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Dennis OConnor

About the Center | Center for Microbiome Innovation - 0 views

cmi.ucsd.edu/about-center

ecosystem microbiome american gut UCSD Apollo

shared by Dennis OConnor on 29 May 18 - No Cached
  • Dennis OConnor on 29 May 18
     
    "The UC San Diego Center for Microbiome Innovation leverages the university's strengths in clinical medicine, bioengineering, computer science, the biological and physical sciences, data sciences and more to coordinate and accelerate microbiome research. We also develop methods for manipulating microbiomes for the benefit of human and environmental health."
Dennis OConnor

Brain Health In The Time of the Coronavirus - BrainHQ from Posit Science - 1 views

www.brainhq.com/...in-the-time-of-the-coronavirus

Cognitive

shared by Dennis OConnor on 09 May 20 - No Cached
    • Dennis OConnor
      Dennis OConnor on 09 May 20
       
      I've done 163 days of BrainHQ Training. I have experienced significant improvement in all categories of training: Attention, Brain Speed, Memory, People Skills, Intelligence, Navigation. Basic training schedule is every other day for 30 minutes.
  • If staying at home can contribute to a decline in our physical health—which we can address with an exercise program—what does staying at home and socially isolating do to our cognitive health?
  • while we are staying at home and avoiding social contact, we’re depriving our brains of the cognitive stimulation and new learning that naturally come through our everyday lives and interactions with friends, co-workers, and even random strangers.
  • ...6 more annotations...
  • brain plasticity is a two-way street. In the same way that the brain can build itself through positive brain plasticity, the brain can “unbuild” itself through negative brain plasticity.
  • our favorite topic at Posit Science: brain plasticity, the science of how the brain rewires itself through learning and experience.
  • get your quarantine cognitive exercise program started:
  • New learning
  • Cognitive engagement
  • BrainHQ
  • Dennis OConnor on 09 May 20
     
    I found Posit Science and BrainHQ thanks to a suggestion from Dr. Kurisu. He recommended Norman Doige's books, The Brain That Changes Itself; Personal Triumphs from the Frontiers of Brain Science and The Brain's Way of Healing: Remarkable Discoveries and Recoveries from the Frontiers of Neuroplasticity. One of the case studies is about Dr. Michael Merzenich, a research who was vilified by the medical establishment for investigating neuroplasticity. Great story. Merzenich is a founder of PositScience and BrainHQ.
Dennis OConnor

