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Parkinson's is a result of the loss of cells in various parts of the brain, including one portion that produces the neurotransmitter dopamine. Dopamine is essential for being able to move in a coordinated way, so the loss of dopamine causes the tremors often associated with the condition. While the exact cause of Parkinson's is unknown, genetics and environment are contributing factors. Most cases occur in patients with no family history of Parkinson's disease, but there are 13 gene mutations that have been linked to either causing the disease or increasing one's risk of developing it. Certainly not everyone who carries these gene mutations develops Parkinson's, but identifying these genetic indicators is the beginning of developing more precise treatments.

Basketball mitosis review game

Your task is to compare two groups of mice to see how well they have learned the platform location. Two reliable measures of learning in mice are 1) the speed at which they find the platform, and 2) the route which they take to the platform (i.e. do they go straight to the platform or do they get a little lost along the way?).  

DNA folding model

Over 20 high quality virtual biology labs

By observing how the cells in the zebrafish's skin responded to injury, the Duke team learned a lot about the skin regeneration process and were surprised by its complexity. They saw that in the hours following a fin amputation, for example, zebrafish regenerated skin through three different mechanisms: the "recruitment" of spare skin cells from other areas, a temporary doubling in size in some pre-existing cells, and the creation of completely new cells.

Behind every fart (and poop) is an army of gut bacteria undergoing some crazy (and crazy useful) biochemistry. Learn what they have in common with beer brewing, and why we'd want to know about this science anyway...

This directed case study was developed to introduce students to the CRISPR-Cas9 system for genome editing. CRISPR-Cas9 has made numerous headlines in both the scientific and popular press, and thus serves as an excellent model for learning current biotechnology and applying concepts from biology courses. After providing a general overview of CRISPR-Cas9, the majority of the case focuses on the clinical applications of the system as experienced by a carrier for the X-linked recessive allele underlying Duchenne Muscular Dystrophy. The case is structured so that students use a variety of popular and scientific sources (some of which may require a subscription to access-check with your institution), increasing in difficulty as they move through each part of the case. The goals are for students to learn the molecular mechanisms of CRISPR-Cas9, the benefits and limitations of the system, and the clinical applications of the technology. Open-ended questions are included to spark discussion of ethical considerations, societal impacts, and the overall implications of the technology.