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An innovative new breeding simulation helps reveal genetic ratios in offspring. With the heredity level of the ConnectedBio Multi-Level Simulation (MLS), students breed pairs of mice with different fur colors and observe the phenotypic ratios in the resulting offspring. The goal of this activity is to demystify the science behind Punnett Squares and encourage students to explore data and statistical representations in genetics and heredity.

12 min video punnett squares intro

Learn how to set up and solve a genetic problem involving multiple alleles using ABO blood types as an example! The Amoeba Sisters walk you through the different phenotypes/genotypes of ABO blood types and how to solve these problems using a Punnett square.

This PowerPoint-driven, flipped case study begins with a short video about a woman suffering from cystic fibrosis (CF) in the 1970s, a friend of the lead author's, whom she met in college and who died in her twenties. Hooked by this personal story, students then delve into the genetics and biology of cystic fibrosis as they learn about the difference between dominant and recessive genes, make Punnett squares that depict various types of inheritance, distinguish between probability and actual numbers, differentiate types of mutations, and learn about the opportunistic infections that CF patients often succumb to.  Students conclude the case by watching two additional videos on chest compression machines and the contemporary life expectancy of patients with CF.  In addition to the scientific content presented in the case, it is hoped that students will empathize with, and be motivated by, the young people presented in the videos as they struggle with a very real, incurable disease deeply rooted in genetics.

Interactive genetics site.  Straight forward games based on Punnett squares using bunny families.

Learn the steps to completing a dihybrid cross! This video will show how to set up everyone's favorite 16 square Punnett square. This video uses vocabulary that was previously defined in the Amoeba Sisters Monohybrid Crosses video.

Explore inheritance when carried on the X chromosome with the Amoeba Sisters!

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