Coronavirus Will Change the World Permanently. Here's How. - POLITICO - 0 views

www.politico.com/...-society-analysis-covid-135579

future disruption covid

shared by Dennis OConnor on 28 Mar 20 - No Cached
  • Instead of asking, “Is there a reason to do this online?” we’ll be asking, “Is there any good reason to do this in person?”
  • saluting our doctors and nurses, genuflecting and saying, “Thank you for your service,”
  • give them guaranteed health benefits and corporate discounts
  • ...131 more annotations...
  • it will force us to reconsider who we are and what we value, and, in the long run, it could help us rediscover the better version of ourselves.
  • has the potential to break America out of the 50-plus year pattern of escalating political and cultural polarization
  • the “common enemy” scenario, in which people begin to look past their differences when faced with a shared external threat
  • second reason is the “political shock wave” scenario
  • enduring relational patterns often become more susceptible to change after some type of major shock destabilizes them
  • now is the time to begin to promote more constructive patterns in our cultural and political discourse. The time for change is clearly ripening.
  • The COVID-19 crisis
  • has already forced people back to accepting that expertise matters.
  • move them back toward the idea that government is a matter for serious people.
  • the end of our romance with market society and hyper-individualism.
  • We could turn toward authoritarianism
  • reorient our politics and make substantial new investments in public goods—for health, especially—and public services.
  • to allowing partial homeschooling or online learning for K-12 kids has been swept away by necessity.
  • the social order it helps support—will collapse if the government doesn’t guarantee income for the millions of workers who will lose their jobs in a major recession or depression
  • de-militarization of American patriotism and love of community will be one of the benefits to come out of this whole awful mess.
  • But how do an Easter people observe their holiest day if they cannot rejoice together on Easter morning?
  • How do Jews celebrate their deliverance from bondage when Passover Seders must take place on Zoom
  • Can Muslim families celebrate Ramadan if they cannot visit local mosques for Tarawih prayers
  • All faiths have dealt with the challenge of keeping faith alive under the adverse conditions of war or diaspora or persecution—but never all faiths at the same time.
  • Contemplative practices may gain popularity
  • One group of Americans has lived through a transformational epidemic in recent memory: gay men. Of course, HIV/AIDS
  • Plagues drive change.
  • awakened us to the need for the protection of marriage
  • People are finding new ways to connect and support each other in adversity
  • demand major changes in the health-care system
  • COVID-19 will sweep away many of the artificial barriers to moving more of our lives online
  • uptake on genuinely useful online tools has been slowed by powerful legacy players,
  • collaboration with overcautious bureaucrats
  • Medicare allowing billing for telemedicine was a long-overdue change
  • s was revisiting HIPAA to permit more medical providers to use the same tools the rest of us use every day to communicate, such as Skype, Facetime and email.
  • The resistance
  • we will be better able to see how our fates are linked.
  • near-impossible to put that genie back in the bottle in the fall
  • college
  • forcing massive changes in a sector that has been ripe for innovation for a long time.
  • Once companies sort out their remote work dance steps, it will be harder—and more expensive—to deny employees those options.
  • Yo-Yo Ma
  • Perhaps we can use our time with our devices to rethink the kinds of community we can create through them
  • This is a different life on the screen from disappearing into a video game or polishing one’s avatar.
  • breaking open a medium with human generosity and empathy
  • Not only alone together, but together alone.
  • The rise of telemedicine
  • Out of necessity, remote office visits could skyrocket in popularity as traditional-care settings are overwhelmed by the pandemic
  • they’ve been forced to make impossible choices among their families, their health and financial ruin.
  • This crisis should unleash widespread political support for Universal Family Care
  • single public federal fund that we all contribute to, that we all benefit from, that helps us take care of our families while we work, from child care and elder care to support for people with disabilities and paid family leave.
  • potlight on unmet needs of the growing older population
  • The reality of fragile supply chains for active pharmaceutical ingredients coupled with public outrage over patent abuses that limit the availability of new treatments has led to an emerging, bipartisan consensus that the public sector must take far more active and direct responsibility for the development and manufacture of medicines.
  • resilient government approach will replace our failed, 40-year experiment with market-based incentives
  • Science reigns again.
  • Truth and its most popular emissary, science, have been declining in credibility for more than a generation
  • Quickly, however, Americans are being reacquainted with scientific concepts like germ theory and exponential growth
  • Unlike with tobacco use or climate change, science doubters will be able to see the impacts of the coronavirus immediately
  • for the next 35 years, I think we can expect that public respect for expertise in public health and epidemics to be at least partially restored
  • Congress can finally go virtual.
  • We need Congress to continue working through this crisis, but given advice to limit gatherings to 10 people or fewer, meeting on the floor of the House of Representatives is not an especially wise option right now
  • nstead, this is a great time for congresspeople to return to their districts and start the process of virtual legislating—permanently
  • Lawmakers will be closer to the voters they represent
  • sensitive to local perspectives and issues
  • A virtual Congress is harder to lobby
  • Party conformity also might loosen with representatives remembering local loyalties over party ties.
  • Big government makes a comeback.
  • Not only will America need a massive dose of big government
  • we will need big, and wise, government more than ever in its aftermath.
  • The widely accepted idea that government is inherently bad won’t persist after coronavirus.
  • functioning government is crucial for a healthy society
  • most people are desperately hoping
