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CASES Online is a collection of investigative lessons, or "cases," for K-12 and undergraduate science education. Using principles of Problem-Based Learning and Investigative Case-Based Learning (and related student-centered pedagogies), our cases are designed to engage students in exploring the science behind real-world problems. Our cases address a variety of learning objectives across the sciences and mathematics. Although our K-12 cases were designed for use in Georgia and meet our state education standards, we have also included the relevant National Science Education Standards. CASES Online is designed to be used by K-12 and undergraduate science educators. By searching our collection, educators can find cases appropriate to their grade levels, subjects, and topics of interest. In order to download case materials for use in the classroom, educators must first register. While there is no charge to register, download, or use these cases -- we request that all users follow the guidelines outlined under our Terms of Use. Educators are also encouraged to submit cases of their own to our collection. To learn how best to use CASES Online, explore the User Guide; otherwise, begin to transform your classroom by searching for cases.

In this "clicker case," students learn about sex determination, meiosis, and chromosomal "crossing over" through the story of Santhi Soundararajan, an athlete from Kathakkurichi, India, who was stripped of a medal at the 2006 Asian Games after failing to pass a sex test. The case is called a clicker case because it combines the use of student personal response systems (clickers) with case teaching methods and formats. The case itself is a PowerPoint presentation (~2 MB) shown in class that is punctuated by questions students respond to using their clickers. It can be adapted for use without these technologies. Developed for an introductory biology class for both majors and non-majors, the case could also be used in an anatomy and physiology course or an endocrinology course.

In this "clicker case," students learn about sex determination, meiosis, and chromosomal "crossing over" through the story of Santhi Soundararajan, an athlete from Kathakkurichi, India, who was stripped of a medal at the 2006 Asian Games after failing to pass a sex test. The case is called a clicker case because it combines the use of student personal response systems (clickers) with case teaching methods and formats. The case itself is a PowerPoint presentation (~2 MB) shown in class that is punctuated by questions students respond to using their clickers. It can be adapted for use without these technologies. Developed for an introductory biology class for both majors and non-majors, the case could also be used in an anatomy and physiology course or an endocrinology course.

This case study focuses on the relationship between evolution and plasticity using a hands-on, inquiry-based approach. Students view examples from the literature that illustrate the difference between nature and nurture, or the relative contributions of genes and the environment in shaping phenotypes. Using the Trinidadian guppy system as an example, students learn about seminal work in the field in addition to exploring quantitative genetic techniques used to partition phenotypic variance between genes (G) and the environment (E). They use real data from one of the publications cited in the case to graph reaction norms illustrating GxE interactions at the family and population level. The inquiry-based approach means that students are introduced to new concepts in a stepwise fashion, and asked to develop and build their understanding using causal, explanatory evidence. The case concludes with an exercise in which students apply their knowledge to a real conservation problem in Trinidad and Tobago, where guppies are native. This case would be appropriate for an upper level biology, genetics, or evolution course.

This case study is used to teach undergraduate students about hydraulic fracturing (hydrofracking), a controversial method for extracting methane from shale. The controversy arises from claims that chemicals used in the fracking process and the methane itself find their way into drinking water and are also sometimes found at dangerous levels in the air. The case study begins in a college chemistry class where a student inquires about a news item he saw about residents setting their tap water on fire. The instructor uses this as an opportunity for the students to research hydrofracking and natural gas, and she then integrate these topics into their present study of isotopes. The class first examines what isotopes are by using a guided inquiry based activity. The students then learn how mass spectrometry, which uses the principles just learned about isotopes, is employed to determine the source of methane in contaminated wells. This case study is designed for freshman chemistry students and students in environmental studies.

This interrupted case study tells the story of Michael, a Harvard law graduate with a stressful job and a seemingly heavy drinking problem. Students are provided with background information, medical history, and lab results in order to guide them towards determining what is wrong with Michael. This study highlights cirrhosis and the effects of alcohol abuse on the liver. Before beginning the case study, students should have a background in the physiological role of the liver and the breakdown of hemoglobin. Students are asked to use the information provided for them in the case study to gather more information about liver cells and their functions, alcohol, and alcoholic liver damage. Ultimately, using multiple blood tests, the Maddrey's discriminant function (DF) score, and results from a magnetic resonance elastography (MRE), they will diagnose Michael with alcoholic cirrhosis. This case was developed for use in a non-majors physiology course, but could easily be used for a majors class.

