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"What is Ambitious Science Teaching? Great teaching can be learned. This web site provides a vision of ambitious science instruction for elementary, middle school and high school classrooms. Ambitious teaching deliberately aims to support students of all backgrounds to deeply understand science ideas, participate in the activities of the discipline, and solve authentic problems. We feature 4 core sets of teaching practices that support these goals. These core sets make up the Ambitious Science Teaching Framework. The framework has been based on classroom research from the past 30 years-research that has asked, "What kinds of talk, tasks, and tools do students need in order to fully engage in meaningful forms of science learning?""

When Jordan is diagnosed with brain cancer (glioblastoma multiform), his college plans are unexpectedly put on hold. This scenario is presented in order to teach students about gene regulation, as the efficacy of the drug Jordan receives for post-surgical treatment is dependent upon the activity level of a gene encoding a protein involved in DNA repair. This "flipped" case study requires students to prepare in advance outside of class by watching several short videos that have been selected to teach the basics of how cancer forms as well as the role of epigenetics in gene silencing. Inside of class, the case is delivered using progressive disclosure format in which students gradually receive additional information to answer a series of directed questions. To determine a treatment plan for Jordan, students analyze data from a research study involving patients treated for his specific type of cancer. The case is designed for advanced high school biology classes as well as lower-level undergraduate general biology courses for non-majors and majors.

This case study centers on an active teaching game that simulates a cholera outbreak among five villages along a river, similar to the Haitian outbreak of 2010. By enacting the behaviors of fictional villagers, students learn how trade, travel, sanitation practices and geographic location contribute to the spread of diarrheal disease. Documenting various contamination events of village water supplies allows students to trace the progression of the disease and illustrates how adequate sanitation facilities provide protection against the bacteria Vibrio cholera. Originally designed for an undergraduate upper-division biology course focusing on the epidemiology of diseases, the simulation is also appropriate for microbiology and public health courses, as well as lower division undergraduate biology courses and high school. Biology or epidemiology components of the case study can be highlighted depending on the emphasis of the course being taught. The game can be completed within a 45- to 60-minute class period. Playing cards are available from the Supplemental Materials tab; detailed instructions are found in the teaching notes.

This case study presents the fictional tale of two neighboring towns that have recently experienced a growth boom and are now suffering the environmental consequences. The case provides an opportunity to explore a wide variety of anthropogenic causes of natural capital degradation. Students are assigned the role of scientists working for the regional Department of Environmental Resources Management, and it is their job to discover the underlying causes for a wide variety of citizen complaints and to suggest reasonable and cost effective solutions. The case may be assigned as a recap activity after teaching a unit on natural capital degradation. The case includes a PowerPoint presentation as well as three lab activities that are included in the teaching notes. The case would be appropriate for high school or lower level undergraduate ecology or environmental science courses.

This "clicker case" gives students an opportunity to apply their understanding of three different types of selection (directional, stabilizing, and disruptive) to a variety of model systems. The case describes each type of selection in detail, presents a paradigm case of each, and then uses clicker questions to test whether students can identify the mode of selection in other systems (answers included in the teaching notes).  Nine different studies are presented so that students gain a broad understanding of selection and how environmental factors can impact species differently. The case concludes with an optional discussion activity (also discussed in the teaching notes) to deepen understanding. Although designed for a high school classroom, it could easily be used in a lower-level college course as an engaging introduction or review of concepts. The case could be used at the beginning of an evolution unit, but it would be helpful if the students were familiar with natural selection before completing the activity.

This case study teaches students about allopatric speciation through an investigation of the benthic and limnetic sticklebacks of Paxton Lake, which are among the youngest species on Earth, diverging from each other after the Pleistocene glaciers melted and the Gulf Islands formed. Researchers at the University of British Columbia have carried out a variety of fascinating studies on these hardy little fish. Results from this research (formatted as data sheets included in the teaching notes) are provided to students who design experiments and then compare actual data to investigate why benthic and limnetic sticklebacks seldom interbreed in Paxton Lake. Developed for a first-year biology course for majors organized around the general theme of evolution and the history of life on Earth, this case study is an updated version of another case in the collection, "Something's Fishy in Paxton Lake" (Sharp, 2001). The current version is especially suited for a flipped classroom in which students prepare for class ahead of time with a reading assignment that also involves the viewing of a video by the case authors that introduces the mechanisms of allopatric speciation.

