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Paul Andersen explains the two major portions of the molecular biology lab in AP Biology. He starts by discussing the process of transformation. He explains how you can use the pGLO plasmid to produce glowing E. coli bacteria. He then describes how you can use restriction enzymes and the process of gel electrophoresis to cut and separate DNA.

iKeepSafe is dedicated to the education of families on how to stay safe online. That's why we've teamed up with Google to develop curriculum that educators can use in the classroom to teach what it means to be a responsible digital citizen. The curriculum is designed to be interactive, discussion filled and allow students to learn through hands-on and scenario activities. Each workshop contains a resource booklet for both educators and students that can be downloaded in PDF form, presentations to accompany the lesson and animated videos to help frame the conversation.

Explore the cycling of carbon among carbon reservoirs! Then discover the importance of nitrogen, essential for amino acids and nucleotides, and learn about the nitrogen cycle! Vocabulary discussed includes ammonification and denitrification.

The Amoeba Sisters explain enzymes and how they interact with their substrates. Vocabulary covered includes active site, induced fit, coenzyme, and cofactor. Also the importance of ideal pH and temperatures for enzymes are discussed.

It is easy to miss something that is difficult to see and breast cancer tumour growth may go unnoticed. That is why knowing the early signs of breast cancer is key. For many, the first sign of breast cancer is a lump in the breast. However, breast cancer symptoms can vary widely - from lumps to some less obvious signs such as skin changes. Discovering a symptom of breast cancer does not necessarily mean it is cancer, however, it is absolutely vital to have a discussion with your doctor as soon as possible.

A mini-documentary discussing the remarkable regenerative capabilities of the planarian, and how HHMI researcher Alejandro Sánchez Alvarado uses them to study the biology of stem cells.

Geneticist Jennifer Doudna co-invented a groundbreaking new technology for editing genes, called CRISPR-Cas9. The tool allows scientists to make precise edits to DNA strands, which could lead to treatments for genetic diseases … but could also be used to create so-called "designer babies." Doudna reviews how CRISPR-Cas9 works - and asks the scientific community to pause and discuss the ethics of this new tool.

This interrupted case study, designed for an introductory biology or environmental science course, introduces students to the complexity of ecosystems by examining changes in trophic interactions and abiotic factors in a freshwater ecosystem as a result of human actions. The case narrative describes the recent and undesirable appearance of decomposing algae (Cladophora glomerata) on a public beach in the Laurentian Great Lakes. Students are asked to use the scientific method by creating hypotheses and examining observational data to describe biotic and abiotic components of the Great Lakes ecosystem. The case requires students to differentiate between benthic and pelagic environments (e.g., the influence of depth and phytoplankton density on light availability, and the availability of phosphorus) and the interactions between organisms in both environments. Students also examine shifts in these interactions as a result of the newly introduced zebra and quagga mussels, which have ultimately resulted in the algae's presence on the beach. There are also opportunities to discuss the impact of these ecosystem changes on people who own property and/or visit the beach.

In this case study students are provided with information for piecing together the story of how forest fragmentation and biodiversity loss can affect the risk of Lyme disease transmission to humans. The case introduces the dilution effect, a widely accepted theory-and one of the most important ideas in disease ecology-which suggests that disease risk for humans decreases as the diversity of species in an area increases. It also explains how landscape fragmentation, one of the most common threats to biodiversity, can influence the risk of Lyme disease for humans. Students interpret and discuss various figures to develop a concept map that connects all the individual results of the story. Students gain an appreciation for the complexity of species interactions in an ecosystem, the effects of forest fragmentation on these interactions and the possible consequences for human health. This activity was developed for an undergraduate introduction to environmental sciences course under the topic of biodiversity and conservation, but would also be suitable for interdisciplinary studies interested in examining the connections between conservation and public health.

This case study examines the molecular methods that were used to reverse engineer the 1918 influenza virus strain in order to try and solve the mystery of why it was so deadly. The story starts in the 1950s with the unsuccessful attempts to culture the influenza virus and follows scientists through to the turn of the century when cutting edge molecular tools enabled scientists to finally resurrect the 1918 virus through reverse genetics. The history and methods involved in resurrecting this deadly virus are reviewed in class with a PowerPoint presentation containing clicker questions (answered with a personal response system) and discussion questions (answered in small groups). This "clicker case" is suitable for high school biology and lower division undergraduate biology classes for non-majors. It could also be used in any lower division non-major class focused on human disease and the history of human disease.

Explore some properties of water with the Amoeba Sisters! It's all about those hydrogen bonds. Terms discussed include adhesion, cohesion, surface tension, specific heat - all made possible by those amazing hydrogen bonds.

In this video Paul Andersen explains how the climate on the earth is affected by the amount of solar radiation and the greenhouse affect. The addition of anthropogenic greenhouse gases has led to global warming which is impacting humans on the planet. A discussion of the greenhouse effect and greenhouse gases (including water vapor, carbon dioxide, methane, nitrous oxide, and CFCs) is included. Countries have committed to reduce through both the Kyoto Protocol and the Paris Agreement.

