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Dennis OConnor

Knight Lab - 0 views

  • The Knight Lab uses and develops state-of-the-art computational and experimental techniques to ask fundamental questions about the evolution of the composition of biomolecules, genomes, and communities in different ecosystems, including the complex microbial ecosystems of the human body. We subscribe to an open-access scientific model, providing free, open-source software tools and making all protocols and data publicly available in order to increase general interest in and understanding of microbial ecology, and to further public involvement in scientific endeavors more generally.
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    Rob Knight PHD, Embriette Hyde PHD, Sandrine Miller Montgomery PharmD PHD The Knight Lab uses and develops state-of-the-art computational and experimental techniques to ask fundamental questions about the evolution of the composition of biomolecules, genomes, and communities in different ecosystems, including the complex microbial ecosystems of the human body. We subscribe to an open-access scientific model, providing free, open-source software tools and making all protocols and data publicly available in order to increase general interest in and understanding of microbial ecology, and to further public involvement in scientific endeavors more generally.
Dennis OConnor

Mindful Healthcare Summit - A FREE Online Event - 0 views

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    Jon Kabat-Zinn, PHD: Founder of Mindfulness-Based Stress Reduction (MBSR) Susan Bauer-Wu, PhD, RN: Nursing professor, President, Mind & Life Institute Congressman Tim Ryan: Mindfulness advocate, 2020 Presidential candidate Kristin Neff, PhD: Author, Self-Compassion: The Proven Power of Being Kind to Yourself Bobby Mukkamala, MD: Member, AMA Board of Trustees Ron Epstein, MD: Author, Attending: Mindfulness, Medicine and Humanity And many others!
Dennis OConnor

Neural Interaction Lab - Todd P. Coleman | UCSD Bioengineering - 0 views

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    Neural Integration - Todd Coleman PHD, Armen Gharibans PHD
Dennis OConnor

Harnessing wearable device data to improve state-level real-time surveillance of influe... - 0 views

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    "Jennifer M Radin, PhD Nathan E Wineinger, PhD Prof Eric J Topol, MD Steven R Steinhubl, MD"
Dennis OConnor

Leroy Hood, MD, PhD · Institute for Systems Biology - 1 views

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    "Leroy Hood, MD, PhD SVP and Chief Science Officer, Providence St. Joseph Health; Chief Strategy Officer, Co-founder and Professor, ISB"
Dennis OConnor

Lotus | TCM (Traditional Chinese Medicine) Resources for COVID-19 - 0 views

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    Recommended by Erin Raskin John Chen, PhD, Pharm D, OMD, LAc is a very knowledgeable and generous man.
Dennis OConnor

https://www.medscape.com/viewarticle/917058 - 0 views

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    Spend Money on AI or Just Give Doctors More Time? Eric J. Topol, MD; Abraham Verghese, MD; Danielle Ofri, MD, PhD DISCLOSURES September 04, 2019
Dennis OConnor

About Arivale: Our Team - 0 views

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    Dr. K's mentor "Lee Hood, MD, PhD, is a pioneer in the systems approach to biology and medicine. His research has focused on molecular immunology, biotechnology, and genomics. Dr. Hood began his career at Caltech, where he and his colleagues developed the DNA gene sequencer and synthesizer and the protein synthesizer and sequencer, which paved the way for mapping the human genome. A pillar in the biotechnology field, Dr. Hood has played a role in founding more than fourteen biotechnology companies, including Amgen, Applied Biosystems, Darwin, and Integrated Diagnostics."
Dennis OConnor

