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Germs are everywhere: in school, at home, at the gym, at the mall, even on your computer! You're constantly exposed to germs. Fortunately for most of us, our immune systems defend us against germs and microorganisms daily to keep us healthy and prevent infection. The following discussion questions and activities will help your students learn all about the immune system.

This interrupted case study examines molecular genetic evidence reported in scientific literature to determine the fate of Louis-Charles, son of Louis XVI and Marie-Antoinette of France. Controversy and rumors surrounding the death of Louis-Charles suggested that either he died as a young boy while being held in captivity by the French revolutionaries or he escaped and was replaced by a substitute who died in his place. One individual claiming to be Louis-Charles was Karl Naundorff. Students begin the case by preparing pedigrees for the descendants of Maria Theresa and Francis I, the Holy Roman Emperor, parents of Marie-Antoinette. The pedigrees can be used to introduce the concepts of alleles identical-by-descent and cytoplasmic inheritance patterns. Students then compare mitochondrial DNA sequences and XY chromosome sequences from hair, bone, heart, and blood samples taken from descendants of Marie Theresa, Karl Naundorff and the heart of the boy who died in captivity to determine if the latter was truly Louis-Charles. An optional PowerPoint presentation with clicker questions is available to help guide the classroom activities.

This case study was inspired by a real-life scenario, and follows the story of Roberto, a migrant farmworker whose health is impacted by the usage of pesticides on a farm.  With the help of a health care provider, Roberto becomes aware of the effects of pesticides on his well-being. Students utilize a database and draw conclusions from data in order to answer the case questions.  The case concludes with an activity that uses the "intimate debate" technique in which students use scientific data as evidence to argue whether or not the pesticide under discussion should be banned from usage.  This case was originally developed for undergraduate anatomy and physiology or toxicology courses. Students are expected to have some background knowledge in nerve structure and function as well as the mechanics of neural transmission before starting the case.

article addresses student question, "Why do cells use uracil, when thymine is already available?"

Paper Cloning activity with worksheet questions

Chinese scientists say they've genetically modified human embryos for the very first time. The team attempted to modify the gene responsible for beta-thalassaemia, a potentially fatal blood disorder, using a gene-editing technique known as CRISPR/Cas9. Gene editing is a recently developed type of genetic engineering in which DNA is inserted, replaced, or removed. Here, experts weigh-in with ethical questions and considerations.

In this lesson, students consider the case of a young doctor hired by a U.S. pharmaceutical company to test a new antibiotic in Nigeria during a meningitis epidemic. Students work through a Decision-Making Framework in small groups, in which they identify the ethical question, determine which facts are known or unknown, consider the values of different stakeholder groups, generate possible solutions, and then make and justify a decision about the case. 

The external environment's effects upon genes can influence disease, and some of these effects can be inherited in humans. Studies investigating how environmental factors impact the genetics of an individual's offspring are difficult to design. However, in certain parts of the world in which social systems are highly centralized, environmental information that might have influenced families can be obtained. For example, Swedish scientists recently conducted investigations examining whether nutrition affected the death rate associated with cardiovascular disease and diabetes and whether these effects were passed from parents to their children and grandchildren (Kaati et al., 2002). These researchers estimated how much access individuals had to food by examining records of annual harvests and food prices in Sweden across three generations of families, starting as far back as the 1890s. These researchers found that if a father did not have enough food available to him during a critical period in his development just before puberty, his sons were less likely to die from cardiovascular disease. Remarkably, death related to diabetes increased for children if food was plentiful during this critical period for the paternal grandfather, but it decreased when excess food was available to the father. These findings suggest that diet can cause changes to genes that are passed down though generations by the males in a family, and that these alterations can affect susceptibility to certain diseases. But what are these changes, and how are they remembered? The answers to questions such as these lie in the concept of epigenetics.

When Jordan is diagnosed with brain cancer (glioblastoma multiform), his college plans are unexpectedly put on hold. This scenario is presented in order to teach students about gene regulation, as the efficacy of the drug Jordan receives for post-surgical treatment is dependent upon the activity level of a gene encoding a protein involved in DNA repair. This "flipped" case study requires students to prepare in advance outside of class by watching several short videos that have been selected to teach the basics of how cancer forms as well as the role of epigenetics in gene silencing. Inside of class, the case is delivered using progressive disclosure format in which students gradually receive additional information to answer a series of directed questions. To determine a treatment plan for Jordan, students analyze data from a research study involving patients treated for his specific type of cancer. The case is designed for advanced high school biology classes as well as lower-level undergraduate general biology courses for non-majors and majors.

