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Pharmacogenomics holds the promise that drugs might one day be tailored to your genetic makeup. By Mayo Clinic Staff Modern medications save millions of lives a year. Yet any one medication might not work for you, even if it works for other people. Or it might cause severe side effects for you but not for someone else. Your age, lifestyle and health all influence your response to medications. But so do your genes. Scientists are working to match specific gene variations with responses to particular medications.

A century of medical advances in a minute of video. See our time-lines for more detail: http://www.understandinganimalresearch.org.uk/why/timeline/ and http://animalresearch.info/en/medical-advances/timeline/

A selection of articles to further your understanding of the production and function of blood within the human body; the views about blood that predominated for centuries and the medical practices that such views helped to engender; the advancements in the medical use and collection of blood brought on by war, most notably World War II; modern-day techniques for the collection, storage, and use of blood. Some articles are augmented by video clips from RED GOLD: THE EPIC STORY OF BLOOD. (The free RealPlayer plug-in is required to view the clips.)

In this directed case study students follow a nurse practitioner and work with a diagnostics team to determine what is wrong with Tristan, an infant who comes to the clinic with multiple bruises. Students are given background and patient history, and are then given results of various blood tests ordered by the diagnostics team. The exercise emphasizes the physiological process of coagulation and the importance of various clotting factors, especially factor VIII. Students will be introduced to results from several blood tests, including: complete blood count, partial thromboplastin time, prothrombin time, metabolic panel, and factor VIII assay. The patient is ultimately diagnosed with severe hemophilia A and the case then introduces students to this disorder, the genetic determinants, the incidence, and ways to manage the disease. The data in this case are real and the story represents the medical history of an actual patient. Originally developed for pre-nursing students, this activity would also be suitable for majors in physiology or pre-medical students; it could also be used in an introductory genetics or biology course.

This dilemma/decision case study is intended to demonstrate how knowledge of signal transduction pathways can be applied to the pharmaceutical industry and within a medical setting. The case scenario revolves around a physician scientist's analysis of a chronic myelogenous leukemia (CML) patient's resistance to the cancer drug Gleevec® (imatinib). Students explore the molecular targets of drugs that inhibit cell signaling, while considering the best course of treatment for the medical patient. Written for an undergraduate sophomore level cell biology course, the case is also suitable for general biology, genetics, molecular biology, pharmacology, and cancer biology.

An elderly woman living independently with some help from her family is brought to the local emergency room because she is confused and vomiting. While her son suspects a stroke, a quick battery of laboratory tests indicates that her current problems are the result of impaired kidney function, an old-fashioned home remedy for ulcers, and her prescribed blood pressure medication. The combination of patient- and drug-related factors produces an acid-base disorder responsible for her confusion. This disorder further disrupts her kidney function. The case illustrates secretion and reabsorption processes in the kidney tubule which regulate plasma and urinary electrolytes (including calcium) and pH. The role of bicarbonate in maintaining systemic pH is emphasized. Interactions among the renal, respiratory and nervous systems in the regulation of systemic pH are also illustrated. Further, basic principles of pharmacotherapy and issues related to the appropriate use of medications are introduced. The case was developed for use in a physiology or human anatomy and physiology course, but it might be used in undergraduate nursing courses as well (e.g., pharmacology, pathophysiology).

Why is their so much secrecy in animal research? Can't we do without animals in medical research? In this video Dr Simon Festing, our ex-Chief Executive, answers questions about why animals are an essential part of medical work. Download this film here: http://ww

At first glance, the research of Bonnie Bassler and Baldomero "Toto" Olivera might not appear to be medical at all. Dr. Bassler works on marine bacteria that glow in the dark, while Dr. Olivera studies venomous snails that hunt by harpooning fish. Yet their findings show what science has revealed time and again-knowledge that can be used to unlock medical secrets is often hidden in unlikely places. Nature has much to teach us, as long as we know where to look and what to look for. Join us for a four-lecture series as Bonnie and Toto guide us through intriguing slices of the natural world revealing how a deeper understanding of nature and biodiversity informs their research into new medicines.

For the second time in four months, researchers have reported autopsy results that suggest Alzheimer's disease might occasionally be transmitted to people during certain medical treatments-although scientists say that neither set of findings is conclusive. The latest autopsies, described in the Swiss Medical Weekly on January 26, were conducted on the brains of seven people who died of the rare, brain-wasting Creutzfeldt-Jakob disease (CJD). Decades before their deaths, the individuals had all received surgical grafts of dura mater-the membrane that covers the brain and spinal cord. These grafts had been prepared from human cadavers and were contaminated with the prion protein that causes CJD.