Don't "Flatten the Curve," stop it! - Joscha Bach - Medium - 1 views

  • What all these diagrams have in common:
  • They have no numbers on the axes.
  • They don’t give you an idea how many cases it takes to overwhelm the medical system, and over how many days the epidemic will play out.
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  • They suggest that currently, the medical system can deal with a large fraction (like maybe 2/3, 1/2 or 1/3) of the cases, but if we implement some mitigation measures, we can get the infections per day down to a level we can deal with.
  • They mean to tell you that we can get away without severe lockdowns as we are currently observing them in China and Italy.
  • nstead, we let the infection burn through the entire population, until we have herd immunity (at 40% to 70%), and just space out the infections over a longer timespan.
  • The Curve Is a Lie
  • suggestions are dangerously wrong, and if implemented, will lead to incredible suffering and hardship.
  • Let’s try to understand this by putting some numbers on the axes.
  • California has only 1.8.
  • The US has about 924,100 hospital beds (2.8 per 1000 people)
  • Germany have 8
  • South Korea has 12
  • Based on Chinese data, we can estimate that about 20% of COVID-19 cases are severe and require hospitalization
  • many severe cases will survive if they can be adequately provided for at home
  • by some estimates can be stretched to about a 100,000, and of which about 30,000 may be available
  • mportant is the number of ICU beds
  • oxygen, IVs and isolation
  • About 6% of all cases need a ventilator
  • if hospitals put all existing ventilators to use, we have 160,000 of them
  • CDC has a strategic stockpile of 8900 ventilators
  • number of ventilators as a proximate limit on the medical resources, it means we can take care of up to 170,000 critically ill patients at the same time.
  • Without containment, the virus becomes endemic
  • Let’s assume that 55% of the US population (the middle ground) get infected between March and December, and we are looking at 180 million people.
  • the point of my argument is not that we are doomed, or that 6% of our population has to die, but that we must understand that containment is unavoidable, and should not be postponed, because later containment is going to be less effective and more expensive, and leads to additional deaths.
  • About 20% will develop a severe case and need medical support to survive.
  • Severe cases tend to take about 3–6 weeks to recover
  • 6% may need intubation and/or ventilation
  • Once a person is on the ventilator, it often takes about 4 weeks for them to get out of intensive care again.
  • The “flattening the curve” idea suggests that if we wash our hands and stay at home while being sick aggressively enough, we won’t have to stop the virus from becoming endemic and infecting 40% to 70% of all people, but we can slow the spread of the infection so much that out medical system can deal with the case load. This is how our normally distributed curve looks like when it contains 10.8 million patients, of which no more than 170,000 are ill at the same time:
  • Dampening the infection rate of COVID-19 to a level that is compatible with our medical system means that we would have to spread the epidemic over more than a decade!
  • confident that we will have found effective treatments until the
  • reducing the infectivity of the new corona virus to a manageable level is simply not going to be possible by mitigation, it will require containment.
  • My back-of-the-envelope calculation is not a proper simulation, or a good model of what’s going on either. Don’t cite it as such!
  • Of the 180 million, 80% will be regarded as “mild” cases.
  • Containment works
  • China has demonstrated to us that containment works
  • lockdown of Wuhan did not lead to starvation or riots
  • made it possible to focus more medical resources on the region that needed it most
  • implemented effective containment measures as soon as the first cases emerged.
  • South Korea was tracking its first 30 cases very well, until patient 31 infected over 1000 others on a church congregation.
  • For some reason, Western countries refused to learn the lesson.
  • The US, UK and Germany are not yet at this point: they try to “flatten the curve” by implementing ineffective or half hearted measures that are only meant to slow down the spread of the disease
  • instead of containing it.
  • some countries will stomp out the virus and others will no
  • few months from now
  • almost all travel from red zones into green zones will come to a hal
  • world will turn into red zones and green zones
  • Flattening the curve is not an option for the United States, for the UK or Germany. Don’t tell your friends to flatten the curve. Let’s start containment and stop the curve.
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    "Flattening the curve is not an option for the United States, for the UK or Germany. Don't tell your friends to flatten the curve. Let's start containment and stop the curve." Strong article with data visualizations from a Phd working out of MIT/Harvard.
Dennis OConnor

Netflix's Unnatural Selection: Is biohacking ethical? Is gene editing? - Vox - 0 views