This index organizes teaching resources by topic-related issue and provides teaching resources (case studies, problems, videos, articles, activities, and other resources) which can be used to to facilitate the teaching of introductory non-majors biology using Problem or Case Studies Based Learning.

In this "clicker case," students learn about sex determination, meiosis, and chromosomal "crossing over" through the story of Santhi Soundararajan, an athlete from Kathakkurichi, India, who was stripped of a medal at the 2006 Asian Games after failing to pass a sex test. The case is called a clicker case because it combines the use of student personal response systems (clickers) with case teaching methods and formats. The case itself is a PowerPoint presentation (~2 MB) shown in class that is punctuated by questions students respond to using their clickers. It can be adapted for use without these technologies. Developed for an introductory biology class for both majors and non-majors, the case could also be used in an anatomy and physiology course or an endocrinology course.

In this "clicker case," students learn about sex determination, meiosis, and chromosomal "crossing over" through the story of Santhi Soundararajan, an athlete from Kathakkurichi, India, who was stripped of a medal at the 2006 Asian Games after failing to pass a sex test. The case is called a clicker case because it combines the use of student personal response systems (clickers) with case teaching methods and formats. The case itself is a PowerPoint presentation (~2 MB) shown in class that is punctuated by questions students respond to using their clickers. It can be adapted for use without these technologies. Developed for an introductory biology class for both majors and non-majors, the case could also be used in an anatomy and physiology course or an endocrinology course.

This web site provides tools and resources that support ambitious science instruction at the middle school and high school levels. Ambitious teaching deliberately aims to get students of all racial, ethnic, and class backgrounds to understand science ideas, participate in the discourses of the discipline, and solve authentic problems. We describe 4 core instructional strategies that support this kind of teaching. These "high-leverage" practices make up the Science Learning Framework (below), and have been selected based on extensive research of how young people learn science, on authentic forms of science activity, and how teachers learn to appropriate new practices.

This case study synthesizes students' knowledge of the central dogma and cell structure by examining a rare health disorder in order to understand protein targeting and its medical consequences. Students first identify the molecular alteration in affected members of a family with renal Fanconi syndrome as reported in the New England Journal of Medicine (2014). Students then use an online bioinformatics tool to analyze the wildtype and mutant proteins and examine their subcellular localization. Finally, students use this information to explain the symptoms of affected family members. The case is delivered with a PowerPoint presentation that includes a selection of brainstorming prompts and "clicker questions." Students complete a worksheet (included in the teaching notes) before class, making the activity suitable for a flipped classroom. A second worksheet (also included in the teaching notes) is completed during class. The case is written for an introductory biology course for majors, but could also be used as a unit capstone in a non-majors human biology course; the case is also scalable to upper division courses in physiology that specifically explore kidney function.

Teaching K-12 Science and Engineering During a Crisis aims to describe what high quality science and engineering education can look like in a time of great uncertainty and to support practitioners as they work toward their goals. This book includes guidance for science and engineering practitioners - with an emphasis on the needs of district science supervisors, curriculum leads, and instructional coaches. Teaching K-12 Science and Engineering During a Crisis will help K-12 science and engineering teachers adapt learning experiences as needed to support students and their families dealing with ongoing changes to instructional and home environments and at the same time provide high quality in those experiences.

This case study is centered on a real scenario from 2013 in which the Kickstarter fundraising platform included a fundraising proposal from a group wanting to use synthetic biology to make glowing plants. The proposal raised controversy because the Glowing Plant group offered to give away their genetically-modified glowing plant product to investors.  Kickstarter subsequently changed its policy to prevent use of genetically modified organisms as rewards or incentives to investors. This case study was developed for a college first-year seminar focused on the ethics of synthetic biology, and was introduced during the first week of the semester. The case uses the jigsaw teaching method to introduce students both to the mechanics of synthetic biology and to questions about how we should distribute the benefits and burdens associated with new or emerging technologies. It could be adapted for courses in introductory college biology, genetics or bioethics.