  • a rebirth of the patriotic honor of working for the government.
  • the coronavirus crisis might sow the seeds of a new civic federalism, in which states and localities become centers of justice, solidarity and far-sighted democratic problem-solving.
  • we will see that some communities handled the crisis much better than others.
  • success came in states where government, civic and private-sector leaders joined their strengths together in a spirit of self-sacrifice for the common good.
  • The coronavirus is this century’s most urgent challenge to humanity.
  • a new sense of solidarity, citizens of states
  • The rules we’ve lived by won’t all apply
  • pandemic has revealed a simple truth:
  • many policies that our elected officials have long told us were impossible and impractical were eminently possible and practical all along.
  • student loans and medical debt
  • evictions were avoidable; the homeless could’ve been housed
  • Trump has already put a freeze on interest for federal student loans
  • Governor Andrew Cuomo has paused all medical and student debt owed to New York State
  • Democrats and Republicans are discussing suspending collection on—or outright canceling—student loans as part of a larger economic stimulus package
  • It’s clear that in a crisis, the rules don’t apply
  • an unprecedented opportunity to not just hit the pause button and temporarily ease the pain, but to permanently change the rules so that untold millions of people aren’t so vulnerable to begin with.
  • Revived trust in institutions.
  • oronavirus pandemic, one hopes, will jolt Americans into a realization that the institutions and values Donald Trump has spent his presidency assailing are essential to the functioning of a democracy—and to its ability to grapple effectively with a national crisis.
  • government institutions
  • need to be staffed with experts (not political loyalists),
  • decisions need to be made through a reasoned policy process and predicated on evidence-based science and historical and geopolitical knowledge
  • we need to return to multilateral diplomacy,
  • to the understanding that co-operation with allies—and adversaries, too—is especially necessary when it comes to dealing with global problems like climate change and viral pandemics.
  • t public trust is crucial to governance
  • 1918 flu pandemic
  • the main lesson from that catastrophe is that “those in authority must retain the public’s trust” and “the way to do that is to distort nothing, to put the best face on nothing, to try to manipulate no one.”
  • Expect a political uprising.
  • Occupy Wall Street 2.0, but this time much more massive and angrier.
  • Electronic voting goes mainstream.
  • how to allow for safe voting in the midst of a pandemic, the adoption of more advanced technology
  • To be clear, proven technologies now exist that offer mobile, at-home voting while still generating paper ballots.
  • This system is not an idea; it is a reality that has been used in more than 1,000 elections for nearly a decade by our overseas military and disabled voters.
  • hould be the new normal.
  • Election Day will become Election Month.
  • The change will come through expanded early voting and no-excuse mail-in balloting, effectively turning Election Day into Election Month
  • Once citizens experience the convenience of early voting and/or voting by mail, they won’t want to give it up.
  • . Some states, such as Washington, Oregon and Utah, already let everyone vote at home.
  • Voters already receive registration cards and elections guides by mail. Why not ballots?
  • First, every eligible voter should be mailed a ballot and a self-sealing return envelope with prepaid postage.
  • Elections administrators should receive extra resources to recruit younger poll workers, to ensure their and in-person voters’ health and safety, and to expand capacity to quickly and accurately process what will likely be an unprecedented volume of mail-in votes.
  • In the best-case scenario, the trauma of the pandemic will force society to accept restraints on mass consumer culture as a reasonable price to pay to defend ourselves against future contagions and climate disasters alike.
  • In the years ahead, however, expect to see more support from Democrats, Republicans, academics and diplomats for the notion that government has a much bigger role to play in creating adequate redundancy in supply chains—resilient even to trade shocks from allies. This will be a substantial reorientation from even the very recent past.
  • pressure on corporations to weigh the efficiency and costs/benefits of a globalized supply chain system against the robustness of a domestic-based supply chain.
  • other gap that has grown is between the top fifth and all the rest—and that gap will be exacerbated by this crisis.
  • In this crisis, most will earn steady incomes while having necessities delivered to their front doors.
  • other 80 percent of Americans lack that financial cushion.
  • will struggle
  • A hunger for diversion.
  • After the disastrous 1918-19 Spanish flu and the end of World War I, many Americans sought carefree entertainment, which the introduction of cars and the radio facilitated.
  • The economy quickly rebounded and flourished for about 10 years, until irrational investment tilted the United States and the world into the Great Depression.
  • human beings will respond with the same sense of relief and a search for community, relief from stress and pleasure.
  • Less communal dining—but maybe more cooking
  • many people will learn or relearn how to cook over the next weeks.
  • ikely there will be many fewer sit-down restaurants in Europe and the United States. We will be less communal at least for a while.
  • A revival of parks.
  • Urban parks—in which most major cities have made significant investments over the past decade—are big enough to accommodate both crowds and social distancing.
  • Society might come out of the pandemic valuing these big spaces even more,
  • A change in our understanding of ‘change.’
  • Americans have said goodbye to a society of frivolity and ceaseless activity in a flash
  • Our collective notions of the possible have changed already
  • The tyranny of habit no more.
  • Maybe, as in Camus’ time, it will take the dual specters of autocracy and disease to get us to listen to our common sense, our imaginations, our eccentricities—and not our programming.
  • and environmentally and physiologically devastating behaviors (including our favorites: driving cars, eating meat, burning electricity)
  • echarged commitment to a closer-to-the-bone worldview that recognizes we have a short time on earth
Dennis OConnor