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    "Is it ethical to edit your child's DNA - or your own? Does the answer depend on whether you're perfectly healthy or have a condition like vision loss or are dying of a degenerative disease? And does it matter whether you've got a PhD or never set foot in a college classroom?"
Dennis OConnor

Doctors on the Frontlines of the Coronavirus Fight - The Atlantic - 0 views

  • Yui had always counted herself lucky to be among a family of doctors. Now the family is facing the greatest challenge of their lives as they wrestle with the dilemma of caring for their patients even though this risks exposing their loved one
  • Will her family survive the crisis intact?
  • Doctors across America are facing similar predicaments, made all the more acute by the government’s failure to protect them—to warn the public, to provide tests, and to supply enough protective equipment.
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  • When it comes to us being doctors, I worry about [family members] Stephanie and Alex and Jennifer and Pam—about their health, and about the eventual burnout due to everything that’s going on,”
  • As a primary-care physician, she’s the first point of contact with the medical system for many patients.
  • Pam recommended a hospital visit to be tested. “It was already too late for me and my family,” Pamela told me—she had been potentially exposed. Her patient got tested on March 12, and is still waiting for results. “My patient’s test was sent from Baltimore to a lab in Utah, then due to a reagent shortage [a substance needed to process the tests] sent from Utah to Arizona, Arizona back to a lab in North Carolina,” she said.
  • This is a mirror of the dysfunction and delays surrounding the country’s testing crisis, a major factor hamstringing the fight against the virus.
  • Meanwhile, she started feeling sick on Tuesday, and took the test herself. Self-quarantined at home, she thinks it’s only a matter of time, if she does have the virus, before she infects her two children—totally isolating from them would be all but impossible.
  • As a health-care provider, if I test positive, it has big implications for my office, my staff, and all the patients,”
  • Emergency-room doctors, he noted, are among those most at risk.
  • Her emergency room has been seeing more and more patients who have symptoms
  • She wears protective equipment but knows that the hospital could run out.
  • It’s not lost on Koo and her family that medical professionals worldwide have been dying fighting the coronavirus.
  • the main dilemma they’re grappling with is not so much getting sick themselves but spreading the virus to their families, their patients, and the public.
  • his might be the greatest fear of doctors across the country—that they’ll move from being part of the solution to part of the problem.
  • should. It weighs heavily on people.”Yui, for her part, told me she’d never let her fears over the virus stop her from doing her job.
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    Dr. Michael Kurisu D.O.: Another article capturing the dialogue that i hear from a lot of my colleagues and others. We have doctors as well In my family : -My sister is Neuro ICU and director of stroke at Tri city hospital in Oceanside -Her husband is ER doc -My little sister is the PhD in sociology. (She specializes in education programs for the incarcerated and has interest on health access for prisons - which is a frightful place during this pandemic)
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    We are in a war against this virus. First responders are the first line of defense. There is a lack of supplies and central leadership. However, there is no shortagage of courage. When you meet a first responder, say, "Thank you for your service."
Dennis OConnor

Covid-19 Antibody Test, Seen as Key to Reopening Country, Does Not Yet Deliver - The Ne... - 0 views

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    DeAunne Denmark, MD, PhD: "To date, the FDA has granted EUA for only these 4 companies: Cellex, Ortho Clinical Diagnostics, Chembio Diagnostic Systems and the Mount Sinai Laboratory. Really looking forward to the validation and head-to-head comparison data promised here from the FDA, Chan Zuckerberg (supposedly this week?), and others. That should be telling... "
Dennis OConnor

Love & Resilience: The Contemplative Care Summit | Lion's Roar Online - 0 views

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    Recommended by DeAunne Denmark, Phd, MD
Dennis OConnor

Sewage-handling robots help predict COVID-19 outbreaks in San Diego | EurekAlert! Scien... - 0 views