To what extent should corn be used for the production of ethanol? Are we better off producing corn for food or producing corn for fuel? This case study uses a technique called "intimate debate" (also known as "constructive controversy") in order to examine this issue. Each student participates in a set of mini-debates for which there is no audience. Students are paired with a teammate; these teams then take turns arguing each side of the issue while seated across from their opponents who do the same. The session concludes with opposing teams reaching consensus. Detailed instructions are included in the case handout to prepare students for the experience before debate day. This case was used successfully in a sophomore/junior level, general education, environmental biology course. It would fit appropriately into any college course that discusses environmental issues related to farming practices, land use, alternative fuels, renewable energy, or sustainability.

The Ethics Primer provides engaging, interactive, and classroom-friendly lesson ideas for integrating ethical issues into a science classroom. It also provides basic background on ethics as a discipline, with straightforward descriptions of major ethical theories. Several decision-making frameworks are included to help students apply reasoned analysis to ethical issues. Although the Primer is designed for secondary school science classrooms, it has been used by teachers in a variety of classes and grade levels. It is particularly suited to social studies and integrated/interdisciplinary classrooms. It has also been used with adults. The Primer is not designed to be used cover to cover. Teachers should review materials and select lessons that fit their needs. The Primer is also intended to be used as a general resource, with a wide variety of topics.

At first glance, the research of Bonnie Bassler and Baldomero "Toto" Olivera might not appear to be medical at all. Dr. Bassler works on marine bacteria that glow in the dark, while Dr. Olivera studies venomous snails that hunt by harpooning fish. Yet their findings show what science has revealed time and again-knowledge that can be used to unlock medical secrets is often hidden in unlikely places. Nature has much to teach us, as long as we know where to look and what to look for. Join us for a four-lecture series as Bonnie and Toto guide us through intriguing slices of the natural world revealing how a deeper understanding of nature and biodiversity informs their research into new medicines.

When I speak with educators about the power of hashtags in social media, I get four questions.   1. How do I figure out which hashtag to use and set it up? 2. How do I know what people are saying? 3. How do I know what hashtag people are using if I want to find conversations about an area of interest? 4. How do I know who is using the hashtag? There's a few great sites to help you answer these questions. They are Tagboard, Hashtagify.me, TOPSY, and Twitter.  Let's take a look and how to use these platforms to most effectively answer these questions. How to figure out and set up a hashtag

This clicker case addresses several important concepts related to evolution. First, it explores artificial selection and selective breeding. Charles Darwin used artificial selection as an example to support his Theory of Evolution by Natural Selection. Belyaev's Fox-Farm experiment is used as an example of a study that used selective breeding as the primary experimental procedure to investigate changes in a lineage. Second, it addresses an interesting observation made by Charles Darwin in The Origin of Species in which he noted how domesticated species also show interesting traits such as drooping ears which seem to be common in domesticated species. The "Farm-Fox Experiment" not only demonstrates how a research team can thoroughly investigate an intriguing question, but also serves as a classic example of elegant experimental design. Designed for use in a large introductory-level biology class, this case study would also be appropriate for smaller classes as well as for upper-level evolution courses.

Students use DNA profiling to determine who robbed a bank. After they learn how the FBI's Combined DNA Index System (CODIS) is used to match crime scene DNA with tissue sample DNA, students use CODIS principles and sample DNA fragments to determine which of three suspects matches evidence obtain at a crime location. They communicate their results as if they were biomedical engineers reporting to a police crime scene investigation.

In this laboratory you will use some basic tools of molecular biology to gain an understanding of some of the principles and techniques of genetic engineering. In the first part of the lab, you will use antibiotic-resistance plasmids to transform Escherichia coli. In the second part, you will use gel electrophoresis to separate fragments of DNA for further analysis.

