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Dennis OConnor

Antibodies and coronavirus immunity: everything we know. - 0 views

slate.com/...dies-immunity-coronavirus.html

covid testing research

shared by Dennis OConnor on 16 Apr 20 - No Cached
  • Antibodies will probably be key to getting us out of this—in one way or another. By Shannon Palus
  • one promising solution is the idea of antibodies and antibody tests.
  • as with everything about the virus, it’s not yet clear what role antibody tests will be able to play in getting us out of this, and it’s even not completely clear how much getting the coronavirus once prevents you from getting it again
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  • What is an antibody?
  • How do I get the anti-coronavirus antibodies?
  • The most basic (and worst) way to get the antibodies is to get the coronavirus.
  • So once you have the antibodies, you are immune against the virus?
  • We can’t count on immunity right now.
  • Wait, but aren’t there people out there who have gotten the novel coronavirus twice, within a short period of time?
  • So if I’ve been sick with COVID-19 already, should I assume I’m immune, or not?
  • OK. Let’s get to the tests. What’s the deal?
  • The fantasy of antibody tests is that they might be deployed to help us determine who can go back to work and school and normal social gatherings.
  • That sounds very promising!
  • even though the tests can provide a guess at immunity, even a positive result cannot guarantee anything.
  • So what are antibody tests actually good for right now?
  • They are tools to gather more data.
  • This is why the National Institutes of Health is currently recruiting 10,000 volunteers to take antibody tests.
  • There’s one clear way that they could help right now on an individual level: We’ve all been asked to basically assume we have the coronavirus; an antibody test could help clarify our own narratives.
  • If you test positive, you can also apply to donate plasma.
  • Dennis OConnor on 16 Apr 20
     
    Recommended by Dr. Michael Kurisu D.O. 4/15/2020 Good summary. Not scientific or too detailed but good overall big picture view
Dennis OConnor

Coronavirus Antibody Tests: Can You Trust the Results? - The New York Times - 0 views

www.nytimes.com/...oronavirus-antibody-tests.html

covid antibodies testing

shared by Dennis OConnor on 26 Apr 20 - No Cached
  • Of the 14 tests, only three delivered consistently reliable results. Even the best had some flaws.
  • Each test was evaluated with the same set of blood samples: from 80 people known to be infected with the coronavirus, at different points after infection; 108 samples donated before the pandemic; and 52 samples from people who were positive for other viral infections but had tested negative for SARS-CoV-2.
  • these tactics mean nothing if the test results can’t be trusted
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  • The proportion of people in the United States who have been exposed to the coronavirus is likely to be 5 percent or less, Dr. Hensley said. “If your kit has a 3 percent false-positive, how do you interpret that? It’s basically impossible,” he said. “If your kit has 14 percent false positive, it’s useless.”
  • The duo recruited Dr. Jeffrey Whitman and Dr. Caryn Bern, who last year published an analysis of antibody tests for Chagas disease. Other graduate students and postdoctoral fellows volunteered to help perform the evaluations.
  • In all, the investigators analyzed 10 rapid tests that deliver a yes-no signal for antibodies, and two tests using a lab technique known as Elisa that indicate the amount of antibodies present and are generally considered to be more reliable.
  • The Bay Area team finished evaluating 12 tests in record time, less than a month. By comparison, the Chagas project required a team of three people working for more than a year just to compare four tests.
  • Having a study design already in hand helped speed the work, but there was one key difference. Decades of data have shown that Chagas disease elicits lifelong immunity.
  • Already Americans are scrambling to take antibody tests to see if they might escape lockdowns. Public health experts are wondering if those with positive results might be allowed to return to work.
  • Tests made by Sure Biotech and Wondfo Biotech, along with an in-house Elisa test, produced the fewest false positives.
  • A test made by Bioperfectus detected antibodies in 100 percent of the infected samples, but only after three weeks of infection.
  • None of the tests did better than 80 percent until that time period, which was longer than expected, Dr. Hsu said.
  • the tests are less likely to produce false negatives the longer ago the initial infection occurred,
  • There are multiple tests that have specificities greater than 95 percent.
  • Dr. Krammer has developed a two-step Elisa test that he said has 100 percent specificity and delivers a measure of the quantity of IgM and IgG antibodies a person has.
  • Scanwell Health, a Los Angeles-based start-up, has ordered millions of test kits from Innovita, a Chinese manufacturer, and has applied to the Food and Drug Administration to market the tests for at-home use.In the new study, the Innovita test detected antibodies in 83 percent of infected people and yielded a false-positive rate of 4 percent.
  • Scanwell Health, said the study looked at an earlier version of Innovita’s test and not the “newer, improved version” his company had ordered. “It will be interesting to see how it performs,”
  • Dennis OConnor on 26 Apr 20
     
    "A team of scientists worked around the clock to evaluate 14 antibody tests. A few worked as advertised. Most did not."
Dennis OConnor