NeuroGym - The Science - 0 views

www.myneurogym.com/the-science

research

shared by Dennis OConnor on 20 Oct 19 - No Cached
  • Dennis OConnor on 20 Oct 19
     
    "Repeatable, Practical, Proven, Peer-Reviewed Science From cradle to the grave, your brain will process more events than there are stars in our universe. As your body's "central processing unit," your brain is in charge of a staggering array of functions, from processing and perceiving stimuli to motor control and memory storage. Habits and beliefs programmed into your mind over a lifetime of responding to experiences are stored in long-term memory, and may cause you to resist new ways of doing things. However, rapid shifts in neural activity can create new associations, habits or beliefs.1 NeuroGym's "Innercising" methods help you to adopt new perceptions and behaviors and solve old problems quickly and efficiently. Moreover, Innercising® applies practical mental training techniques shown through scientific research to improve mental and emotional functioning. 1. Sánchez-Cañizares, J. (2014). The role of consciousness in triggering intellectual habits. Frontiers in human neuroscience, 8."
Dennis OConnor

Registration | Science of Healing Summit 2021 - 0 views

scienceofhealingsummit.com/main

wellness science healing

shared by Dennis OConnor on 13 Mar 21 - No Cached
  • Dennis OConnor on 13 Mar 21
     
    Free Online Event. Hosted by Shamini Jain and Paul MIlls, Science is not only compatible with spirituality; it is a profound source of spirituality. - Carl Sagan
Dennis OConnor

Statistics + Causation + Health | Eric J. Daza, DrPH, MPS - 1 views

www.ericjdaza.com

data statistics health

shared by Dennis OConnor on 15 May 21 - No Cached
  • Dennis OConnor on 15 May 21
     
    "I strive to advance the science of individual well-being by bridging and communicating statistical concepts with precision and empathy. I'm a data science statistician with 18+ years of experience. I build study design and analysis methods for individual-focused digital health using an n-of-1 / single-case causal inference framework."
Dennis OConnor

Welcome | WIFIRE - 0 views

wifire.ucsd.edu

data jessicaBlock

shared by Dennis OConnor on 15 Sep 20 - No Cached
  • Dennis OConnor on 15 Sep 20
     
    "WIFIRE's mission is to turn data into a utility for advancing fire science. This mission comprises: Building workflows to integrate data, software and computing infrastructure Creating systems, services and tools for AI integrated fire science Translating scientific and data advancements into practical use in response and planning"
Dennis OConnor

Frontiers | Digital Twins and the Emerging Science of Self: Implications for Digital He... - 0 views

www.frontiersin.org/...full

self-study

shared by Dennis OConnor on 20 Sep 21 - No Cached
  • Dennis OConnor on 20 Sep 21
     
    "Digital Twins and the Emerging Science of Self: Implications for Digital Health Experience Design and "Small" Data"
Dennis OConnor

Personal Science… by Gary Isaac Wolf in collaboration with Thomas Blomseth Ch... - 0 views

leanpub.com/Personal-Science

quantified tracking self-study

shared by Dennis OConnor on 08 Apr 22 - No Cached
  • Dennis OConnor on 08 Apr 22
     
    "Thank you for considering buying our book, Personal Science: Learning to Observe. The book presents a step-by-step approach to exploring your personal questions with empirical methods. It contains no advice whatsoever on what treatments or medicines or diets or vitamins or exercises are worth trying. Instead, it offers meta-advice; that is, advice on how to know if the things that you try actually work the way you expect, and advice about how to develop reasonable new ideas of things to try."
Dennis OConnor