Hear from some of the country's leading scientists and medical experts who talk about why animal research is critical for medical progress and the advancement of both human and animal health.

More than 60 years ago, Johns Hopkins researchers took cells from a cancer patient - cells that fueled medical breakthroughs, but were used without her consent. Now, her family has reached an agreement with the National Institutes of Health. Terrell Brown reports.

If you love grapefruit and are on certain medications, think twice! Anthony shows us how it could kill you.

Since 2003, the H5N1 influenza virus, more commonly known as the bird flu, has been responsible for the deaths of millions of chickens and ducks and has infected more than 650 people, leading to a 60 percent mortality rate for the latter. Luckily, this virus has yet to achieve human-to-human transmission, but a small number of mutations could change that, resulting in a pandemic. Now a team of investigators from St. Jude Children's Research Hospital, Stanford University Medical Center, and MacroGenics have developed an antibody which has proven 100 percent protective against the virus in two species of animal models.

Gregory Lanzaro, medical entomologist and professor at University of California Davis (UC Davis) and leader of the research team behind the discovery, says they are calling the hybrid mosquito a "super" mosquito because it can survive exposure to the insecticides used to treat bed nets. He and his team report their findings in the Proceedings of the National Academy of Sciences.

I'd come that afternoon to witness what has become a rarity: the non-forensic medical autopsy. "Autopsy" means to see for oneself, and that is exactly what doctors once did. Fifty years ago we performed autopsies on roughly half of patients who died in hospitals. Today, the number of autopsies has dwindled to less than 10 percent, with next to none in nonacademic hospitals.

The alpha-gal-free pig has one express purpose for now: to develop medical products, like blood thinners, that won't set off adverse reactions.

Hyper-IgM syndrome is an X-linked genetic disorder more commonly affecting males than females. It is caused by the lack of heavy chain class-switching from IgM to other isotypes. Patients with hyper-IgM syndrome are susceptible to a variety of infections as demonstrated in this medical case study. Students are presented patient information, symptoms and a diagnosis that must be interpreted. The case was written for use with the team-based learning (TBL) format involving groups of 4-5 students per group, but it could also be completed as an individual project. The case is targeted to premedical/allied health advanced students and is appropriate for any immunology course at the undergraduate or graduate level in a biomedical science program, or health-related professional courses such as advanced physiology, pathophysiology, microbiology, or histology and cytology.

This PowerPoint-driven case study follows the progress of three undergraduate students as they attempt to model the rapid spread of an influenza outbreak to determine whether their local newspaper's claim that "40% of the campus has the flu" is accurate. The case introduces epidemiological modeling using a base model for a seasonal influenza outbreak written in the NetLogo programmable modeling environment. In class, students develop tests for the various parameters of the model, run simulations, and evaluate the output. The students then explore the impact of influenza control strategies (vaccination, isolation, and antiviral medications), and finish with the question of whether the continuing outbreak on campus could be a pandemic. The case is written at a basic level for a lower-level undergraduate lecture-style class, but can be adapted to upper-level courses as well. The case was piloted in four different microbiology courses. The simulations stimulated active discussion and the content worked well, whether it was used in a pre-nursing microbiology or upper-level immunology class.

In both cases, researchers found that ZIKV-177 reduced levels of Zika virus in pregnant mice and their fetuses, compared with pregnant mice that were not given the antibody.

In this interrupted case study, students shadow an endocrinologist as she tries to determine what is wrong with Angela Barber. Angela is a middle-aged woman presenting with symptoms suggestive of a thyroid issue. Students are given background information, patient history, and results from thyroid-specific blood tests. The exercise emphasizes the hypothalamic-pituitary-thyroid axis and particularly highlights the role of negative feedback. Students will use results from serum thyrotropin and thyroid hormone level tests, as well as patient symptoms, to come up with a diagnosis. In preparation for the diagnosis, students are asked to compare the endocrine profiles of patients with Graves' disease, Hashimoto's disease, iodine deficiency (primary hypothyroidism), and various tumors. The case was developed for college-level biology majors in a physiology course, but also has been used successfully for pre-nursing students in a non-majors anatomy and physiology course. Thus, this activity would be suitable for majors in physiology or pre-medical students, as well as allied health majors.