Within a year, Stein's team had designed a clinical trial protocol that turned standard research practices around 180 degrees, launching what it now calls the Signature Clinical Trial Program. Instead of a patient traveling to one of several research sites, Novartis would send the investigational drugs to his or her local oncologist's office. Instead of testing hundreds or thousands of genetically unscreened patients, the company would accept only patients who had the genetic markers the drugs were supposed to target. Instead of waiting months, patients could access the treatments in two or three weeks. Instead of running a large-scale trial to investigate one or two questions, clinicians could conduct smaller, rapid proof-of-concept studies to quickly rule out the tumor types that don't respond to a study agent and identify other tumor types that are potentially treatable with the drug and worthy of further study.

Amanda Briody describes two BioInteractive resources focused on Gorongosa National Park in Mozambique. She uses the short film "The Guide: A Biologist in Gorongosa" to introduce students to the park and its scientists. The Gorongosa Interactive Timeline allows her to ask data-based questions on the park's history and ecology, and have students make evidence-based claims.

Have you ever wondered why people look the way they do? Why our hands and feet have five digits instead of six? Why we stand on two legs instead of four? It took 350 million years of evolution to produce the amazing machine we call the human body and in Your Inner Fish, a three-part series based on the best-selling book of the same name, author and evolutionary biologist Dr. Neil Shubin looks into the past to answer these and other questions.

"I Heart Running" is a case study in which students diagnose the cause of exercise-induced tachycardia in an otherwise healthy, 27-year-old female. The patient, Sam, is a long-distance runner and realizes that her exercising heart rate reaches over 200 beats per minute. As the story of Sam's encounters with her physician develops, students are given results from multiple laboratory tests and detailed patient background information.  Students are guided through the material with a series of questions with the ultimate goal of determining the cause of the exercise-induced tachycardia that Sam experiences. The case study is based on actual laboratory results and was designed for students in an upper-level undergraduate Human Physiology course. In this activity students will learn about heart rate, cardiovascular physiology, and oxygen carrying capacity, and factors which influence these concepts, as they try to diagnose Sam.

What is the recipe for life? If you were to build a cell from scratch, what ingredients would you need? And what kind of environment would you need to cook inanimate matter into a living cell? These are the questions that occupy biochemist Jack Szostak, as he imagines the dynamic world where life was born.

Many biology courses are designed to develop student understanding and application of the scientific method, but few seriously examine the various ethical questions associated with scientific research. This interdisciplinary case study presents three experiments and asks not only if they are scientifically valid but whether they were ethically performed.  The experiments examine the psychology of love, a cause of breast cancer, and how the immune system functions in the presence of cancer. Based on their opinions of the validity and ethics of each experiment, students are asked to conclude which of the experiments were actually conducted by scientists and which are fictional. Students should already be familiar with the scientific method, but information on the Georgetown Mantra and Nuremberg Code.is included. The case could be modified for use in non-majors and majors classes.  The format of the case challenges students of any background to use information from both science and ethics to see how the differing approaches of scientist and ethicist can complement and strengthen each other.

If you were limited to choosing only three crops to sustainably farm in an arid, inhospitable environment, what would they be and how would you decide? This interrupted case study places students in the role of a proposed self-sufficient Martian colony that requires an optimized profile of food crops. After students form small groups, they discuss the factors that affect sustainability of a food supply, determine criteria for selection of crops to grow, and rank crops using these criteria. Lists of criteria and of foodstuffs are provided, but the case can easily be transformed into a problem-based learning (PBL) case by having students research and generate their own lists. The case includes questions that walk students through the selection process and require them to explain why they chose their criteria and how those criteria apply to their chosen foods. The case is designed for undergraduate students at the introductory level in courses in astronomy/astrobiology, food science/nutrition, agricultural engineering, or any discipline where sustainability is a key theme.

3:30 video Let's end this age-old question once and for all: Is that cell phone in your pocket giving you cancer?

9:14 video Have you ever wondered how life first got started on Earth? So do scientists! Though the question has not yet been fully answered, a careful study of Chemical Evolution is beginning to shed light on this mystery. In this film you will learn what Chemical Evolution is, how it works, and how it is different from Biological Evolution.

8:38 video Ever wonder why we still haven't cured cancer? Join SciShow as we discuss what's wrong with that question and why it's so hard to find a cure.

2:48 video Ever notice how one side of your nose always seems to be more stuffed than the other? What's up with that? Quick Questions knows!