Finding Antibodies that Neutralize SARS-CoV-2 - NIH Director's Blog - 0 views

directorsblog.nih.gov/...ies-that-neutralize-sars-cov-2

research covid-19 SARS-CoV-2

shared by Dennis OConnor on 09 Jul 20 - No Cached
  • Dennis OConnor on 09 Jul 20
     
    "It's now clear that nearly everyone who recovers from coronavirus disease 2019 (COVID-19) produces antibodies that specifically target SARS-CoV-2, the novel coronavirus that causes the infection. Yet many critical questions remain. A major one is: just how well do those particular antibodies neutralize the virus to fight off the infection and help someone recover from COVID-19? Fortunately, most people get better-but should the typical antibody response take the credit?"
Dennis OConnor

The CDC and States Are Misreporting COVID-19 Test Data - The Atlantic - 0 views

www.theatlantic.com/...611935

testing covid antibodies

shared by Dennis OConnor on 22 May 20 - No Cached
  • A negative test result means something different for each test. If somebody tests negative on a viral test, a doctor can be relatively confident that they are not sick right now; if somebody tests negative on an antibody test, they have probably never been infected with or exposed to the coronavirus. (Or they may have been given a false result—antibody tests are notoriously less accurate on an individual level than viral tests.) The problem is that the CDC is clumping negative results from both tests together in its public reporting.
  • Mixing the two tests makes it much harder to understand the meaning of positive tests, and it clouds important information about the U.S. response to the pandemic, Jha said. “The viral testing is to understand how many people are getting infected, while antibody testing is like looking in the rearview mirror. The two tests are totally different signals,” he told us. By combining the two types of results, the CDC has made them both “uninterpretable,” he said.
  • “Combining a test that is designed to detect current infection with a test that detects infection at some point in the past is just really confusing and muddies the water,” Hanage told us.
  • Dennis OConnor on 22 May 20
     
    "The government's disease-fighting agency is conflating viral and antibody tests, compromising a few crucial metrics that governors depend on to reopen their economies. Pennsylvania, Georgia, Texas, and other states are doing the same."
Dennis OConnor

Everything we know about coronavirus immunity, and plenty we still don't - 0 views

www.statnews.com/...odies-and-plenty-we-still-dont

covid testing antibodies

shared by Dennis OConnor on 20 Apr 20 - No Cached
  • an accurate positive test may be hard to interpret: the virus is so new that researchers cannot say for sure what sort of results will signal immunity or how long that armor will last.
  • policymakers may be making sweeping economic and social decisions — plans to reopen businesses or schools, for example — based on limited data, assumptions, and what’s known about other viruses.
  • most experts do think an initial infection from the coronavirus, called SARS-CoV-2, will grant people immunity to the virus for some amount of time.
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  • With data limited, “sometimes you have to act on a historical basis,” Anthony Fauci,
  • Dennis OConnor on 20 Apr 20
     
    Recommended by Tyler Orion: "People who think they've been exposed to the novel coronavirus are clamoring for antibody tests - blood screens that can detect who has previously been infected and, the hope is, signal who is protected from another case of Covid-19."
Dennis OConnor

Mimi Guarneri MD Covid-19 Antibody Tests, Immune Support - YouTube - 0 views

www.youtube.com/watch

covid research

shared by Dennis OConnor on 17 Apr 20 - No Cached
  • Dennis OConnor on 17 Apr 20
     
    In this video, Dr. Guarneri explains basic antibody concepts and shares some insights from small N research at Pacific Pearl
Dennis OConnor

Covid-19 Antibody Test, Seen as Key to Reopening Country, Does Not Yet Deliver - The Ne... - 0 views

www.nytimes.com/...oronavirus-antibody-tests.html

shared by Dennis OConnor on 20 Apr 20 - No Cached
  • Dennis OConnor on 20 Apr 20
     
    DeAunne Denmark, MD, PhD: "To date, the FDA has granted EUA for only these 4 companies: Cellex, Ortho Clinical Diagnostics, Chembio Diagnostic Systems and the Mount Sinai Laboratory. Really looking forward to the validation and head-to-head comparison data promised here from the FDA, Chan Zuckerberg (supposedly this week?), and others. That should be telling... "
Dennis OConnor

HHS Protect Public Data Hub - Therapeutics Distribution - 0 views

protect-public.hhs.gov/...therapeutics-distribution

covid-19

shared by Dennis OConnor on 16 Jan 21 - No Cached
  • Dennis OConnor on 16 Jan 21
     
    "The national map below displays those locations that have received shipments of monoclonal antibody therapeutics under the U.S. Food and Drug Administration Emergency Use Authorization (EUA) authority, within the past several weeks. "
Dennis OConnor

Mimi Guarneri MD on Covid-19 and Vitamins D and C, Antibody Testing, potential spike on... - 0 views

www.youtube.com/watch

covid testing antibodies

shared by Dennis OConnor on 22 May 20 - No Cached
  • Dennis OConnor on 22 May 20
     
    Published May 20, 2020 - Perspective and advice from Mimi Guarneri. Vitamin C and D, right foods, good sleep, time in the sun, all help strengthen the soil. Her explanation of the "Pearl" metaphor resonates.
Dennis OConnor