Signaling at the neuromuscular junction (NMJ) is a complex process that is required for many actions that sustain life within humans. Toxins that act upon the NMJ, both natural and synthetic, act in a variety of ways to inhibit this function. This case study examines how a variety of toxins can act to disrupt the normal mechanism of function of the NMJ  by placing a protagonist ("Unlucky Chucky") at an eco-spa in Colombia with his good friend Melody. Unfortunately, during their time at the eco-spa, things don't always turn out well for Chucky. A variety of neuromuscular toxins are discussed including curare (d-tubocurarine), Botox (botulinum toxin A), physostigmine and sarin gas (GB). This case was designed to be used in a variety of classrooms ranging from an undergraduate introduction to biology course in a module focused on neuromuscular functioning, to an introduction to physiology course as an introduction to the NMJ; it could also potentially be used in a nursing course that is examining NMJ physiology.

This case study takes place at a fictional biotechnology company developing herbicides against invasive plant species. The case study focuses on five herbicides with different effects on photosynthesis. Students play the role of lab interns and explore photosynthesis and the herbicide effects by engaging in concept mapping, experimental design, data manipulation, and data analysis. The goal is to use the experimental data to predict the steps in photosynthesis that are inhibited by each herbicide. Students should come away from the case study with a process-based understanding of photosynthesis. This case study is designed for the "flipped" classroom with suggested preparatory videos and associated assessment questions included. Videos can be supplemented with textbook readings or mini-lectures. This activity was developed for a non-majors introductory biology course but it could also be used in any general biology course, including majors' courses. It might also be used to establish foundational knowledge for more advanced discussions of photosynthesis in plant biology (botany) courses.

In this interrupted case study students analyze the complexities surrounding identification and confirmation of cancer clusters. The case challenges students to consider the evidence from two different perspectives; a local family physician representing the community, and a cluster investigation officer who has worked on several cancer cluster investigations. This case was inspired by the discussion about a possible cancer cluster in Clyde, Ohio, where around 20 cases of childhood cancer since 2001 fueled public concern, leading to an investigation by the Ohio department of health in 2006. This case was designed for introductory courses in biology and environmental sciences, taken by both science majors and non-science majors. In addition to introductory college classes, this case could also be used in advanced high school biology classes.

To what extent should corn be used for the production of ethanol? Are we better off producing corn for food or producing corn for fuel? This case study uses a technique called "intimate debate" (also known as "constructive controversy") in order to examine this issue. Each student participates in a set of mini-debates for which there is no audience. Students are paired with a teammate; these teams then take turns arguing each side of the issue while seated across from their opponents who do the same. The session concludes with opposing teams reaching consensus. Detailed instructions are included in the case handout to prepare students for the experience before debate day. This case was used successfully in a sophomore/junior level, general education, environmental biology course. It would fit appropriately into any college course that discusses environmental issues related to farming practices, land use, alternative fuels, renewable energy, or sustainability.

This interrupted case study introduces basic modeling to investigate a decline in an American marten population on an island in Southeast Alaska. Two summer field technicians working on a long-term field ecology project for one of their professors notice that there are fewer marten captures this year. Through discussions with their professor, conversations with a local fur trapper, and based on their own observations, they develop a plan to model the population and the potential causes of the decline to solve the mystery. Students use Excel or other database software along with life tables and introductory population ecology to investigate three potential causes of the marten population decline. This case was developed for use in an environmental science or wildlife management course but could also be used in an advanced science high school course or general ecology course. It would be beneficial for students to have some background in statistics including how to interpret R-squared values, p-values, and 95% confidence intervals.

The threat of antibiotic resistance has become so dire that the United Nations General Assembly is holding a meeting to discuss it this month in New York City. Although WHO has been sounding the alarm on antibiotic resistance for years, this month's high-level U.N. meeting represents only the fourth time in the international body's history that its General Assembly-a global deliberative body that primarily grapples with issues like war and economics-has held a meeting to tackle a health topic.

Germs are everywhere: in school, at home, at the gym, at the mall, even on your computer! You're constantly exposed to germs. Fortunately for most of us, our immune systems defend us against germs and microorganisms daily to keep us healthy and prevent infection. The following discussion questions and activities will help your students learn all about the immune system.

This interrupted case study introduces the topic of bacterial sporulation and cannibalism in Bacillus subtilis. The storyline follows Susan and her lab mates who are presenting research at a lab meeting when Susan falls asleep and dreams they are stranded on a deserted island. She makes connections between their fight for survival in the dream and the survival mechanisms of the bacteria they study in the lab. The benefits of sporulation under conditions of sustained stress are fairly obvious, but Susan's dream is used to examine the idea that sporulation may not always be beneficial and that bacteria would not want to commit to entering such a state in response to temporary stresses. Through the analysis of actual data from the scientific literature, students uncover a mechanism by which B. subtilis delays its commitment to sporulation by killing members of its own species to release nutrients (i.e., cannibalism). Originally developed for a general undergraduate microbiology course when discussing the structure and growth of prokaryotic cells, the case could also be used in an introductory biology course that emphasizes bacteria and data literacy.