Test Your Assumptions With UC San Diego Citizen Science Online Tool | KPBS - 0 views

www.kpbs.org/...umptions-ucsd-citizen-science-

citizen-science

shared by Dennis OConnor on 08 Feb 19 - No Cached
  • Dennis OConnor on 08 Feb 19
     
    Click through to hear an 8 minute interview with Austin Durant, citizen experimenter and founder and chief fermentation officer, Fermenters Club and Vineet Pandey, lead designer and developer, Galileo. "Ever wonder if kombucha, the fermented tea drink, is actually good for you? Like many food and drinks touted as healthy, there hasn't been much scientific research to rely on and you'd just have to come to your own conclusions. Now a tool out of UC San Diego is empowering regular citizens to design experiments to test hypotheses and recruit participants, becoming scientists themselves. The tool is called Galileo and encourages participants to test their intuitions by asking questions like, can a vegan diet improve energy levels? Or does drinking coffee every day reduce the quality of sleep?"
Dennis OConnor

Home - Science Gateways Community Institute (SGCI) - 0 views

sciencegateways.org

shared by Dennis OConnor on 23 Aug 19 - No Cached
  • Dennis OConnor on 23 Aug 19
     
    "We provide NSF-funded, online and in-person resources and services. Our goal is to facilitate-at little or no cost-the sharing of experiences, technologies, and practices of those working with science gateways."
Dennis OConnor

Barbarians at the Gate: Consumer-Driven Health Data Commons and the Transformation of C... - 0 views

papers.ssrn.com/...papers.cfm

data sharing collective-creations

shared by Dennis OConnor on 28 Jul 18 - No Cached
  • Dennis OConnor on 28 Jul 18
     
    "Current research and privacy regulations, which were designed for clinical research and for small-data studies of the past, cannot support creation of the vast data resources that 21st-century science needs. These regulations enshrine data-holders (hospitals, insurers, and other entities that store people's data) as the prime movers in assembling large-scale data resources for scientific use and rely on mechanisms - such as de-identification of data and waivers of individual consent - that are unworkable going forward. They shower individuals with unwanted, paternalistic protections - such as barriers to access to their own research results - while denying them a voice in what will be done with their data."
Dennis OConnor

What is biohacking? The new "science" of optimizing your brain and body. - Vox - 0 views

www.vox.com/...ion-genetic-engineering-crispr

shared by Dennis OConnor on 18 Aug 19 - No Cached
  • Dennis OConnor on 18 Aug 19
     
    "Biohacking - also known as DIY biology - is an extremely broad and amorphous term that can cover a huge range of activities, from performing science experiments on yeast or other organisms to tracking your own sleep and diet to changing your own biology by pumping a younger person's blood into your veins in the hope that it'll fight aging. "
Dennis OConnor

World Class Science - BrainHQ from Posit Science - 0 views

www.brainhq.com/world-class-science

training cognition

shared by Dennis OConnor on 22 Apr 19 - No Cached
  • Dennis OConnor on 22 Apr 19
     
    Research background on BrainHQ. Includes section specifically for researchers interested in Brain Training and Neuroplasticity.
Dennis OConnor

Substantial undocumented infection facilitates the rapid dissemination of novel coronav... - 0 views

science.sciencemag.org/...science.abb3221

covid research testing

shared by Dennis OConnor on 21 Mar 20 - No Cached
  • AbstractEstimation of the prevalence and contagiousness of undocumented novel coronavirus (SARS-CoV2) infections is critical for understanding the overall prevalence and pandemic potential of this disease. Here we use observations of reported infection within China, in conjunction with mobility data, a networked dynamic metapopulation model and Bayesian inference, to infer critical epidemiological characteristics associated with SARS-CoV2, including the fraction of undocumented infections and their contagiousness. We estimate 86% of all infections were undocumented (95% CI: [82%–90%]) prior to 23 January 2020 travel restrictions. Per person, the transmission rate of undocumented infections was 55% of documented infections ([46%–62%]), yet, due to their greater numbers, undocumented infections were the infection source for 79% of documented cases. These findings explain the rapid geographic spread of SARS-CoV2 and indicate containment of this virus will be particularly challenging.
  • Dennis OConnor on 21 Mar 20
     