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    "From July to November 2020, Karthikeyan and team, led by Rob Knight, PhD, professor and director of the Center for Microbiome Innovation at UC San Diego, sampled sewage water to see if they could detect SARS-CoV-2, the virus that causes COVID-19. They could. But concentrating the wastewater proved to be a bottleneck -- it's a slow and laborious multi-step process."
Dennis OConnor

Predicting 'Long COVID Syndrome' with Help of a Smartphone App - NIH Director's Blog - 0 views

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    Recommended by Tyler Orion, Endorsed by DeAunne Denmark, MD, PhD :This is an example of the high quality and thoughtful study design needed to accurately and meaningfully interpret real-world tracking data. This prediction signal would not have been detected in the larger (inconsistently reporting) group, or in those who hadn't tracked enough before getting sick. Which relates to the importance of creating a baseline health timeline and consistently collecting robust, standardized pre-intervention contextual data. And another illustration re: why I keep circling back to these in all of our n-of-1 discussions :)
Dennis OConnor

Patient Information | Center for Applied Genomics & Precision Medicine - 1 views

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    Recommended by: DeAunne Denmark, MD, PhD "It's important for the public to be aware of what's available to them in the world of genomics and precision medicine. Various resources are available that provide general and disease-specific information about genomics and precision medicine. A list of some resources available to the public is provided below, but additional resources are likely available through your health provider or other groups such as the US National Institutes of Health."
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    The resource index in this article is incredible.
Dennis OConnor

Rogue antibodies could be driving severe COVID-19 - 0 views

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    DeAunne Denmark MD, PhD; Very interesting developments. Really hope this will start pointing toward more effective, targeted treatments. "Evidence is growing that self-attacking 'autoantibodies' could be the key to understanding some of the worst cases of SARS-CoV-2 infection."
Dennis OConnor

The Pandemic's Biggest Mystery Is Our Own Immune System - The Atlantic by Ed Yong - 0 views

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    Recommended by DeAunne Denmark MD Phd: "...the immune system is very complicated. Arguably the most complex part of the human body outside the brain, it's an absurdly intricate network of cells and molecules that protect us from dangerous viruses and other microbes. These components summon, amplify, rile, calm, and transform one another: Picture a thousand Rube Goldberg machines, some of which are aggressively smashing things to pieces. Now imagine that their components are labeled with what looks like a string of highly secure passwords: CD8+, IL-1β, IFN-γ. Immunology confuses even biology professors who aren't immunologists"
Dennis OConnor

One Man's Quest to Change the Way We Die - How B.J. Miller, a doctor and triple amputee... - 0 views

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    Recommended by DeAunne Denmark MD PhD: BJ Miller, MD @ UCSF Palliative Medicine - one of the foremost experts and innovators in the field. "You don't have to spend much time there (Zen Hospice) to realize that the most crucial, and distinctive, piece of the operation is its staff of volunteers. Freed of most medical duties by the nursing staff, the volunteers act almost as existential nurses. They sit with residents and chat, offering their full attention, unencumbered by the turmoil a family member might feel. The volunteers are ordinary people: retired Macy's executives, social workers, bakers, underemployed millennials or kibitzing empty-nesters. Many are practicing Buddhists. Many are not. (Miller isn't.) But Buddhism informs their training. There's an emphasis on accepting suffering, on not getting tripped up by one's own discomfort around it. "You train people not to run away from hard things, not to run away from the suffering of others," Miller explained.
Dennis OConnor

The Human Connection of Palliative Care: Ten Steps for What To Say and Do - Dr. Diane E... - 0 views

  • Dr. Diane E. Meier is Director of the Center to Advance Palliative Care (CAPC), a national organization devoted to increasing the number and quality of palliative care programs in the United States. In this video, Dr. Meier discusses 10 important steps in palliative care from over a decade of research. This video will serve as a valuable training tool and guide for medical professionals and their families. Under her leadership the number of palliative care programs in U.S. hospitals has more than doubled in the last 5 years.
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    Recommended by DeAunne Denmark MD PhD: "The Human Connection of Palliative Care: Ten Steps for What To Say and Do"
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