This case study was developed to teach the topic of human ABO blood type and genetic inheritance in biology courses at the lower undergraduate level or upper high school level. It is suitable for entry level biology, genetics, and physiology courses. The case narrative tells the story of Kevin, a teenager who is puzzled by the fact that neither of his parents can donate blood to him. He and his best friend ask their biology teacher for help, and she explains human ABO blood types at the molecular and genetic level to solve the mystery. The case consists of three sections, which can be used sequentially or separately. After completing the case study, students will understand the molecular basis of ABO blood types and how genes control the phenotype and genotype of an individual. They will also have a better understanding of how human ABO blood type is inherited from generation to generation.

This case study was developed to teach students the importance of understanding the behavior of wildlife, explore the difficulty in making management decisions when the public is invested in a species, and to help students develop critical thinking and public speaking skills. Students learn about the conservation status and behavior of the black rhinoceros by reading a primary literature article and answering a series of questions. They then listen to a Radiolab podcast that explores the moral dilemma of whether it is ethically appropriate to shoot an endangered rhinoceros if the purpose is to raise conservation funds. Students are assigned one of five positions and write essays to prepare for a town hall style debate in which they examine the pros and cons of such a decision. The Radiolab podcast is based on real events, and is also representative of many ethical dilemmas that wildlife managers regularly face. This case study is appropriate for several upper division biology courses.

This case study is based on the 2014 Ebola epidemic that spread to multiple highly populated countries in West Africa, making it the largest and most devastating outbreak in the history of the virus. The storyline, inspired by a compilation of factual information, unfolds through a fictional narrative wherein students play the role of an infectious disease specialist in training to learn about the techniques used in the detection, diagnosis, and management of Ebola virus outbreaks. The story is presented as an interrupted "clicker case" that combines problem-based case teaching methods with simulated biological laboratory inquiry through the use of Case It, a free molecular biology software, along with the NCBI's online bioinformatics tools and databases. Students work in groups to collaboratively explore various biological and social aspects of this infectious disease outbreak. This case was developed for senior students at the secondary level and can be modified for use in an introductory biology, microbiology, or epidemiology course at the undergraduate level.

If you're like me, you hate writing "needs support" and/or "lacks evidence" on students' papers. If you do this activity, you won't have to (as much). Here's how it works.

This case is an exploration of the process of natural selection using white clover (Trifolium repens) as an example. In general, two forms of white clover can be found around the world in various habitats. One type is able to produce cyanide in its leaves, while the other is not. This variation within the clover species, along with the fact that cyanide production is paired with the production of a white stripe on the leaf, is used to teach the process of evolution through natural selection. 

Promotes accurate understanding and comprehensive teaching of evolutionary theory for a wide audience Explores the practical applications of evolutionary principles in daily life and the impact of evolutionary theory on culture and society throughout history Offers teaching tools such as unit and lesson plans and classroom activities, as well as additional online content such as podcasts and powerpoint presentations

When an elementary school teacher calls in sick to work, she finds out that she is not the only one who will be missing school that day.  Children from her fifth grade class have also become ill and parents are calling to report the absences. The concerned principal of the school finds out the fifth grade class had a field trip to one of the local parks the day before. The case shows the areas visited by the class and provides discussion between the principal and a physician that teaches the readers about water quality and EPA standards for bacteria levels in recreational water. The case has an optional lab component that provides the theory for three methods that can be used to conduct microbial water analyses.  Procedures are included for teachers to lead a lab activity to test water to identify which location in the park caused the illness. This case study and accompanying laboratory activity are recommended for an environmental engineering course or a lower level science course.

Japanese knotweed (Fallopia japonica) is an invasive plant that can be very hard to eliminate. This PowerPoint-driven case study briefly describes this plant and asks students to identify possible solutions for its control when a homeowner discovers it growing next to his house. The case was designed for an introductory college course, either a general biology course or a plant biology course, and while it can be used as a regular case, it was actually written to assess the students' ability to solve a problem and write an analysis. If you teach with cases, shouldn't you test with cases as well?