In this video Paul Andersen explains how to run the student's t-test on a set of data. He starts by explaining conceptually how a t-value can be used to determine the statistical difference between two samples. He then shows you how to use a t-test to test the null hypothesis. He finally gives you a separate data set that can be used to practice running the test.

This case study takes place at a fictional biotechnology company developing herbicides against invasive plant species. The case study focuses on five herbicides with different effects on photosynthesis. Students play the role of lab interns and explore photosynthesis and the herbicide effects by engaging in concept mapping, experimental design, data manipulation, and data analysis. The goal is to use the experimental data to predict the steps in photosynthesis that are inhibited by each herbicide. Students should come away from the case study with a process-based understanding of photosynthesis. This case study is designed for the "flipped" classroom with suggested preparatory videos and associated assessment questions included. Videos can be supplemented with textbook readings or mini-lectures. This activity was developed for a non-majors introductory biology course but it could also be used in any general biology course, including majors' courses. It might also be used to establish foundational knowledge for more advanced discussions of photosynthesis in plant biology (botany) courses.

This case study is centered on a real scenario from 2013 in which the Kickstarter fundraising platform included a fundraising proposal from a group wanting to use synthetic biology to make glowing plants. The proposal raised controversy because the Glowing Plant group offered to give away their genetically-modified glowing plant product to investors.  Kickstarter subsequently changed its policy to prevent use of genetically modified organisms as rewards or incentives to investors. This case study was developed for a college first-year seminar focused on the ethics of synthetic biology, and was introduced during the first week of the semester. The case uses the jigsaw teaching method to introduce students both to the mechanics of synthetic biology and to questions about how we should distribute the benefits and burdens associated with new or emerging technologies. It could be adapted for courses in introductory college biology, genetics or bioethics.

This interrupted case study introduces basic modeling to investigate a decline in an American marten population on an island in Southeast Alaska. Two summer field technicians working on a long-term field ecology project for one of their professors notice that there are fewer marten captures this year. Through discussions with their professor, conversations with a local fur trapper, and based on their own observations, they develop a plan to model the population and the potential causes of the decline to solve the mystery. Students use Excel or other database software along with life tables and introductory population ecology to investigate three potential causes of the marten population decline. This case was developed for use in an environmental science or wildlife management course but could also be used in an advanced science high school course or general ecology course. It would be beneficial for students to have some background in statistics including how to interpret R-squared values, p-values, and 95% confidence intervals.

Germs are everywhere: in school, at home, at the gym, at the mall, even on your computer! You're constantly exposed to germs. Fortunately for most of us, our immune systems defend us against germs and microorganisms daily to keep us healthy and prevent infection. The following discussion questions and activities will help your students learn all about the immune system.

Metacognition refers to awareness of one's own knowledge-what one does and doesn't know-and one's ability to understand, control, and manipulate one's cognitive processes (Meichenbaum, 1985). It includes knowing when and where to use particular strategies for learning and problem solving as well as how and why to use specific strategies. Metacognition is the ability to use prior knowledge to plan a strategy for approaching a learning task, take necessary steps to problem solve, reflect on and evaluate results, and modify one's approach as needed.

This case study is based on the 2014 Ebola epidemic that spread to multiple highly populated countries in West Africa, making it the largest and most devastating outbreak in the history of the virus. The storyline, inspired by a compilation of factual information, unfolds through a fictional narrative wherein students play the role of an infectious disease specialist in training to learn about the techniques used in the detection, diagnosis, and management of Ebola virus outbreaks. The story is presented as an interrupted "clicker case" that combines problem-based case teaching methods with simulated biological laboratory inquiry through the use of Case It, a free molecular biology software, along with the NCBI's online bioinformatics tools and databases. Students work in groups to collaboratively explore various biological and social aspects of this infectious disease outbreak. This case was developed for senior students at the secondary level and can be modified for use in an introductory biology, microbiology, or epidemiology course at the undergraduate level.

It's peak cold and flu season, and mucus is making many of our lives miserable. But despite being a little icky, phlegm gets a bad rap. This germ-fighting goo contains cells and chemical compounds that help us power through a cold. You can also think of mucus as a traffic light for your health - what turns up in our used tissues can be a useful clue about the inner workings of our immune systems.