably never been infected with or exposed to the coronavirus. (Or they may have been given a false result—antibody tests are notoriously less accurate on an individual level than viral tests.) The problem is that the CDC is clumping negative results from both tests together in its public reporting.
  • Mixing the two tests makes it much harder to understand the meaning of positive tests, and it clouds important information about the U.S. response to the pandemic, Jha said. “The viral testing is to understand how many people are getting infected, while antibody testing is like looking in the rearview mirror. The two tests are totally different signals,” he told us. By combining the two types of results, the CDC has made them both “uninterpretable,” he said.
  • “Combining a test that is designed to detect current infection with a test that detects infection at some point in the past is just really confusing and muddies the water,” Hanage told us.
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    "The government's disease-fighting agency is conflating viral and antibody tests, compromising a few crucial metrics that governors depend on to reopen their economies. Pennsylvania, Georgia, Texas, and other states are doing the same."
Dennis OConnor

Coronavirus Hub: Cell Press - 0 views

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    Recommended by DeAunne Denmark MD Phd, "At Cell Press, we recognize the urgent need to quickly share information about SARS-CoV-2, the coronavirus that causes COVID-19. On this hub page, curated by members of our editorial team, you'll find the latest content about the outbreak as it appears in Cell Press journals."
Dennis OConnor

Mimi Guarneri MD on Covid-19 and Vitamins D and C, Antibody Testing, potential spike on... - 0 views

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    Published May 20, 2020 - Perspective and advice from Mimi Guarneri. Vitamin C and D, right foods, good sleep, time in the sun, all help strengthen the soil. Her explanation of the "Pearl" metaphor resonates.
Dennis OConnor

The Rogue Experimenters | The New Yorker - 0 views

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    Recommended by Megan Sweeney I listened to the article. It gave me a sense of context for self-study. I also found a strong path of hope that this kind of science will grow during the disruption caused by Covid-19
Dennis OConnor

GA4GH (Global Alliance for Genomics & Health) Community Response to COVID-19 - 0 views

  • A Message from the GA4GH Executive Committee Ewan Birney, Heidi Rehm, Peter Goodhand, and Kathryn North The urgency of scientific data sharing is never more apparent than during a global disease outbreak. Rapid sharing of high quality data is critical for the effective and timely response to any pandemic. GA4GH has joined Wellcome and others to call for rapid, open sharing of research findings and data relevant to COVID-19. The GA4GH community is responding through the development of a variety of research and data sharing platforms and initiatives…. But in order to ensure truly equitable access to and participation in both the scientific process and its benefits, we must rigorously maintain technical and ethical standards that support the open sharing of data and knowledge—now and always.
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    Recommended by DeAunne Denmark, MD. Phd.
Dennis OConnor

about - COVID HUMAN GENETIC EFFORT - 0 views

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    Recommended by DeAunne Denmark, MD. Phd. : Summary of Our Work For many years, up to 25 years for some, members of the COVID Human Genetic Effort have studied the human genetic basis of life-threatening diseases striking previously healthy human beings in the course of primary infection by a variety of viruses, bacteria, fungi, or parasites. In particular, we and others have identified monogenic inborn errors of immunity (IEI) that selectively underlie life-threatening or lethal viral diseases in previously healthy children or adults, including various severe diseases caused by Epstein-Barr virus, herpes simplex virus encephalitis, varicella zoster virus encephalitis, fulminant hepatitis due to hepatitis A virus, lethal primary infection by cytomegalovirus, severe pneumonitis due to influenza virus or rhinovirus, beta-papillomavirus-driven skin cancer, human herpes virus 8-driven Kaposi sarcoma, and others (see references below).
Dennis OConnor

Recommended Twitter Feeds for Expert Advice on Science and Medicine - 1 views

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    Recommended by DeAunne Denmark, MD, PhD & Meg Sweeney
Dennis OConnor

A global effort to define the human genetics of protective immunity to SARS-CoV-2 infec... - 0 views

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    Recommended by Meg Sweeney: "Abstract SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease. The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers - individuals remaining uninfected despite viral exposure and healthy young patients with life-threatening disease - presents a unique opportunity to reveal human genetic determinants of infection and disease."
Dennis OConnor

How COVID-19 Is Shaping the Patient Experience (PDF) - 0 views

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    Recommended by Meg Sweeney © 2020 Press Ganey Associates LLCIn a Press Ganey analysis of 350,000 comments from ED and medical practice patients between January 1 and March 20, 2020, the number of comments mentioning COVID-19 has grown at an average rate of 134% each week from early February through mid-March.To identify emerging themes and provide insights and recommendations to provider organizations, we isolated and analyzed the nearly 12,000 COVID-19-related comments, generating approximately 27,000 insights and leading to the following observations
Dennis OConnor

IT'S TIME TO BUILD | a16z Podcast by Marc Andreessen - 0 views

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    Recommended by Dr. Michael Kurisu D.O.
Dennis OConnor

The Great Realisation - YouTube - 0 views

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    Suggested by Ozzie Gontang, "A bed time story of how it started, and why hindsight's 2020."
Dennis OConnor

The Risks - Know Them - Avoid Them by Erin Bromage - 0 views

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    Recommended by Tyler Orion, "It seems many people are breathing some relief, and I'm not sure why. An epidemic curve has a relatively predictable upslope and once the peak is reached, the back slope can also be predicted. We have robust data from the outbreaks in China and Italy, that shows the backside of the mortality curve declines slowly, with deaths persisting for months. Assuming we have just crested in deaths at 70k, it is possible that we lose another 70,000 people over the next 6 weeks as we come off that peak. That's what's going to happen with a lockdown. "
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    Erin Bromage: I am a Comparative Immunologist and Professor of Biology (specializing in Immunology) at the University of Massachusetts Dartmouth. I balance Teaching, Research, and Public Service (that is, when we are allowed in our labs)."
Dennis OConnor