Study of Healthcare Workers Shows COVID-19 Immunity Lasts Many Months - NIH Director's ... - 0 views

directorsblog.nih.gov/...-19-immunity-lasts-many-months

covid-19

shared by Dennis OConnor on 08 Dec 20 - No Cached
  • Dennis OConnor on 08 Dec 20
     
    "New findings from a study of thousands of healthcare workers in England show that those who got COVID-19 and produced antibodies against the virus are highly unlikely to become infected again, at least over the several months that the study was conducted. In the rare instances in which someone with acquired immunity for SARS-CoV-2 subsequently tested positive for the virus within a six month period, they never showed any signs of being ill."
Dennis OConnor

A serological assay to detect SARS-CoV-2 seroconversion in humans | medRxiv - 0 views

www.medrxiv.org/...2020.03.17.20037713v1

covid research testing

shared by Dennis OConnor on 20 Mar 20 - No Cached
  • While molecular assays to directly detect the viral genetic material are available for the diagnosis of acute infection, we currently lack serological assays suitable to specifically detect SARS-CoV-2 antibodies.
  • Methods: Here we describe serological enzyme-linked immunosorbent assays (ELISA) that we developed using recombinant antigens derived from the spike protein of SARS-CoV-2.
  • Conclusion: Serological assays are of critical importance to determine seroprevalence in a given population, define previous exposure and identify highly reactive human donors for the generation of convalescent serum as therapeutic.
  • Dennis OConnor on 20 Mar 20
     
    Recommended by DeAunne Denmark, MD, PhD: This study is under peer review. Published via the medRxiv preprint server for health sciences.
Dennis OConnor

COVID-19 Testing Project - Pre-print manuscript - 0 views

covidtestingproject.org

covid antibodies testing preprint

shared by Dennis OConnor on 26 Apr 20 - No Cached
  • April 24, 2020: Read our pre-print manuscript. This is a preliminary report of work that has not been certified by peer review. This should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
  • Dennis OConnor on 26 Apr 20
     
    "We are a multidisciplinary team of researchers and physicians at UCSF, UC Berkeley, Chan Zuckerberg Biohub, and Innovative Genomics Institute."
Dennis OConnor

Rogue antibodies could be driving severe COVID-19 - 0 views

www.nature.com/...d41586-021-00149-1

shared by Dennis OConnor on 24 Jan 21 - No Cached
  • Dennis OConnor on 24 Jan 21
     
    DeAunne Denmark MD, PhD; Very interesting developments. Really hope this will start pointing toward more effective, targeted treatments. "Evidence is growing that self-attacking 'autoantibodies' could be the key to understanding some of the worst cases of SARS-CoV-2 infection."
Dennis OConnor

Why we shouldn't have a self-help movement - Lynne McTaggart - 0 views

lynnemctaggart.com/ldnt-have-a-self-help-movement

community compassion empathy

shared by Dennis OConnor on 12 Nov 19 - No Cached
  • Among the pleasure seekers, the psychologists were amazed to discover high levels of inflammation, considered a marker for degenerative illnesses, and lower levels of gene expression involved in antibody synthesis, the body’s response to outside attack.
  • Those whose lives were not as affluent or stress-free but were purposeful and filled with meaning, on the other hand, had low inflammatory markers and a down regulation of stress-related gene expression, both indicative of rude good health.
  • hoosing a life of meaning over one just chasing pleasure is undeniably better for your health.
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  • “making a connection
  • “a sense of purpose.”
  • The key to a long and healthy life is living a life that concerns itself with a meaning beyond satisfying the needs of number one.
  • The quickest route to rewriting your own life’s script was simply reaching out to someone else.
  • Dennis OConnor on 12 Nov 19
     
    "The unhealthy effects of the good life"
Dennis OConnor

Valneva and Pfizer to take Lyme disease vaccine into Phase 3 trial this year - 0 views

www.biopharma-reporter.com/...e-into-Phase-3-trial-this-year

lyme research

shared by Dennis OConnor on 20 Feb 22 - No Cached
  • Dennis OConnor on 02 Mar 22
     
    VLA15 is currently the only active vaccine program in clinical development against Lyme disease. VLA15 is a multivalent recombinant protein vaccine that targets six serotypes of Borrelia representing the most common pathogenic strains found in the United States and Europe. Valneva has completed recruitment and reported initial results for two Phase 2 clinical trials [5,6] of VLA15 in over 800 healthy adults and in which Valneva observed high levels of antibodies against all six serotypes. Valneva announced a collaboration with Pfizer for late phase development and, if approved, commercialization of VLA15 [7]. As part of its collaboration with Pfizer, Valneva accelerated the pediatric development of VLA15 with an additional Phase 2 clinical trial initiated in March 2021. In July 2021, Pfizer and Valneva announced recruitment completion for VLA15-221 with a total of 625 participants, 5 to 65 years of age [8]. The VLA15 program was granted Fast Track designation by the U.S. Food and Drug Administration (FDA) in July 2017 [9].
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