    Recommended by Jessica Block
Dennis OConnor

Eric Heckler - ASU: Agile Science Home - 0 views

www.agilescience.org

hekler

shared by Dennis OConnor on 08 Jan 19 - No Cached
  • Dennis OConnor on 08 Jan 19
     
    "Agile science is: people-centered as it is grounded in the real-world needs of individuals.   success-oriented as we ground all evaluation and optimization on clearly defined criteria of success.   efficiently  rigorous via the classic scientific concept of triangulation. We strive to clarify the most important assumption being made at a given moment and then evaluate it as efficiently and rigorously as possible. We then iterate and test again, often with a complementary but also efficient method for the stage of the process to balance strengths/limitations of the approaches." Eric Hekler, Ph.D. Associate Professor Department of Family Medicine & Public Health Director, Center for Wireless & Population Health Systems
Dennis OConnor

The Moral Determinants of Health | Health Disparities | JAMA | JAMA Network - 0 views

jamanetwork.com/...2767353

health prevention

shared by Dennis OConnor on 25 Aug 20 - No Cached
  • How do humans invest in their own vitality and longevity? The answer seems illogical. In wealthy nations, science points to social causes, but most economic investments are nowhere near those causes. Vast, expensive repair shops (such as medical centers and emergency services) are hard at work, but minimal facilities are available to prevent the damage.
  • Dennis OConnor on 25 Aug 20
     
    by Donald M. Berwick, MD, MPP1 How do humans invest in their own vitality and longevity? The answer seems illogical. In wealthy nations, science points to social causes, but most economic investments are nowhere near those causes. Vast, expensive repair shops (such as medical centers and emergency services) are hard at work, but minimal facilities are available to prevent the damage.
Dennis OConnor

Study: Brain Exercises Provide Breakthrough Treatment for Geriatric Depression - BrainH... - 0 views

www.brainhq.com/...tment-for-geriatric-depression

research brainhq

shared by Dennis OConnor on 01 Jul 20 - No Cached
  • Dennis OConnor on 01 Jul 20
     
    "SAN FRANCISCO - For the first time in a randomized controlled trial, brain exercises were shown effective in addressing depression in treatment-resistant older patients, who had previously used anti-depressive drug therapy without success. The exercises were shown to improve not only mood, but also the often-unaddressed cognitive deficits associated with geriatric depression. The study used neuroplasticity-based exercises from BrainHQ, the brain training app from Posit Science, plus two new exercises designed for the study."
  • Dennis OConnor on 01 Jul 20
     
    While the term 'geriatric depression' tastes like ashes, I was pleased to see this research. I've been working with BrainHQ for some time and I can feel the neuroplastic growth.
Dennis OConnor

A unified genealogy of modern and ancient genomes - 0 views

www.science.org/...science.abi8264

genomics research

shared by Dennis OConnor on 02 Mar 22 - No Cached
  • Dennis OConnor on 02 Mar 22
     
    "Genomics and human ancestral genealogy Hundreds of thousands of modern human genomes and thousands of ancient human genomes have been generated to date. However, different methods and data quality can make comparisons among them difficult. Furthermore, every human genome contains segments from ancestries of varying ages. Wohns et al. applied a tree recording method to ancient and modern human genomes to generate a unified human genealogy (see the Perspective by Rees and Andrés). This method allows for missing and erroneous data and uses ancient genomes to calibrate genomic coalescent times. This permits us to determine how our genomes have changed over time and between populations, informing upon the evolution of our species. -LMZ"
Dennis OConnor

Science - Novoron Bioscience - 0 views

www.novoron.com/science

ecosystem

shared by Dennis OConnor on 21 Jul 18 - No Cached
  • Dennis OConnor on 21 Jul 18
     
    "Novoron's scientific foundation is the discovery of a novel receptor for the components of myelin that inhibit regeneration of the central nervous system (CNS) after injury (1). This pioneering research has led to a novel approach to nerve regeneration that is applicable to a number of CNS disorders and diseases, including spinal cord injury, multiple sclerosis and glaucoma.  Novoron's proprietary technology has been exclusively licensed from the University of California, San Diego (2)."
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