Coronavirus and Its Impact on US Healthcare Providers (PDF) - 0 views

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    Discovered by DeAunne Denmark, MD. Phd, with the statement "It isn't clear to me how this information was collected." A new survey conducted by Public Opinion Strategies in partnership with Jarrard Phillips Cate & Hancock examines some of the critical questions facing America's health care delivery system... (including) What will be required to ensure Americans are once again comfortable and safe in a hospital or health care setting? The Executive Summary of the online survey of 1,000 adults was conducted nationally on April 16-20, 2020.
Dennis OConnor

Which Covid-19 Data Can You Trust? - 0 views

  • incomplete or incorrect data can also muddy the waters, obscuring important nuances within communities, ignoring important factors such as socioeconomic realities, and creating false senses of panic or safety, not to mention other harms such as needlessly exposing private information.
  • Right now, bad data could produce serious missteps with consequences for millions.
  • Whether you’re a CEO, a consultant, a policymaker, or just someone who is trying to make sense of what’s going on, it’s essential to be able to sort the good data from the misleading — or even misguided.
  • ...24 more annotations...
  • These non-transparent, un-validated interventions — which are now being rolled out (or rolled back) in countries such as China, India, Israel and Vietnam — are in direct contravention to the open cross-border collaboration that scientists have adopted to address the Covid-19 pandemic.
  • Data products that are too broad, too specific, or lack context.
  • Public health practitioners and data privacy experts rely on proportionality
  • only use the data that you absolutely need for the intended purpose and no more.
  • Even data at an appropriate spatial resolution must be interpreted with caution — context is key.
  • Simply presenting them, or interpreting them without a proper contextual understanding, could inadvertently lead to imposing or relaxing restrictions on lives and livelihoods, based on incomplete information.
  • The technologies behind the data are unvetted or have limited utility.
  • Both producers and consumers of outputs from these apps must understand where these can fall short.
  • In the absence of a tightly coupled testing and treatment plan, however, these apps risk either providing false reassurance to communities where infectious but asymptomatic individuals can continue to spread disease, or requiring an unreasonably large number of people to quarantine.
  • Some contact-tracing apps follow black-box algorithms, which preclude the global community of scientists from refining them or adopting them elsewhere.
  • common red flags
  • Models are produced and presented without appropriate expertise.
  • Epidemiological models that can help predict the burden and pattern of spread of Covid-19 rely on a number of parameters that are, as yet, wildly uncertain.
  • n the absence of reliable virological testing data, we cannot fit models accurately, or know confidently what the future of this epidemic will look like
  • and yet numbers are being presented to governments and the public with the appearance of certainty
  • Read Carefully and Trust Cautiously
  • Transparency: Look for how the data, technology, or recommendations are presented.
  • Thoughtfulness: Look for signs of hubris.
  • Example: Telenor
  • Expertise: Look for the professionals. Examine the credentials of those providing and processing the data.
  • Open Platforms: Look for the collaborators.
  • technology companies like Camber Systems, Cubeiq and Facebook have allowed scientists to examine their data,
  • The Covid-19 Mobility Data Network, of which we are part, comprises a voluntary collaboration of epidemiologists from around the world analyzes aggregated data from technology companies to provide daily insights to city and state officials from California to Dhaka, Bangladesh
  • This pandemic has been studied more intensely in a shorter amount of time than any other human event.
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    "This pandemic has been studied more intensely in a shorter amount of time than any other human event. Our globalized world has rapidly generated and shared a vast amount of information about it. It is inevitable that there will be bad as well as good data in that mix. These massive, decentralized, and crowd-sourced data can reliably be converted to life-saving knowledge if tempered by expertise, transparency, rigor, and collaboration. When making your own decisions, read closely, trust carefully, and when in doubt, look to the experts."
Dennis OConnor

Gapminder Tools - 0 views

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    Hans Rosling - Gap Minder - 2019 Iife Expectancy World Regions
Dennis OConnor

Brain Health In The Time of the Coronavirus - BrainHQ from Posit Science - 1 views

    • Dennis OConnor
       
      I've done 163 days of BrainHQ Training. I have experienced significant improvement in all categories of training: Attention, Brain Speed, Memory, People Skills, Intelligence, Navigation. Basic training schedule is every other day for 30 minutes.
  • If staying at home can contribute to a decline in our physical health—which we can address with an exercise program—what does staying at home and socially isolating do to our cognitive health?
  • while we are staying at home and avoiding social contact, we’re depriving our brains of the cognitive stimulation and new learning that naturally come through our everyday lives and interactions with friends, co-workers, and even random strangers.
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  • brain plasticity is a two-way street. In the same way that the brain can build itself through positive brain plasticity, the brain can “unbuild” itself through negative brain plasticity.
  • our favorite topic at Posit Science: brain plasticity, the science of how the brain rewires itself through learning and experience.
  • get your quarantine cognitive exercise program started:
  • New learning
  • Cognitive engagement
  • BrainHQ
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    I found Posit Science and BrainHQ thanks to a suggestion from Dr. Kurisu. He recommended Norman Doige's books, The Brain That Changes Itself; Personal Triumphs from the Frontiers of Brain Science and The Brain's Way of Healing: Remarkable Discoveries and Recoveries from the Frontiers of Neuroplasticity. One of the case studies is about Dr. Michael Merzenich, a research who was vilified by the medical establishment for investigating neuroplasticity. Great story. Merzenich is a founder of PositScience and BrainHQ.
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